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Term:protein serine/threonine/tyrosine kinase activity
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Accession:GO:0004712 term browser browse the term
Definition:Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Synonyms:exact_synonym: ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity
 narrow_synonym: Arabidopsis dual specificity kinase 1 activity;   protein threonine/tyrosine kinase activity
 broad_synonym: dual-specificity kinase activity;   dual-specificity protein kinase
 related_synonym: ADK1;   CLK1;   Mps1p;   dDYRK2
 xref: EC:2.7.12.1;   reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5";   reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3";   reactome:R-HSA-5672969 "Phosphorylation of RAF";   reactome:R-HSA-5674373 "MAP2Ks phosphorylate MAPK at the Golgi membrane";   reactome:R-HSA-6802910 "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants";   reactome:R-HSA-6802916 "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants";   reactome:R-HSA-6802918 "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants";   reactome:R-HSA-6802921 "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants";   reactome:R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS";   reactome:R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS";   reactome:R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated";   reactome:R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF"


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protein serine/threonine/tyrosine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr2b activin A receptor type 2B JBrowse link 8 128,087,308 128,126,776 RGD:1624291
RGD:1600115
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
RGD:1600115
G Clk3 CDC-like kinase 3 JBrowse link 8 62,528,135 62,543,550 RGD:1600115
G Dstyk dual serine/threonine and tyrosine protein kinase JBrowse link 13 49,195,325 49,243,327 RGD:1600115
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A JBrowse link 11 34,858,339 34,958,733 RGD:1600115
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 JBrowse link 13 47,906,230 47,916,877 RGD:1600115
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:8553538
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:8553538
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:1624291
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:1600115
RGD:1624291
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:1624291
RGD:1600115
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:1624291
RGD:1600115
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:1624291
RGD:1600115
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:1624291
RGD:1600115
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:1624291
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:1624291
RGD:1600115
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:1624291
RGD:1600115
G Tesk1 testis associated actin remodelling kinase 1 JBrowse link 5 58,937,615 58,943,358 RGD:1600115
G Tesk2 testis associated actin remodelling kinase 2 JBrowse link 5 135,574,172 135,659,842 RGD:1600115
G Tnk2 tyrosine kinase, non-receptor, 2 JBrowse link 11 71,348,726 71,388,520 RGD:1600115
RGD:1624291
G Ttk Ttk protein kinase JBrowse link 8 91,368,065 91,405,995 RGD:1624291
RGD:1600115
JUN kinase kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:2293351
RGD:13792537
RGD:2298708
RGD:2298577
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:2298561
RGD:2298565
RGD:2298577
RGD:13792537
MAP kinase kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:1600115
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:70317
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2298674
RGD:61657
RGD:1582177
RGD:2293305
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:61657
RGD:13792537
RGD:1624291
RGD:2298674
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:1624291
RGD:13792537
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:2293351
RGD:13792537
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:61658
RGD:13792537
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:7243113
RGD:13792537
RGD:1624291
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:7243113
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2298561
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:1624291
RGD:1600115
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1624291
RGD:1600115
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18225
    catalytic activity 5794
      catalytic activity, acting on a protein 2193
        protein kinase activity 608
          protein serine/threonine/tyrosine kinase activity 31
            MAP kinase kinase activity + 12
Path 2
Term Annotations click to browse term
  molecular_function 18225
    catalytic activity 5794
      transferase activity 2266
        transferase activity, transferring phosphorus-containing groups 953
          kinase activity 805
            protein kinase activity 608
              protein serine/threonine/tyrosine kinase activity 31
                MAP kinase kinase activity + 12
paths to the root