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Term:lysophospholipase activity
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Accession:GO:0004622 term browser browse the term
Definition:Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: 2-lysophosphatidylcholine acylhydrolase activity;   lecithinase B activity;   lecitholipase activity;   lysolecithinase activity;   lysophosphatidase activity;   lysophosphatidylcholine hydrolase activity;   phospholipase B activity
 related_synonym: lysophopholipase L2;   lysophospholipase A1;   phosphatidase B
 alt_id: GO:0045126
 xref: EC:;   MetaCyc:LYSOPHOSPHOLIPASE-RXN;   RHEA:15177;   reactome:R-HSA-1482545 "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C";   reactome:R-HSA-1482571 "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C";   reactome:R-HSA-1482612 "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]";   reactome:R-HSA-1482629 "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C";   reactome:R-HSA-1482685 "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]";   reactome:R-HSA-1482696 "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C";   reactome:R-HSA-6814254 "PNPLA6 hydrolyzes LysoPtdCho";   reactome:R-HSA-6814766 "GDPD1 hydrolyzes LysoPtdCho";   reactome:R-HSA-6814778 "GDPD3 hydrolyzes LysoPtdCho";   reactome:R-HSA-8847912 "PNPLA7 hydrolyzes LysoPtdCho"

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lysophospholipase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd12 abhydrolase domain containing 12, lysophospholipase JBrowse link NW_004936620 451,216 531,353 RGD:9068941
G Abhd12b abhydrolase domain containing 12B JBrowse link NW_004936495 14,728,885 14,753,188 RGD:9068941
G Abhd16a abhydrolase domain containing 16A, phospholipase JBrowse link NW_004936727 1,828,966 1,843,334 RGD:9068941
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B JBrowse link NW_004936722 1,658,287 1,671,848 RGD:9068941
G Aspg asparaginase JBrowse link NW_004936621 1,140,651 1,163,608 RGD:9068941
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 JBrowse link NW_004936470 26,994,549 27,099,758 RGD:9068941
G Gde1 glycerophosphodiester phosphodiesterase 1 JBrowse link NW_004936501 5,177,511 5,193,484 RGD:9068941
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 JBrowse link NW_004936490 4,032,412 4,079,243 RGD:9068941
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 JBrowse link NW_004936501 12,391,204 12,397,877 RGD:9068941
G Lipc lipase C, hepatic type JBrowse link NW_004936471 19,604,083 19,733,721 RGD:9068941
G Lypla1 lysophospholipase 1 JBrowse link NW_004936496 937,918 971,315 RGD:9068941
G Lypla2 lysophospholipase 2 JBrowse link NW_004936474 8,945,247 8,949,756 RGD:9068941
G Lyplal1 lysophospholipase like 1 JBrowse link NW_004936650 2,933,661 2,960,558 RGD:9068941
G Mgll monoglyceride lipase JBrowse link NW_004936798 681,549 721,645 RGD:9068941
G Pla2g15 phospholipase A2 group XV JBrowse link NW_004936475 18,571,599 18,584,977 RGD:9068941
G Pla2g4a phospholipase A2 group IVA JBrowse link NW_004936481 3,559,377 3,689,797 RGD:9068941
G Pla2g4b phospholipase A2 group IVB JBrowse link NW_004936471 5,145,736 5,153,930 RGD:9068941
G Pla2g4c phospholipase A2 group IVC JBrowse link NW_004936664 2,201,583 2,237,796 RGD:9068941
G Pla2g4f phospholipase A2 group IVF JBrowse link NW_004936471 5,439,389 5,454,437 RGD:9068941
G Pla2g6 phospholipase A2 group VI JBrowse link NW_004936492 3,011,752 3,060,962 RGD:9068941
G Plb1 phospholipase B1 JBrowse link NW_004936493 4,112,632 4,210,882 RGD:9068941
G Pnpla6 patatin like phospholipase domain containing 6 JBrowse link NW_004936588 4,608,856 4,632,198 RGD:9068941
G Pnpla7 patatin like phospholipase domain containing 7 JBrowse link NW_004936669 535,104 605,993 RGD:9068941
G Pnpla8 patatin like phospholipase domain containing 8 JBrowse link NW_004936653 1,470,314 1,499,813 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14927
    catalytic activity 5224
      hydrolase activity 2286
        hydrolase activity, acting on ester bonds 705
          carboxylic ester hydrolase activity 127
            lysophospholipase activity 24
Path 2
Term Annotations click to browse term
  molecular_function 14927
    catalytic activity 5224
      hydrolase activity 2286
        hydrolase activity, acting on ester bonds 705
          lipase activity 123
            phospholipase activity 103
              lysophospholipase activity 24
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.