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Term:protein tyrosine kinase activity
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Accession:GO:0004713 term browser browse the term
Definition:Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Synonyms:narrow_synonym: JAK;   Janus kinase activity
 alt_id: GO:0004718
 xref: EC:2.7.10;   Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes";   Reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes";   Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15";   Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2";   Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src";   Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397";   Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC";   Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex";   Reactome:R-HSA-389762 "Phosphorylation of PD-1";   Reactome:R-HSA-418163 "Activated Src activates ERK";   Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK";   Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1";   Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6";   Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18";   Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC";   Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC";   Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4";   Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates";   Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR";   reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1";   reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma";   reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation";   reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers";   reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants";   reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants";   reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants";   reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers";   reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers";   reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers";   reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers";   reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2";   reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5";   reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227";   reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4";   reactome:R-HSA-1433418 "Phosphorylation of JAK2";   reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs";   reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs";   reactome:R-HSA-1433506 "Phosphorylation of APS";   reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1";   reactome:R-HSA-1470009 "Phosphorylation of STATs";   reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR";   reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated";   reactome:R-HSA-170991 "SRC-1 autophosphorylates";   reactome:R-HSA-171011 "Binding and activation of MAP Kinase";   reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase";   reactome:R-HSA-177934 "EGFR autophosphorylation";   reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase";   reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)";   reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)";   reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers";   reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1";   reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1";   reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions";   reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors";   reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3";   reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4";   reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b";   reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c";   reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b";   reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c";   reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b";   reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c";   reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c";   reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers";   reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers";   reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2";   reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1";   reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant";   reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants";   reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant";   reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes";   reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck";   reactome:R-HSA-202174 "Activation of ZAP-70";   reactome:R-HSA-202216 "Phosphorylation of SLP-76";   reactome:R-HSA-202233 "Inactivation of Lck by Csk";   reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT";   reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1";   reactome:R-HSA-202291 "Activation of Lck";   reactome:R-HSA-202307 "Change of PKC theta conformation";   reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers";   reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity";   reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG";   reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases";   reactome:R-HSA-2029453 "Phosphorylation of VAV";   reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts";   reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants";   reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants";   reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity";   reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding";   reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding";   reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity";   reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants";   reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity";   reactome:R-HSA-205289 "Autophosphorylation of KIT";   reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src";   reactome:R-HSA-210872 "Trans-phosphorylation of Tie2";   reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation";   reactome:R-HSA-2130194 "ABL phosphorylates WAVEs";   reactome:R-HSA-2197698 "Phosphorylation of WASP/N-WASP";   reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK";   reactome:R-HSA-2395412 "Phosphorylation of SYK";   