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ONTOLOGY REPORT - ANNOTATIONS


Term:porphobilinogen synthase activity
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Accession:GO:0004655 term browser browse the term
Definition:Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen.
Synonyms:exact_synonym: aminolevulinate dehydratase activity;   delta-aminolevulinic acid dehydratase activity
 related_synonym: 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing);   5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming);   5-levulinic acid dehydratase activity;   aminolevulinic dehydratase activity;   delta-aminolevulinate dehydratase activity;   delta-aminolevulinic acid dehydrase activity;   delta-aminolevulinic dehydratase activity
 xref: EC:4.2.1.24;   KEGG_REACTION:R00036;   MetaCyc:PORPHOBILSYNTH-RXN;   RHEA:24064;   reactome:R-HSA-189439 "ALAD condenses 2 dALAs to form PBG"


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porphobilinogen synthase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase IDA
ISS
ISO
IBA
GO_REF:0000024
(PMID:11032836), (PMID:8175643)
PMID:21873635
(MGI:53493|PMID:4959158), (MGI:53609|PMID:4981581), (MGI:63121|PMID:14050799)
UniProt
RGD
PMID:4959158, PMID:4981581, PMID:8175643, PMID:11032836, PMID:14050799, PMID:19095280, PMID:21873635 GO_REF:0000024, MGI:53493, MGI:53609, MGI:63121, RGD:4144201, RGD:13792537 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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  molecular_function 20457
    catalytic activity 6065
      lyase activity 212
        carbon-oxygen lyase activity 92
          hydro-lyase activity 71
            porphobilinogen synthase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.