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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase A2 activity
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Accession:GO:0004623 term browser browse the term
Definition:Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: lecithinase A activity;   phosphatidolipase activity;   phosphatidylcholine 2-acylhydrolase activity
 narrow_synonym: cytosolic phospholipase A2 activity;   secreted phospholipase A2 activity
 related_synonym: phosphatidase activity;   phospholipase A
 xref: EC:3.1.1.4;   MetaCyc:PHOSPHOLIPASE-A2-RXN;   RHEA:15801;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"


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phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd3 abhydrolase domain containing 3 JBrowse link 18 10,644,411 10,706,783 RGD:2290270
G Gm28042 predicted gene, 28042 JBrowse link 2 120,027,483 120,043,033 RGD:2290270
G Lcat lecithin cholesterol acyltransferase JBrowse link 8 105,939,551 105,943,402 RGD:2290270
G Oc90 otoconin 90 JBrowse link 15 65,876,050 65,912,411 RGD:2290270
G Pla2g10 phospholipase A2, group X JBrowse link 16 13,715,057 13,731,094 RGD:2290270
G Pla2g12a phospholipase A2, group XIIA JBrowse link 3 129,878,606 129,895,825 RGD:2290270
G Pla2g12b phospholipase A2, group XIIB JBrowse link 10 59,403,420 59,421,976 RGD:2290270
G Pla2g1b phospholipase A2, group IB, pancreas JBrowse link 5 115,466,142 115,474,722 RGD:2290270
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) JBrowse link 4 138,831,857 138,835,189 RGD:2290270
G Pla2g2c phospholipase A2, group IIC JBrowse link 4 138,725,325 138,744,575 RGD:2290270
G Pla2g2d phospholipase A2, group IID JBrowse link 4 138,775,735 138,782,052 RGD:2290270
G Pla2g2e phospholipase A2, group IIE JBrowse link 4 138,877,911 138,882,817 RGD:2290270
G Pla2g2f phospholipase A2, group IIF JBrowse link 4 138,750,533 138,757,598 RGD:2290270
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) JBrowse link 1 149,829,618 149,961,290 RGD:2290270
G Pla2g4b phospholipase A2, group IVB (cytosolic) JBrowse link 2 120,033,433 120,043,033 RGD:2290270
G Pla2g4c phospholipase A2, group IVC (cytosolic, calcium-independent) JBrowse link 7 13,311,507 13,360,674 RGD:2290270
G Pla2g4d phospholipase A2, group IVD JBrowse link 2 120,265,866 120,289,069 RGD:2290270
G Pla2g4e phospholipase A2, group IVE JBrowse link 2 120,166,412 120,245,630 RGD:2290270
G Pla2g4f phospholipase A2, group IVF JBrowse link 2 120,299,952 120,314,165 RGD:2290270
G Pla2g5 phospholipase A2, group V JBrowse link 4 138,799,247 138,863,562 RGD:2290270
G Pla2g6 phospholipase A2, group VI JBrowse link 15 79,286,228 79,328,385 RGD:2290270
G Plaat1 phospholipase A and acyltransferase 1 JBrowse link 16 29,209,133 29,230,531 RGD:2290270
G Plaat3 phospholipase A and acyltransferase 3 JBrowse link 19 7,557,459 7,588,545 RGD:2290270
G Plaat5 phospholipase A and acyltransferase 5 JBrowse link 19 7,612,537 7,641,040 RGD:2290270
G Plb1 phospholipase B1 JBrowse link 5 32,232,691 32,364,356 RGD:2290270
G Pnpla3 patatin-like phospholipase domain containing 3 JBrowse link 15 84,167,776 84,189,521 RGD:2290270
G Prdx6 peroxiredoxin 6 JBrowse link 1 161,240,112 161,251,210 RGD:2290270
G Tmem8 transmembrane protein 8 JBrowse link 17 26,112,752 26,123,254 RGD:2290270
calcium-dependent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gm28042 predicted gene, 28042 JBrowse link 2 120,027,483 120,043,033 RGD:2290270
G Oc90 otoconin 90 JBrowse link 15 65,876,050 65,912,411 RGD:2290270
G Pla2g1b phospholipase A2, group IB, pancreas JBrowse link 5 115,466,142 115,474,722 RGD:2290270
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) JBrowse link 4 138,831,857 138,835,189 RGD:2290270
G Pla2g2c phospholipase A2, group IIC JBrowse link 4 138,725,325 138,744,575 RGD:2290270
G Pla2g2d phospholipase A2, group IID JBrowse link 4 138,775,735 138,782,052 RGD:2290270
G Pla2g2e phospholipase A2, group IIE JBrowse link 4 138,877,911 138,882,817 RGD:2290270
G Pla2g2f phospholipase A2, group IIF JBrowse link 4 138,750,533 138,757,598 RGD:2290270
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) JBrowse link 1 149,829,618 149,961,290 RGD:2290270
G Pla2g4b phospholipase A2, group IVB (cytosolic) JBrowse link 2 120,033,433 120,043,033 RGD:2290270
G Pla2g4c phospholipase A2, group IVC (cytosolic, calcium-independent) JBrowse link 7 13,311,507 13,360,674 RGD:2290270
G Pla2g4d phospholipase A2, group IVD JBrowse link 2 120,265,866 120,289,069 RGD:2290270
G Pla2g4e phospholipase A2, group IVE JBrowse link 2 120,166,412 120,245,630 RGD:2290270
G Pla2g4f phospholipase A2, group IVF JBrowse link 2 120,299,952 120,314,165 RGD:2290270
G Pla2g5 phospholipase A2, group V JBrowse link 4 138,799,247 138,863,562 RGD:2290270
calcium-independent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pla2g15 phospholipase A2, group XV JBrowse link 8 106,150,354 106,164,718 RGD:2290270
G Pla2g4c phospholipase A2, group IVC (cytosolic, calcium-independent) JBrowse link 7 13,311,507 13,360,674 RGD:2290270
G Pla2g6 phospholipase A2, group VI JBrowse link 15 79,286,228 79,328,385 RGD:2290270
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) JBrowse link 17 43,567,994 43,612,202 RGD:2290270
G Pnpla8 patatin-like phospholipase domain containing 8 JBrowse link 12 44,269,132 44,315,936 RGD:2290270
G Prdx6 peroxiredoxin 6 JBrowse link 1 161,240,112 161,251,210 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 22441
    catalytic activity 5706
      hydrolase activity 2469
        hydrolase activity, acting on ester bonds 752
          carboxylic ester hydrolase activity 161
            phospholipase A2 activity 31
              calcium-dependent phospholipase A2 activity 15
              calcium-independent phospholipase A2 activity 6
Path 2
Term Annotations click to browse term
  molecular_function 22441
    catalytic activity 5706
      hydrolase activity 2469
        hydrolase activity, acting on ester bonds 752
          lipase activity 121
            phospholipase activity 88
              phospholipase A2 activity 31
                calcium-dependent phospholipase A2 activity 15
                calcium-independent phospholipase A2 activity 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.