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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase A2 activity
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Accession:GO:0004623 term browser browse the term
Definition:Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: lecithinase A activity;   phosphatidolipase activity;   phosphatidylcholine 2-acylhydrolase activity
 narrow_synonym: cytosolic phospholipase A2 activity;   secreted phospholipase A2 activity
 related_synonym: phosphatidase activity;   phospholipase A
 xref: EC:3.1.1.4;   MetaCyc:PHOSPHOLIPASE-A2-RXN;   RHEA:15801;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"


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phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABHD3 abhydrolase domain containing 3, phospholipase JBrowse link 6 106,851,625 106,917,720 RGD:14298760
G LOC110259864 group 10 secretory phospholipase A2-like JBrowse link 3 7,623,326 7,641,061 RGD:14298760
G OC90 otoconin 90 JBrowse link 4 9,028,483 9,054,503 RGD:14298760
G PLA2G12A phospholipase A2 group XIIA JBrowse link 8 112,483,322 112,512,520 RGD:14298760
G PLA2G12B phospholipase A2 group XIIB JBrowse link 14 75,754,525 75,778,933 RGD:14298760
G PLA2G1B phospholipase A2 group IB JBrowse link 14 40,314,520 40,322,315 RGD:14298760
G PLA2G2A phospholipase A2 group IIA JBrowse link 6 78,327,728 78,339,546 RGD:14298760
G PLA2G2C phospholipase A2 group IIC JBrowse link 6 78,433,168 78,446,562 RGD:14298760
G PLA2G2D phospholipase A2 group IID JBrowse link 6 78,391,063 78,397,394 RGD:14298760
G PLA2G2E phospholipase A2 group IIE JBrowse link 6 78,278,080 78,282,253 RGD:14298760
G PLA2G2F phospholipase A2 group IIF JBrowse link 6 78,413,459 78,423,311 RGD:14298760
G PLA2G3 phospholipase A2 group III JBrowse link 14 47,923,005 47,928,762 RGD:14298760
G PLA2G4A phospholipase A2 group IVA JBrowse link 9 127,853,581 128,164,825 RGD:14298760
G PLA2G4B phospholipase A2 group IVB JBrowse link 1 129,514,801 129,524,365 RGD:14298760
G PLA2G4D phospholipase A2 group IVD JBrowse link 1 129,251,495 129,270,952 RGD:14298760
G PLA2G4E phospholipase A2 group IVE JBrowse link 1 129,288,727 129,364,034 RGD:14298760
G PLA2G4F phospholipase A2 group IVF JBrowse link 1 129,200,568 129,218,417 RGD:14298760
G PLA2G5 phospholipase A2 group V JBrowse link 6 78,365,697 78,376,383 RGD:14298760
G PLAAT1 phospholipase A and acyltransferase 1 JBrowse link 13 130,282,114 130,303,359 RGD:14298760
G PLAAT5 phospholipase A and acyltransferase 5 JBrowse link 2 8,475,107 8,499,181 RGD:14298760
G PNPLA3 patatin like phospholipase domain containing 3 JBrowse link 5 5,075,608 5,092,599 RGD:14298760
G PROCA1 protein interacting with cyclin A1 JBrowse link 12 44,942,146 44,950,899 RGD:14298760
calcium-dependent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G OC90 otoconin 90 JBrowse link 4 9,028,483 9,054,503 RGD:14298760
G PLA2G2D phospholipase A2 group IID JBrowse link 6 78,391,063 78,397,394 RGD:14298760
G PLA2G2E phospholipase A2 group IIE JBrowse link 6 78,278,080 78,282,253 RGD:14298760
G PLA2G2F phospholipase A2 group IIF JBrowse link 6 78,413,459 78,423,311 RGD:14298760
G PLA2G4B phospholipase A2 group IVB JBrowse link 1 129,514,801 129,524,365 RGD:14298760
G PLA2G4D phospholipase A2 group IVD JBrowse link 1 129,251,495 129,270,952 RGD:14298760
G PLA2G4E phospholipase A2 group IVE JBrowse link 1 129,288,727 129,364,034 RGD:14298760
G PLA2G4F phospholipase A2 group IVF JBrowse link 1 129,200,568 129,218,417 RGD:14298760
G PLA2G5 phospholipase A2 group V JBrowse link 6 78,365,697 78,376,383 RGD:14298760
calcium-independent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PLA2G7 phospholipase A2 group VII JBrowse link 7 41,488,152 41,531,383 RGD:14298760
G PNPLA8 patatin like phospholipase domain containing 8 JBrowse link 9 108,271,343 108,320,574 RGD:14298760
G PRDX6 peroxiredoxin 6 JBrowse link 9 115,857,629 115,868,898 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 13492
    catalytic activity 5060
      hydrolase activity 2156
        hydrolase activity, acting on ester bonds 632
          carboxylic ester hydrolase activity 108
            phospholipase A2 activity 25
              calcium-dependent phospholipase A2 activity 9
              calcium-independent phospholipase A2 activity 3
Path 2
Term Annotations click to browse term
  molecular_function 13492
    catalytic activity 5060
      hydrolase activity 2156
        hydrolase activity, acting on ester bonds 632
          lipase activity 100
            phospholipase activity 77
              phospholipase A2 activity 25
                calcium-dependent phospholipase A2 activity 9
                calcium-independent phospholipase A2 activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.