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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase A2 activity
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Accession:GO:0004623 term browser browse the term
Definition:Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: lecithinase A activity;   phosphatidolipase activity;   phosphatidylcholine 2-acylhydrolase activity
 narrow_synonym: cytosolic phospholipase A2 activity;   secreted phospholipase A2 activity
 related_synonym: phosphatidase activity;   phospholipase A
 xref: EC:3.1.1.4;   MetaCyc:PHOSPHOLIPASE-A2-RXN;   RHEA:15801;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"


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phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABHD3 abhydrolase domain containing 3, phospholipase JBrowse link 18 21,650,897 21,704,793 RGD:2290271
G AC100868.1 novel protein RGD:2290271
G AC126283.2 novel protein RGD:2290271
G JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough JBrowse link 15 41,828,085 41,848,148 RGD:2290271
G OC90 otoconin 90 JBrowse link 8 132,024,216 132,059,382 RGD:2290271
G PGAP6 post-glycosylphosphatidylinositol attachment to proteins 6 JBrowse link 16 370,788 381,978 RGD:2290271
G PLA2G10 phospholipase A2 group X JBrowse link 16 14,672,548 14,694,662 RGD:2290271
G PLA2G12A phospholipase A2 group XIIA JBrowse link 4 109,709,989 109,730,070 RGD:2290271
G PLA2G12B phospholipase A2 group XIIB JBrowse link 10 72,934,762 72,955,044 RGD:2290271
G PLA2G1B phospholipase A2 group IB JBrowse link 12 120,322,115 120,327,779 RGD:2290271
G PLA2G2A phospholipase A2 group IIA JBrowse link 1 19,975,431 19,980,434 RGD:2290271
G PLA2G2C phospholipase A2 group IIC JBrowse link 1 20,163,055 20,177,439 RGD:2290271
G PLA2G2D phospholipase A2 group IID JBrowse link 1 20,111,939 20,119,566 RGD:2290271
G PLA2G2E phospholipase A2 group IIE JBrowse link 1 19,920,009 19,923,617 RGD:2290271
G PLA2G2F phospholipase A2 group IIF JBrowse link 1 20,139,323 20,150,386 RGD:2290271
G PLA2G4A phospholipase A2 group IVA JBrowse link 1 186,828,900 186,988,981 RGD:2290271
G PLA2G4B phospholipase A2 group IVB JBrowse link 15 41,838,813 41,848,148 RGD:2290271
G PLA2G4C phospholipase A2 group IVC JBrowse link 19 48,047,843 48,111,383 RGD:2290271
G PLA2G4D phospholipase A2 group IVD JBrowse link 15 42,067,009 42,094,562 RGD:2290271
G PLA2G4E phospholipase A2 group IVE JBrowse link 15 41,981,582 42,050,703 RGD:2290271
G PLA2G4F phospholipase A2 group IVF JBrowse link 15 42,139,034 42,156,636 RGD:2290271
G PLA2G5 phospholipase A2 group V JBrowse link 1 20,028,349 20,091,911 RGD:2290271
G PLA2G6 phospholipase A2 group VI JBrowse link 22 38,111,495 38,181,830 RGD:2290271
G PLAAT1 phospholipase A and acyltransferase 1 JBrowse link 3 193,241,128 193,281,639 RGD:2290271
G PLAAT2 phospholipase A and acyltransferase 2 JBrowse link 11 63,552,759 63,565,072 RGD:2290271
G PLAAT3 phospholipase A and acyltransferase 3 JBrowse link 11 63,574,462 63,616,926 RGD:2290271
G PLAAT4 phospholipase A and acyltransferase 4 JBrowse link 11 63,536,808 63,546,458 RGD:2290271
G PLAAT5 phospholipase A and acyltransferase 5 JBrowse link 11 63,461,404 63,491,203 RGD:2290271
G PLB1 phospholipase B1 JBrowse link 2 28,488,578 28,644,142 RGD:2290271
G PNPLA3 patatin like phospholipase domain containing 3 JBrowse link 22 43,923,805 43,947,582 RGD:2290271
G PROCA1 protein interacting with cyclin A1 JBrowse link 17 28,703,197 28,712,065 RGD:2290271
calcium-dependent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC100868.1 novel protein RGD:2290271
G JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough JBrowse link 15 41,828,085 41,848,148 RGD:2290271
G OC90 otoconin 90 JBrowse link 8 132,024,216 132,059,382 RGD:2290271
G PLA2G12A phospholipase A2 group XIIA JBrowse link 4 109,709,989 109,730,070 RGD:2290271
G PLA2G1B phospholipase A2 group IB JBrowse link 12 120,322,115 120,327,779 RGD:2290271
G PLA2G2A phospholipase A2 group IIA JBrowse link 1 19,975,431 19,980,434 RGD:2290271
G PLA2G2D phospholipase A2 group IID JBrowse link 1 20,111,939 20,119,566 RGD:2290271
G PLA2G2E phospholipase A2 group IIE JBrowse link 1 19,920,009 19,923,617 RGD:2290271
G PLA2G2F phospholipase A2 group IIF JBrowse link 1 20,139,323 20,150,386 RGD:2290271
G PLA2G3 phospholipase A2 group III JBrowse link 22 31,134,807 31,140,508 RGD:2290271
G PLA2G4A phospholipase A2 group IVA JBrowse link 1 186,828,900 186,988,981 RGD:2290271
G PLA2G4B phospholipase A2 group IVB JBrowse link 15 41,838,813 41,848,148 RGD:2290271
G PLA2G4C phospholipase A2 group IVC JBrowse link 19 48,047,843 48,111,383 RGD:2290271
G PLA2G4D phospholipase A2 group IVD JBrowse link 15 42,067,009 42,094,562 RGD:2290271
G PLA2G4E phospholipase A2 group IVE JBrowse link 15 41,981,582 42,050,703 RGD:2290271
G PLA2G4F phospholipase A2 group IVF JBrowse link 15 42,139,034 42,156,636 RGD:2290271
G PLA2G5 phospholipase A2 group V JBrowse link 1 20,028,349 20,091,911 RGD:2290271
calcium-independent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PLA2G15 phospholipase A2 group XV JBrowse link 16 68,245,371 68,261,062 RGD:2290271
G PLA2G4C phospholipase A2 group IVC JBrowse link 19 48,047,843 48,111,383 RGD:2290271
G PLA2G6 phospholipase A2 group VI JBrowse link 22 38,111,495 38,181,830 RGD:2290271
G PLA2G7 phospholipase A2 group VII JBrowse link 6 46,700,558 46,735,836 RGD:2290271
G PNPLA8 patatin like phospholipase domain containing 8 JBrowse link 7 108,470,417 108,528,178 RGD:2290271
G PRDX6 peroxiredoxin 6 JBrowse link 1 173,477,335 173,488,815 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17874
    catalytic activity 5933
      hydrolase activity 2599
        hydrolase activity, acting on ester bonds 775
          carboxylic ester hydrolase activity 142
            phospholipase A2 activity 36
              calcium-dependent phospholipase A2 activity 17
              calcium-independent phospholipase A2 activity 6
Path 2
Term Annotations click to browse term
  molecular_function 17874
    catalytic activity 5933
      hydrolase activity 2599
        hydrolase activity, acting on ester bonds 775
          lipase activity 132
            phospholipase activity 109
              phospholipase A2 activity 36
                calcium-dependent phospholipase A2 activity 17
                calcium-independent phospholipase A2 activity 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.