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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase A2 activity
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Accession:GO:0004623 term browser browse the term
Definition:Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: lecithinase A activity;   phosphatidolipase activity;   phosphatidylcholine 2-acylhydrolase activity
 narrow_synonym: cytosolic phospholipase A2 activity;   secreted phospholipase A2 activity
 related_synonym: phosphatidase activity;   phospholipase A
 xref: EC:3.1.1.4;   MetaCyc:PHOSPHOLIPASE-A2-RXN;   RHEA:15801;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"


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phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABHD3 abhydrolase domain containing 3, phospholipase JBrowse link 7 66,331,687 66,383,443 RGD:13508589
G CFI complement factor I JBrowse link 32 29,936,447 29,986,755 RGD:13508589
G JMJD7 jumonji domain containing 7 JBrowse link 30 8,859,308 8,865,805 RGD:13508589
G LOC487399 group IIE secretory phospholipase A2 JBrowse link 2 78,834,820 78,838,058 RGD:13508589
G PLA2G10 phospholipase A2 group X JBrowse link 6 28,573,239 28,591,714 RGD:13508589
G PLA2G12A phospholipase A2 group XIIA JBrowse link 32 29,913,223 29,929,802 RGD:13508589
G PLA2G12B phospholipase A2 group XIIB JBrowse link 4 23,539,909 23,561,211 RGD:13508589
G PLA2G1B phospholipase A2 group IB JBrowse link 26 16,248,417 16,257,163 RGD:13508589
G PLA2G2D phospholipase A2 group IID JBrowse link 2 78,739,826 78,745,839 RGD:13508589
G PLA2G2F phospholipase A2 group IIF JBrowse link 2 78,714,251 78,724,257 RGD:13508589
G PLA2G3 phospholipase A2 group III JBrowse link 26 24,127,074 24,132,508 RGD:13508589
G PLA2G4A phospholipase A2 group IVA JBrowse link 7 19,804,412 19,955,215 RGD:13508589
G PLA2G4B phospholipase A2, group IVB (cytosolic) JBrowse link 30 8,865,941 8,878,687 RGD:13508589
G PLA2G4D phospholipase A2 group IVD JBrowse link 30 9,091,147 9,115,090 RGD:13508589
G PLA2G4E phospholipase A2 group IVE JBrowse link 30 9,018,238 9,077,258 RGD:13508589
G PLA2G4F phospholipase A2 group IVF JBrowse link 30 9,150,325 9,165,610 RGD:13508589
G PLA2G5 phospholipase A2 group V JBrowse link 2 78,762,851 78,781,642 RGD:13508589
G PLAAT1 phospholipase A and acyltransferase 1 JBrowse link 34 24,751,404 24,770,690 RGD:13508589
G PLAAT3 phospholipase A and acyltransferase 3 JBrowse link 18 53,367,441 53,412,165 RGD:13508589
G PLAAT4 phospholipase A and acyltransferase 4 JBrowse link 18 53,418,184 53,424,027 RGD:13508589
G PLAAT5 phospholipase A and acyltransferase 5 JBrowse link 18 53,451,302 53,465,375 RGD:13508589
G PLB1 phospholipase B1 JBrowse link 17 22,420,679 22,558,318 RGD:13508589
G PNPLA3 patatin like phospholipase domain containing 3 JBrowse link 10 21,708,439 21,722,282 RGD:13508589
G PROCA1 protein interacting with cyclin A1 JBrowse link 9 42,897,015 42,904,460 RGD:13508589
calcium-dependent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G JMJD7 jumonji domain containing 7 JBrowse link 30 8,859,308 8,865,805 RGD:13508589
G LOC487399 group IIE secretory phospholipase A2 JBrowse link 2 78,834,820 78,838,058 RGD:13508589
G PLA2G1B phospholipase A2 group IB JBrowse link 26 16,248,417 16,257,163 RGD:13508589
G PLA2G2D phospholipase A2 group IID JBrowse link 2 78,739,826 78,745,839 RGD:13508589
G PLA2G2F phospholipase A2 group IIF JBrowse link 2 78,714,251 78,724,257 RGD:13508589
G PLA2G4A phospholipase A2 group IVA JBrowse link 7 19,804,412 19,955,215 RGD:13508589
G PLA2G4B phospholipase A2, group IVB (cytosolic) JBrowse link 30 8,865,941 8,878,687 RGD:13508589
G PLA2G4D phospholipase A2 group IVD JBrowse link 30 9,091,147 9,115,090 RGD:13508589
G PLA2G4E phospholipase A2 group IVE JBrowse link 30 9,018,238 9,077,258 RGD:13508589
G PLA2G4F phospholipase A2 group IVF JBrowse link 30 9,150,325 9,165,610 RGD:13508589
G PLA2G5 phospholipase A2 group V JBrowse link 2 78,762,851 78,781,642 RGD:13508589
calcium-independent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PLA2G15 phospholipase A2 group XV JBrowse link 5 81,269,914 81,280,700 RGD:13508589
G PNPLA8 patatin like phospholipase domain containing 8 JBrowse link 18 12,134,921 12,181,496 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 12786
    catalytic activity 4905
      hydrolase activity 2090
        hydrolase activity, acting on ester bonds 602
          carboxylic ester hydrolase activity 103
            phospholipase A2 activity 26
              calcium-dependent phospholipase A2 activity 11
              calcium-independent phospholipase A2 activity 2
Path 2
Term Annotations click to browse term
  molecular_function 12786
    catalytic activity 4905
      hydrolase activity 2090
        hydrolase activity, acting on ester bonds 602
          lipase activity 92
            phospholipase activity 74
              phospholipase A2 activity 26
                calcium-dependent phospholipase A2 activity 11
                calcium-independent phospholipase A2 activity 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.