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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase A2 activity
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Accession:GO:0004623 term browser browse the term
Definition:Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: lecithinase A activity;   phosphatidolipase activity;   phosphatidylcholine 2-acylhydrolase activity
 narrow_synonym: cytosolic phospholipase A2 activity;   secreted phospholipase A2 activity
 related_synonym: phosphatidase activity;   phospholipase A
 xref: EC:3.1.1.4;   MetaCyc:PHOSPHOLIPASE-A2-RXN;   RHEA:15801;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"


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phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd3 abhydrolase domain containing 3, phospholipase JBrowse link 18 1,892,413 1,946,840 RGD:1624291
RGD:13792537
G Lcat lecithin cholesterol acyltransferase JBrowse link 19 37,913,333 37,916,799 RGD:729077
G LOC102546467 HERV-H LTR-associating protein 1-like JBrowse link 7 106,442,364 106,485,324 RGD:13792537
G Oc90 otoconin 90 JBrowse link 7 106,615,859 106,697,089 RGD:13792537
G Pla2g10 phospholipase A2, group X JBrowse link 10 1,509,732 1,520,970 RGD:1582547
RGD:1600115
G Pla2g12a phospholipase A2, group XIIA JBrowse link 2 235,311,664 235,327,972 RGD:1624291
RGD:13792537
G Pla2g12b phospholipase A2, group XIIB JBrowse link 20 28,989,440 29,007,967 RGD:1600115
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:1302902
RGD:1624291
RGD:8553780
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:628361
RGD:13792537
RGD:1624291
G Pla2g2c phospholipase A2, group IIC JBrowse link 5 157,163,672 157,187,654 RGD:1600115
G Pla2g2d phospholipase A2, group IID JBrowse link 5 157,222,636 157,228,795 RGD:13792537
G Pla2g2f phospholipase A2, group IIF JBrowse link 5 157,192,047 157,217,265 RGD:1624291
RGD:13792537
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:1600115
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:633563
RGD:13792537
RGD:1624291
RGD:1600115
G Pla2g4b phospholipase A2 group IVB JBrowse link 3 111,824,919 111,833,526 RGD:1624291
RGD:13792537
G Pla2g4c phospholipase A2 group IVC JBrowse link 1 75,440,035 75,481,995 RGD:13792537
G Pla2g4d phospholipase A2 group IVD JBrowse link 3 112,040,827 112,061,847 RGD:1624291
RGD:13792537
G Pla2g4e phospholipase A2, group IVE JBrowse link 3 111,952,396 112,018,470 RGD:1624291
RGD:13792537
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:1624291
RGD:13792537
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:1624291
RGD:13792537
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:1600115
G Plaat1 phospholipase A and acyltransferase 1 JBrowse link 11 75,125,951 75,145,868 RGD:1624291
G Plaat3 phospholipase A and acyltransferase 3 JBrowse link 1 222,844,238 222,877,180 RGD:12790655
RGD:1624291
G Plaat5 phospholipase A and acyltransferase 5 JBrowse link 1 222,907,159 222,937,643 RGD:1624291
G Plb1 phospholipase B1 JBrowse link 6 25,375,699 25,507,108 RGD:6903950
RGD:13792537
G Pnpla3 patatin-like phospholipase domain containing 3 JBrowse link 7 125,034,760 125,056,165 RGD:1624291
G Proca1 protein interacting with cyclin A1 JBrowse link 10 65,454,451 65,469,491 RGD:1600115
calcium-dependent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC102546467 HERV-H LTR-associating protein 1-like JBrowse link 7 106,442,364 106,485,324 RGD:13792537
G Oc90 otoconin 90 JBrowse link 7 106,615,859 106,697,089 RGD:13792537
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:2303763
RGD:1624291
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:2303763
RGD:13792537
G Pla2g2c phospholipase A2, group IIC JBrowse link 5 157,163,672 157,187,654 RGD:69933
G Pla2g2d phospholipase A2, group IID JBrowse link 5 157,222,636 157,228,795 RGD:13792537
G Pla2g2f phospholipase A2, group IIF JBrowse link 5 157,192,047 157,217,265 RGD:13792537
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:1642483
RGD:13792537
G Pla2g4b phospholipase A2 group IVB JBrowse link 3 111,824,919 111,833,526 RGD:1624291
RGD:13792537
G Pla2g4c phospholipase A2 group IVC JBrowse link 1 75,440,035 75,481,995 RGD:13792537
G Pla2g4d phospholipase A2 group IVD JBrowse link 3 112,040,827 112,061,847 RGD:1624291
RGD:13792537
G Pla2g4e phospholipase A2, group IVE JBrowse link 3 111,952,396 112,018,470 RGD:13792537
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:1624291
RGD:13792537
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:61698
RGD:13792537
calcium-independent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pla2g15 phospholipase A2, group XV JBrowse link 19 38,129,666 38,146,958 RGD:1304489
RGD:1624291
G Pla2g4c phospholipase A2 group IVC JBrowse link 1 75,440,035 75,481,995 RGD:1624291
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:729507
G Pla2g7 phospholipase A2 group VII JBrowse link 9 19,935,754 19,978,013 RGD:1624291
G Pnpla8 patatin-like phospholipase domain containing 8 JBrowse link 6 64,224,870 64,288,465 RGD:1624291
G Prdx6 peroxiredoxin 6 JBrowse link 13 79,077,567 79,088,113 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19527
    catalytic activity 6039
      hydrolase activity 2608
        hydrolase activity, acting on ester bonds 781
          carboxylic ester hydrolase activity 156
            phospholipase A2 activity 31
              calcium-dependent phospholipase A2 activity 14
              calcium-independent phospholipase A2 activity 6
Path 2
Term Annotations click to browse term
  molecular_function 19527
    catalytic activity 6039
      hydrolase activity 2608
        hydrolase activity, acting on ester bonds 781
          lipase activity 120
            phospholipase activity 92
              phospholipase A2 activity 31
                calcium-dependent phospholipase A2 activity 14
                calcium-independent phospholipase A2 activity 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.