reactome:R-HSA-2395439 "Phosphorylation of DAP12";   reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK";   reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK";   reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1";   reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates";   reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK";   reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK";   reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK";   reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4";   reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN";   reactome:R-HSA-2454239 "Phosphorylation of SYK";   reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR";   reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin";   reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin";   reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin";   reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin";   reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK";   reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK";   reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK";   reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK";   reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN";   reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase";   reactome:R-HSA-2730882 "Phosphorylation of PKC-theta";   reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn";   reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase";   reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma";   reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F";   reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN";   reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2";   reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn";   reactome:R-HSA-377640 "Autophosphorylation of SRC";   reactome:R-HSA-380780 "Activation of Src";   reactome:R-HSA-388831 "Phosphorylation of CD28";   reactome:R-HSA-388833 "Phosphorylation of CTLA-4";   reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors";   reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors";   reactome:R-HSA-389354 "Activation of Vav1";   reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha";   reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts";   reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase";   reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn";   reactome:R-HSA-3928578 "EPH receptors autophosphorylate";   reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs";   reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B";   reactome:R-HSA-3928594 "SFKs phosphorylate GIT1";   reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3";   reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397";   reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1";   reactome:R-HSA-3928648 "SFKs phosphorylate NGEF";   reactome:R-HSA-399934 "Phosphorylation of Plexin-A";   reactome:R-HSA-399946 "Recruitment and activation of Cdk5";   reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes";   reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2";   reactome:R-HSA-418859 "Phosphorylation of Unc5C";   reactome:R-HSA-418872 "Phosphorylation of FADK1";   reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met";   reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase";   reactome:R-HSA-429441 "SYK activation by SRC";   reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation";   reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8";   reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT";   reactome:R-HSA-4420117 "VEGFR2 autophosphorylates";   reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1";   reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB";   reactome:R-HSA-4420206 "Phosphorylation of SRC-1";   reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2";   reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1";   reactome:R-HSA-445084 "Phosphorylation of L1 by SRC";   reactome:R-HSA-445085 "Phosphorylation of VAV2";   reactome:R-HSA-445091 "Phosphorylation of Neurofascin";   reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1";   reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated";   reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated";   reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB";   reactome:R-HSA-508282 "SYK is a substrate for JAK1";   reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2";   reactome:R-HSA-5218642 "PTK2 autophosphorylates";   reactome:R-HSA-5218806 "FYN autophosphorylates";   reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118";   reactome:R-HSA-5218812 "FYN phosphorylates PAK2";   reactome:R-HSA-5218820 "Src kinases phosphorylate VAV";   reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1";   reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta";   reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407";   reactome:R-HSA-5357429 "AXL autophosphorylates on Y772 and Y814";   reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG";   reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan";   reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG";   reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2";   reactome:R-HSA-5621370 "SYK autophosphorylates";   reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341";   reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant";   reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII";   reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1";   reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1";   reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1";   reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1";   reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2";   reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1";   reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2";   reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2";   reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1";   reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c";   reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2";   reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3";   reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1";   reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11";   reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3";   reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11";   reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3";   reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11";   reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1";   reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3";   reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11";   reactome:R-HSA-5655243 "Activated FGFR3 mutants phosphorylate PLCG1";   reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2";   reactome:R-HSA-5655270 "Activated FGFR3 mutants phosphorylate FRS2";   reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2";   reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2";   reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1";   reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1";   reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142";   reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52";   reactome:R-HSA-5690702 "LYN phosphorylates CD22";   reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2";   reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2";   reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation";   reactome:R-HSA-6806974 "MET dimers autophosphorylate";   reactome:R-HSA-873918 "Transphosphorylation of JAK1";   reactome:R-HSA-873919 "Phosphorylation of JAK2";   reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases";   reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases";   reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor";   reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2";   reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated";   reactome:R-HSA-8847977 "FRK phosphorylates PTEN";   reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation";   reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2";   reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3";   reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B";   reactome:R-HSA-8848606 "PTK6 phosphorylates PXN";   reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1";   reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1";   reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1";   reactome:R-HSA-8848818 "PTK6 phosphorylates CBL";   reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1";   reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1";   reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2";   reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3";   reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35";   reactome:R-HSA-8849102 "SRMS phosphorylates PTK6";   reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ";   reactome:R-HSA-8851890 "MET phosphorylates SHC1-2";   reactome:R-HSA-8851933 "MET phosphorylates GAB1";   reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions";   reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate";   reactome:R-HSA-8853315 "Activated FGFR3 fusions phosphorylate FRS2";   reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate";   reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1";   reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB";   reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation";   reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307";   reactome:R-HSA-8867041 "EGFR phosphorylates EPS15";   reactome:R-HSA-8874078 "PTK2 autophosphorylates";   reactome:R-HSA-8874080 "SRC phosphorylates PTK2";   reactome:R-HSA-8874082 "MET phosphorylates PTK2";   reactome:R-HSA-8875451 "MET phosphorylates CBL";   reactome:R-HSA-8875817 "MET phosphorylates STAT3";   reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates";   reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL";   reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1";   reactome:R-HSA-8937728 "SRC phosphorylates RUNX1";   reactome:R-HSA-8937807 "SRC phosphorylates RUNX3";   reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1";   reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes";   reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1";   reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR";   reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin";   reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1";   reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2";   reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3";   reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1";   reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate";   reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate";   reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate";   reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1";   reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1";   reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2";   reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1";   reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2";   reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2";   reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1";   reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1";   reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3";   reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates";   reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B";   reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5";   reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation";   reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate";   reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1";   reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1";   reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2";   reactome:R-HSA-909718 "Formation of p-STAT1 homodimer";   reactome:R-HSA-909726 "Phosphorylation of STAT1";   reactome:R-HSA-909729 "Activation of JAK kinases";   reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2";   reactome:R-HSA-909732 "Phosphorylation of STAT2";   reactome:R-HSA-912629 "CBL is tyrosine phosphorylated";   reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation";   reactome:R-HSA-9606159 "BTK autophosphorylates";   reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2";   reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK";   reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs";   reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates";   reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates";   reactome:R-HSA-982807 "JAK2 phosphorylation of GHR";   reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)";   reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR";   reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)"


