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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase C activity
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Accession:GO:0004629 term browser browse the term
Definition:Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
Synonyms:related_synonym: lecithinase C activity;   lipophosphodiesterase C;   phosphatidase C
 alt_id: GO:0042298
 xref: EC:3.1.4.3;   MetaCyc:PHOSPHOLIPASE-C-RXN;   reactome:R-HSA-1112666 "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate";   reactome:R-HSA-114688 "PLC-beta hydrolyses PIP2 to DAG and IP3";   reactome:R-HSA-114689 "PLC gamma 2-mediated PIP2 hydrolysis";   reactome:R-HSA-398193 "PLC beta-mediated PIP2 hydrolysis";   reactome:R-HSA-399998 "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate";   reactome:R-HSA-5362553 "NOTUM releases Hh-Np:GPC5 from the plasma membrane"


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phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcb2 phospholipase C, beta 2 IMP RGD PMID:9860142 RGD:729588 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Plcb3 phospholipase C beta 3 TAS RGD PMID:8454637 RGD:61699 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcd1 phospholipase C, delta 1 ISO (MGI:5520128|PMID:23892088) RGD PMID:23892088 MGI:5520128 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Plce1 phospholipase C, epsilon 1 ISO
ISS
(PMID:11022047)
GO_REF:0000024
RGD
UniProt
PMID:11022047 GO_REF:0000024 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Plch2 phospholipase C, eta 2 ISO (MGI:3590438|PMID:15899900) RGD PMID:15899900 MGI:3590438 NCBI chr 5:172,386,400...172,455,965
Ensembl chr 5:172,388,598...172,424,081
JBrowse link
G Plcz1 phospholipase C, zeta 1 ISO (MGI:2182519|PMID:12117804) RGD PMID:12117804 MGI:2182519 NCBI chr 4:174,125,072...174,181,524
Ensembl chr 4:174,125,178...174,180,729
JBrowse link
calcium-dependent phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcg1 phospholipase C, gamma 1 IDA PMID:7531435 UniProt PMID:7531435 RGD:39458025 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Plch1 phospholipase C, eta 1 ISO (PMID:15702972) RGD PMID:15702972 NCBI chr 2:154,256,382...154,468,166
Ensembl chr 2:154,256,380...154,418,920
JBrowse link
phosphatidylinositol phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 ISO
IEA
(PMID:10734056)
GO_REF:0000107
RGD
Ensembl
PMID:10734056 GO_REF:0000107 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 ISO (PMID:10734056) RGD PMID:10734056 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Plcb1 phospholipase C beta 1 IDA
IBA
ISO
IEA
PMID:21873635
(MGI:4943669|PMID:9762362)
(PMID:9188725)
GO_REF:0000003
RGD
UniProt
PMID:9188725, PMID:9762362, PMID:15159145, PMID:21873635 GO_REF:0000003, MGI:4943669, RGD:1582559, RGD:13792537 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb2 phospholipase C, beta 2 IEA
IBA
ISS
ISO
IMP
GO_REF:0000003
PMID:21873635
GO_REF:0000024
(PMID:8519600), (PMID:9188725)
PMID:9860142
UniProt
RGD
PMID:8519600, PMID:9188725, PMID:21873635, PMID:9860142 GO_REF:0000003, GO_REF:0000024, RGD:13792537, RGD:729588 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Plcb3 phospholipase C beta 3 IDA
IBA
ISO
IEA
PMID:8454637
PMID:21873635
(PMID:9188725)
GO_REF:0000003
RGD
UniProt
PMID:9188725, PMID:8454637, PMID:21873635 GO_REF:0000003, RGD:61699, RGD:13792537 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcb4 phospholipase C, beta 4 IEA
IBA
GO_REF:0000003
PMID:21873635
UniProt PMID:21873635 GO_REF:0000003, RGD:13792537 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Plcd1 phospholipase C, delta 1 IDA
IBA
ISO
IEA
PMID:21873635
(PMID:9188725)
GO_REF:0000003
RGD
UniProt
PMID:9188725, PMID:9287165, PMID:21873635 GO_REF:0000003, RGD:2301017, RGD:13792537 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Plcd3 phospholipase C, delta 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:91,164,778...91,186,067
Ensembl chr10:91,164,812...91,186,054
JBrowse link
G Plcd4 phospholipase C, delta 4 IDA
IBA
IEA
PMID:21873635
GO_REF:0000003
UniProt PMID:8550568, PMID:21873635 GO_REF:0000003, RGD:633664, RGD:13792537 NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364
JBrowse link
G Plce1 phospholipase C, epsilon 1 IDA
IBA
ISO
ISS
IEA
PMID:21873635
(PMID:11022047), (PMID:11022048)
GO_REF:0000024
GO_REF:0000003
RGD
UniProt
PMID:11022047, PMID:11022048, PMID:11179219, PMID:21873635 GO_REF:0000003, GO_REF:0000024, RGD:68714, RGD:13792537 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Plcg1 phospholipase C, gamma 1 IEA
ISO
IDA
TAS
GO_REF:0000003
(MGI:6218355|PMID:8615781)
PMID:7531435
(PMID:2550068)
Reactome:R-RNO-622387
Reactome:R-RNO-182061
UniProt
RGD
Reactome
PMID:2550068, PMID:8615781, PMID:7531435 GO_REF:0000003, MGI:6218355, Reactome:R-RNO-182061, Reactome:R-RNO-622387, RGD:39458025 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Plcg2 phospholipase C, gamma 2 IDA
ISO
IEA
(MGI:6218355|PMID:8615781)
(PMID:11606584), (PMID:12181444)
GO_REF:0000003
RGD
UniProt
PMID:8615781, PMID:11606584, PMID:12181444, PMID:2557343 GO_REF:0000003, MGI:6218355, RGD:69934 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
JBrowse link
G Plch1 phospholipase C, eta 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:154,256,382...154,468,166
Ensembl chr 2:154,256,380...154,418,920
JBrowse link
G Plch2 phospholipase C, eta 2 ISO
IBA
(PMID:18361507)
PMID:21873635
RGD PMID:18361507, PMID:21873635 RGD:13792537 NCBI chr 5:172,386,400...172,455,965
Ensembl chr 5:172,388,598...172,424,081
JBrowse link
G Plcl1 phospholipase C-like 1 IEA GO_REF:0000002
GO_REF:0000003
InterPro
UniProt
GO_REF:0000002, GO_REF:0000003 NCBI chr 9:62,016,112...62,349,244
Ensembl chr 9:62,291,405...62,349,309
JBrowse link
G Plcl2 phospholipase C-like 2 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:1,782,536...1,984,654
Ensembl chr 9:1,782,536...1,984,654
JBrowse link
G Plcz1 phospholipase C, zeta 1 ISO
IBA
(PMID:28270562)
PMID:21873635
(MGI:3037365|PMID:14701816)
RGD PMID:14701816, PMID:28270562, PMID:21873635 MGI:3037365, RGD:13792537 NCBI chr 4:174,125,072...174,181,524
Ensembl chr 4:174,125,178...174,180,729
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20471
    catalytic activity 6068
      hydrolase activity 2659
        hydrolase activity, acting on ester bonds 804
          phosphoric ester hydrolase activity 377
            phosphoric diester hydrolase activity 90
              phospholipase C activity 17
                calcium-dependent phospholipase C activity 2
                inositol phosphosphingolipid phospholipase activity + 0
                phosphatidylcholine phospholipase C activity 0
                phosphatidylglycerol phospholipase C activity 0
                phosphatidylinositol phospholipase C activity 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.