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ONTOLOGY REPORT - ANNOTATIONS


Term:polypeptide N-acetylgalactosaminyltransferase activity
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Accession:GO:0004653 term browser browse the term
Definition:Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.
Synonyms:related_synonym: UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity;   UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity;   UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity;   UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity;   UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity;   UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity;   UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity;   glycoprotein acetylgalactosaminyltransferase activity;   polypeptide-N-acetylgalactosamine transferase activity;   protein-UDP acetylgalactosaminyltransferase activity;   uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
 xref: EC:2.4.1.41;   MetaCyc:2.4.1.41-RXN;   Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to mucins";   Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins";   Reactome:R-HSA-9683760 "GalNAc is transferred onto 3a";   reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23";   reactome:R-HSA-913675 "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens"


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polypeptide N-acetylgalactosaminyltransferase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Galnt1 polypeptide N-acetylgalactosaminyltransferase 1 IMP
ISO
(MGI:MGI:2157773|PMID:11278534), (MGI:MGI:2676507|PMID:12407114)
(PMID:22186971), (PMID:9295285)
RGD PMID:9295285, PMID:11278534, PMID:12407114, PMID:22186971, PMID:12364335 MGI:MGI:2157773, MGI:MGI:2676507, RGD:727444 NCBI chr18:16,141,062...16,187,271
Ensembl chr18:16,146,447...16,185,496
JBrowse link
G Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 ISO (MGI:MGI:2157773|PMID:11278534)
(PMID:12417297), (PMID:18562306), (PMID:19460755)
RGD PMID:11278534, PMID:12417297, PMID:18562306, PMID:19460755 MGI:MGI:2157773 NCBI chr10:43,067,316...43,208,992
Ensembl chr10:43,067,299...43,210,427
JBrowse link
G Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 ISO
IEA
ISS
(PMID:24226769)
GO_REF:0000003
GO_REF:0000024
RGD
UniProt
PMID:24226769 GO_REF:0000003, GO_REF:0000024 NCBI chr 4:6,297,255...6,330,765
Ensembl chr 4:6,297,258...6,330,765
JBrowse link
G Galnt12 polypeptide N-acetylgalactosaminyltransferase 12 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:62,718,733...62,751,345
Ensembl chr 5:62,718,787...62,750,145
JBrowse link
G Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 ISO (MGI:MGI:2676507|PMID:12407114)
(PMID:22186971)
RGD PMID:12407114, PMID:22186971 MGI:MGI:2676507 NCBI chr 3:39,967,056...40,625,144
Ensembl chr 3:40,038,336...40,624,530
JBrowse link
G Galnt14 polypeptide N-acetylgalactosaminyltransferase 14 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:24,770,308...24,985,711
Ensembl chr 6:24,770,317...24,985,716
JBrowse link
G Galnt15 polypeptide N-acetylgalactosaminyltransferase 15 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr16:8,127,599...8,178,101
Ensembl chr16:8,128,689...8,177,841
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 ISO (PMID:22186971) RGD PMID:22186971 NCBI chr 6:104,069,853...104,250,177
Ensembl chr 6:104,068,547...104,250,174
JBrowse link
G Galnt18 polypeptide N-acetylgalactosaminyltransferase 18 ISO (PMID:22186971) RGD PMID:22186971 NCBI chr 1:176,296,186...176,607,466
Ensembl chr 1:176,296,193...176,607,466
JBrowse link
G Galnt2 polypeptide N-acetylgalactosaminyltransferase 2 ISO (PMID:12438318), (PMID:16434399), (PMID:18562306), (PMID:19460755), (PMID:9295285) RGD PMID:9295285, PMID:12438318, PMID:16434399, PMID:18562306, PMID:19460755 NCBI chr19:57,043,858...57,115,123
Ensembl chr19:57,047,830...57,115,132
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 ISO (PMID:9295285) RGD PMID:9295285 NCBI chr 3:52,174,469...52,212,395
Ensembl chr 3:52,175,547...52,212,412
JBrowse link
G Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 ISO (PMID:29208955), (PMID:9804815) RGD PMID:9804815, PMID:29208955 NCBI chr 7:41,305,437...41,309,621 JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 ISO (PMID:10545594) RGD PMID:10545594 NCBI chr 3:44,025,964...44,072,073
Ensembl chr 3:44,025,300...44,074,678
JBrowse link
G Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 ISO (MGI:MGI:1890147|PMID:10464263) RGD PMID:10464263 MGI:MGI:1890147 NCBI chr 7:142,322,172...142,364,281
Ensembl chr 7:142,322,172...142,352,382
JBrowse link
G Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 ISO (MGI:MGI:2157773|PMID:11278534) RGD PMID:11278534 MGI:MGI:2157773 NCBI chr16:35,935,059...36,062,734
Ensembl chr16:35,934,970...36,062,719
JBrowse link
G Galnt9 polypeptide N-acetylgalactosaminyltransferase 9 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:52,106,506...52,187,205
Ensembl chr12:52,106,506...52,187,164
JBrowse link
G Galntl6 polypeptide N-acetylgalactosaminyltransferase-like 6 ISO (PMID:22186971) RGD PMID:22186971 NCBI chr16:34,551,052...35,803,840
Ensembl chr16:35,573,058...35,802,979
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      catalytic activity, acting on a protein 2312
        polypeptide N-acetylgalactosaminyltransferase activity 17
Path 2
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      transferase activity 2353
        transferase activity, transferring glycosyl groups 281
          UDP-glycosyltransferase activity 145
            acetylgalactosaminyltransferase activity 46
              polypeptide N-acetylgalactosaminyltransferase activity 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.