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protein tyrosine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aatk apoptosis-associated tyrosine kinase JBrowse link 10 109,184,338 109,224,455 RGD:1624291
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1624291
G Alk ALK receptor tyrosine kinase JBrowse link 6 22,696,415 23,203,791 RGD:1624291
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
G Baz1b bromodomain adjacent to zinc finger domain, 1B JBrowse link 12 24,478,882 24,536,851 RGD:1624291
RGD:1600115
G Blk BLK proto-oncogene, Src family tyrosine kinase JBrowse link 15 46,555,552 46,593,778 RGD:1624291
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:1600538
RGD:1624291
G Clk1 CDC-like kinase 1 JBrowse link 9 65,296,777 65,308,017 RGD:1624291
RGD:1600115
G Clk2 CDC-like kinase 2 JBrowse link 2 188,476,789 188,488,809 RGD:1624291
G Clk3 CDC-like kinase 3 JBrowse link 8 62,528,135 62,543,550 RGD:1624291
RGD:1600115
G Clk4 CDC-like kinase 4 JBrowse link 10 36,715,565 36,733,473 RGD:1624291
G Csk C-terminal Src kinase JBrowse link 8 62,405,714 62,424,707 RGD:5134374
G Dstyk dual serine/threonine and tyrosine protein kinase JBrowse link 13 49,195,325 49,243,327 RGD:1600115
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A JBrowse link 11 34,858,339 34,958,733 RGD:728738
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link 7 61,785,423 61,816,775 RGD:1624291
RGD:1600115
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 JBrowse link 13 47,906,230 47,916,877 RGD:1600115
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:10395247
RGD:1624291
G Epha7 Eph receptor A7 JBrowse link 5 43,602,744 43,761,198 RGD:8554504
G Ephb1 Eph receptor B1 JBrowse link 8 110,376,954 110,813,193 RGD:632706
RGD:632705
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:1582128
RGD:1624291
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:1624291
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:1624291
G Fes FES proto-oncogene, tyrosine kinase JBrowse link 1 142,174,648 142,183,884 RGD:1624291
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:1624291
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:1624291
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:1302342
RGD:1624291
G Flt3 fms-related tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:1624291
G Frk fyn-related Src family tyrosine kinase JBrowse link 20 41,266,408 41,383,731 RGD:632737
RGD:1624291
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:625575
RGD:1624291
RGD:1600115
RGD:13506268
RGD:2303644
RGD:632732
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:1600115
RGD:1624291
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:12904886
RGD:1624291
RGD:1600115
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2307023
RGD:1624291
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:1624291
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1641883
RGD:1624291
RGD:1600115
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1624291
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:2292489
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:1600230
RGD:1624291
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:625575
RGD:1624291
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:1600115
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:1600115
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:1600115
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:1600115
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:729166
G Musk muscle associated receptor tyrosine kinase JBrowse link 5 75,392,790 75,498,694 RGD:2317112
RGD:8553282
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:8553977
RGD:1624291
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:1600115
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:628442
RGD:1624291
RGD:8553998
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:729733
RGD:1624291
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1624291
G Ptk6 protein tyrosine kinase 6 JBrowse link 3 176,698,305 176,706,896 RGD:1624291
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase JBrowse link 20 33,100,190 33,323,544 RGD:1624291
RGD:1600115
G Ryk receptor-like tyrosine kinase JBrowse link 8 111,326,339 111,398,640 RGD:1624291
G Shc3 SHC adaptor protein 3 JBrowse link 17 13,670,520 13,791,043 RGD:1600115
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:634205
RGD:1624291
RGD:1600115
G Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites JBrowse link 3 176,709,742 176,716,146 RGD:1624291
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:11059586
RGD:1624291
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:1624291
G Tesk1 testis associated actin remodelling kinase 1 JBrowse link 5 58,937,615 58,943,358 RGD:1600115
G Tesk2 testis associated actin remodelling kinase 2 JBrowse link 5 135,574,172 135,659,842 RGD:1600115
G Tnk1 tyrosine kinase, non-receptor, 1 JBrowse link 10 56,458,650 56,475,183 RGD:1624291
G Tnk2 tyrosine kinase, non-receptor, 2 JBrowse link 11 71,348,726 71,388,520 RGD:8554454
RGD:1624291
RGD:1600115
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:1624291
G Twf1 twinfilin actin-binding protein 1 JBrowse link 7 135,838,647 135,850,542 RGD:1624291
RGD:1600115
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:1624291
G Tyro3 TYRO3 protein tyrosine kinase JBrowse link 3 111,597,102 111,616,142 RGD:1624291
RGD:1600115
G Wee1 WEE1 G2 checkpoint kinase JBrowse link 1 174,765,228 174,790,882 RGD:13792537
G Wee2 WEE1 homolog 2 JBrowse link 4 68,604,770 68,631,341 RGD:13792537
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase JBrowse link 9 121,802,471 121,918,906 RGD:634514
RGD:1624291
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291
brain-derived neurotrophic factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:8554777
RGD:8554094
RGD:1600115
RGD:1624291
RGD:13792537
ephrin receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epha3 Eph receptor A3 JBrowse link 11 421,253 783,037 RGD:1624291
RGD:1600115
G Epha5 EPH receptor A5 JBrowse link 14 25,589,312 25,958,258 RGD:8554330
RGD:1600115
G Epha7 Eph receptor A7 JBrowse link 5 43,602,744 43,761,198 RGD:70732
