Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase A2 activity
go back to main search page
Accession:GO:0004623 term browser browse the term
Definition:Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Synonyms:exact_synonym: lecithinase A activity;   phosphatidolipase activity;   phosphatidylcholine 2-acylhydrolase activity
 narrow_synonym: cytosolic phospholipase A2 activity;   secreted phospholipase A2 activity
 related_synonym: phosphatidase activity;   phospholipase A
 xref: EC:3.1.1.4;   MetaCyc:PHOSPHOLIPASE-A2-RXN;   RHEA:15801;   reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";   reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";   reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";   reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";   reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";   reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";   reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";   reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";   reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";   reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";   reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";   reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";   reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";   reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";   reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";   reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";   reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";   reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";   reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";   reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";   reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";   reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";   reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";   reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";   reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane"


show annotations for term's descendants       view all columns           Sort by:
 
phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pla2g2a phospholipase A2 group IIA JBrowse link NW_004936474 6,091,978 6,095,961 RGD:9068941
G Pla2g4c phospholipase A2 group IVC JBrowse link NW_004936664 2,201,583 2,237,796 RGD:9068941
calcium-dependent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pla2g2a phospholipase A2 group IIA JBrowse link NW_004936474 6,091,978 6,095,961 RGD:9068941
G Pla2g4c phospholipase A2 group IVC JBrowse link NW_004936664 2,201,583 2,237,796 RGD:9068941
calcium-independent phospholipase A2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pla2g4c phospholipase A2 group IVC JBrowse link NW_004936664 2,201,583 2,237,796 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 324
    catalytic activity 83
      hydrolase activity 41
        hydrolase activity, acting on ester bonds 19
          carboxylic ester hydrolase activity 5
            phospholipase A2 activity 2
              calcium-dependent phospholipase A2 activity 2
              calcium-independent phospholipase A2 activity 1
Path 2
Term Annotations click to browse term
  molecular_function 324
    catalytic activity 83
      hydrolase activity 41
        hydrolase activity, acting on ester bonds 19
          lipase activity 4
            phospholipase activity 2
              phospholipase A2 activity 2
                calcium-dependent phospholipase A2 activity 2
                calcium-independent phospholipase A2 activity 1
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.