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
G Ephb3 Eph receptor B3 JBrowse link 11 83,527,960 83,546,742 RGD:1624291
G Ephb4 EPH receptor B4 JBrowse link 12 22,393,338 22,418,332 RGD:1624291
epidermal growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efemp1 EGF containing fibulin extracellular matrix protein 1 JBrowse link 14 113,202,382 113,294,993 RGD:1600115
RGD:1624291
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:625656
RGD:13792537
RGD:1624291
RGD:1581908
RGD:70386
G Nrg2 neuregulin 2 JBrowse link 18 28,835,391 29,015,552 RGD:1304015
fibroblast growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:728839
RGD:13792537
RGD:1624291
RGD:1600115
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:632663
RGD:13792537
RGD:1624291
RGD:6480435
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:632790
RGD:13792537
RGD:1624291
RGD:1304345
G Fgfr4 fibroblast growth factor receptor 4 JBrowse link 17 9,990,072 10,004,339 RGD:1624291
RGD:13792537
G Fgfrl1 fibroblast growth factor receptor-like 1 JBrowse link 14 2,020,110 2,032,169 RGD:1624291
RGD:13792537
GPI-linked ephrin receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epha3 Eph receptor A3 JBrowse link 11 421,253 783,037 RGD:1600115
RGD:1624291
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:1600115
RGD:1624291
G Epha5 EPH receptor A5 JBrowse link 14 25,589,312 25,958,258 RGD:1600115
RGD:1624291
G Epha7 Eph receptor A7 JBrowse link 5 43,602,744 43,761,198 RGD:1624291
RGD:1600115
G Epha8 Eph receptor A8 JBrowse link 5 155,293,731 155,321,016 RGD:1600115
RGD:1624291
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:8553786
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:8553786
hepatocyte growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:2317458
RGD:13792537
RGD:1624291
histone kinase activity (H3-Y41 specific) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1624291
RGD:13792537
RGD:1600115
insulin-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:13792537
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:1580595
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2293184
RGD:1600765
RGD:1299201
G Insrr insulin receptor-related receptor JBrowse link 2 187,161,817 187,181,400 RGD:13792537
G LOC259246 alpha-2u globulin PGCL1 RGD:1600115
insulin-like growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:70266
RGD:1600115
RGD:1624291
RGD:12904886
G Igf2r insulin-like growth factor 2 receptor JBrowse link 1 48,176,095 48,264,482 RGD:1298967
macrophage colony-stimulating factor receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csf1r colony stimulating factor 1 receptor JBrowse link 18 56,414,493 56,458,300 RGD:1600115
RGD:13792537
RGD:1624291
non-membrane spanning protein tyrosine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
RGD:13792537
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:13792537
G Blk BLK proto-oncogene, Src family tyrosine kinase JBrowse link 15 46,555,552 46,593,778 RGD:1624291
RGD:13792537
G Bmx BMX non-receptor tyrosine kinase JBrowse link X 31,976,231 32,046,326 RGD:1624291
RGD:13792537
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:1600115
RGD:13792537
G Csk C-terminal Src kinase JBrowse link 8 62,405,714 62,424,707 RGD:1600115
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A JBrowse link 11 34,858,339 34,958,733 RGD:1624291
RGD:1600115
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:1600115
G Fer FER tyrosine kinase JBrowse link 9 111,557,804 111,868,583 RGD:1600115
RGD:13792537
RGD:1624291
G Fes FES proto-oncogene, tyrosine kinase JBrowse link 1 142,174,648 142,183,884 RGD:1624291
RGD:13792537
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:1624291
RGD:13792537
G Frk fyn-related Src family tyrosine kinase JBrowse link 20 41,266,408 41,383,731 RGD:13792537
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:1600115
RGD:13792537
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:13792537
G Itk IL2-inducible T-cell kinase JBrowse link 10 31,431,820 31,493,413 RGD:1624291
RGD:13792537
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:1600115
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1600115
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1600115
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:1600115
RGD:13792537
G LOC100909750 tyrosine-protein kinase ABL1-like JBrowse link 3 9,409,199 9,448,254 RGD:13792537
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:13792537
G Matk megakaryocyte-associated tyrosine kinase JBrowse link 7 11,325,246 11,334,311 RGD:13792537
G Melk maternal embryonic leucine zipper kinase JBrowse link 5 59,783,835 59,844,356 RGD:1624291
RGD:13792537
G Peak1 pseudopodium-enriched atypical kinase 1 JBrowse link 8 60,861,742 61,080,128 RGD:1624291
RGD:1600115
G Pkdcc protein kinase domain containing, cytoplasmic JBrowse link 6 6,427,657 6,436,974 RGD:1624291
RGD:1600115
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:1600115
RGD:13792537
RGD:1624291
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1624291
RGD:13792537
RGD:1600115
G Ptk6 protein tyrosine kinase 6 JBrowse link 3 176,698,305 176,706,896 RGD:1624291
RGD:13792537
G Sla src-like adaptor JBrowse link 7 107,585,055 107,604,950 RGD:13792537
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:13792537
G Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites JBrowse link 3 176,709,742 176,716,146 RGD:13792537
G Stk16 serine/threonine kinase 16 JBrowse link 9 82,411,010 82,414,249 RGD:1600115
G Styk1 serine/threonine/tyrosine kinase 1 JBrowse link 4 165,528,027 165,543,365 RGD:13792537
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
G Tec tec protein tyrosine kinase JBrowse link 14 37,918,884 38,027,953 RGD:1624291
RGD:13792537
G Tnk1 tyrosine kinase, non-receptor, 1 JBrowse link 10 56,458,650 56,475,183 RGD:1624291
RGD:13792537
G Tnk2 tyrosine kinase, non-receptor, 2 JBrowse link 11 71,348,726 71,388,520 RGD:13792537
G Txk TXK tyrosine kinase JBrowse link 14 38,029,809 38,085,822 RGD:13792537
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:1600115
G Wee1 WEE1 G2 checkpoint kinase JBrowse link 1 174,765,228 174,790,882 RGD:1600115
G Wee2 WEE1 homolog 2 JBrowse link 4 68,604,770 68,631,341 RGD:1600115
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase JBrowse link 9 121,802,471 121,918,906 RGD:1600115
RGD:13792537
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1600115
placental growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:1600115
RGD:1624291
platelet-derived growth factor alpha-receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:729439
RGD:13792537
RGD:1600115
RGD:1624291
platelet-derived growth factor beta-receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:1600115
RGD:13792537
RGD:1624291
platelet-derived growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:628442
RGD:13792537
RGD:1581762
RGD:633648
protein tyrosine kinase collagen receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddr1 discoidin domain receptor tyrosine kinase 1 JBrowse link 20 3,553,430 3,574,959 RGD:1600115
RGD:13792537
RGD:1624291
G Ddr2 discoidin domain receptor tyrosine kinase 2 JBrowse link 13 88,311,639 88,436,561 RGD:1624291
RGD:13792537
stem cell factor receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:1624291
RGD:1600115
transmembrane receptor protein tyrosine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alk ALK receptor tyrosine kinase JBrowse link 6 22,696,415 23,203,791 RGD:1624291
RGD:13792537
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:13792537
G Csf1r colony stimulating factor 1 receptor JBrowse link 18 56,414,493 56,458,300 RGD:1624291
RGD:13792537
RGD:1600115
G Ddr1 discoidin domain receptor tyrosine kinase 1 JBrowse link 20 3,553,430 3,574,959 RGD:13792537
G Ddr2 discoidin domain receptor tyrosine kinase 2 JBrowse link 13 88,311,639 88,436,561 RGD:1624291
RGD:13792537
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:13792537
G Epha1 Eph receptor A1 JBrowse link 4 71,749,100 71,763,681 RGD:13792537
G Epha10 EPH receptor A10 JBrowse link 5 142,875,171 142,910,537 RGD:13792537
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
RGD:13792537
G Epha3 Eph receptor A3 JBrowse link 11 421,253 783,037 RGD:13792537
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:13792537
G Epha5 EPH receptor A5 JBrowse link 14 25,589,312 25,958,258 RGD:13792537
G Epha6 Eph receptor A6 JBrowse link 11 41,867,607 42,843,800 RGD:13792537
G Epha7 Eph receptor A7 JBrowse link 5 43,602,744 43,761,198 RGD:13792537
G Epha8 Eph receptor A8 JBrowse link 5 155,293,731 155,321,016 RGD:13792537
G Ephb1 Eph receptor B1 JBrowse link 8 110,376,954 110,813,193 RGD:13792537
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:13792537
G Ephb3 Eph receptor B3 JBrowse link 11 83,527,960 83,546,742 RGD:13792537
G Ephb4 EPH receptor B4 JBrowse link 12 22,393,338 22,418,332 RGD:1624291
RGD:13792537
G Ephb6 Eph receptor B6 JBrowse link 4 70,903,253 70,918,514 RGD:13792537
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:1624291
RGD:13792537
RGD:1600115
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:68774
RGD:13792537
RGD:1600115
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:1600115
RGD:13792537
RGD:1624291
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:13792537
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:13792537
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:13792537
G Fgfr4 fibroblast growth factor receptor 4 JBrowse link 17 9,990,072 10,004,339 RGD:13792537
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:1626619
RGD:13792537
G Flt3 fms-related tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:13792537
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1624291
RGD:13792537
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:13792537
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:1600115
RGD:13792537
G Insrr insulin receptor-related receptor JBrowse link 2 187,161,817 187,181,400 RGD:1624291
RGD:13792537
RGD:1600115
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:13792537
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:1624291
RGD:13792537
G Lmtk2 lemur tyrosine kinase 2 JBrowse link 12 12,409,876 12,546,111 RGD:13792537
G LOC102552659 receptor tyrosine-protein kinase erbB-2-like JBrowse link 10 84,839,053 84,845,803 RGD:1600115
G Ltk leukocyte receptor tyrosine kinase JBrowse link 3 111,553,679 111,560,556 RGD:13792537
G Mertk MER proto-oncogene, tyrosine kinase JBrowse link 3 121,235,230 121,340,932 RGD:1299193
RGD:13792537
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:13792537
RGD:1600115
G Mst1r macrophage stimulating 1 receptor JBrowse link 8 116,686,601 116,700,132 RGD:13792537
G Musk muscle associated receptor tyrosine kinase JBrowse link 5 75,392,790 75,498,694 RGD:13792537
RGD:1600115
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:1600115
RGD:13792537
RGD:1624291
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:1626134
RGD:13792537
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:13792537
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:1624291
RGD:13792537
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:13792537
G Ptk7 protein tyrosine kinase 7 JBrowse link 9 16,662,588 16,729,888 RGD:1624291
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:1624291
RGD:13792537
G Ror1 receptor tyrosine kinase-like orphan receptor 1 JBrowse link 5 118,892,874 119,239,528 RGD:13792537
G Ror2 receptor tyrosine kinase-like orphan receptor 2 JBrowse link 17 11,953,552 12,134,386 RGD:13792537
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase JBrowse link 20 33,100,190 33,323,544 RGD:13792537
G Ryk receptor-like tyrosine kinase JBrowse link 8 111,326,339 111,398,640 RGD:13792537
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:13792537
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 JBrowse link 5 137,294,544 137,321,116 RGD:13792537
G Tyro3 TYRO3 protein tyrosine kinase JBrowse link 3 111,597,102 111,616,142 RGD:13792537
RGD:1600115
transmembrane-ephrin receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epha1 Eph receptor A1 JBrowse link 4 71,749,100 71,763,681 RGD:1624291
RGD:13792537
G Epha10 EPH receptor A10 JBrowse link 5 142,875,171 142,910,537 RGD:1624291
RGD:13792537
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:13792537
G Epha3 Eph receptor A3 JBrowse link 11 421,253 783,037 RGD:13792537
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:1624291
RGD:13792537
RGD:1600115
G Epha5 EPH receptor A5 JBrowse link 14 25,589,312 25,958,258 RGD:13792537
G Epha6 Eph receptor A6 JBrowse link 11 41,867,607 42,843,800 RGD:13792537
G Epha7 Eph receptor A7 JBrowse link 5 43,602,744 43,761,198 RGD:13792537
G Epha8 Eph receptor A8 JBrowse link 5 155,293,731 155,321,016 RGD:13792537
G Ephb1 Eph receptor B1 JBrowse link 8 110,376,954 110,813,193 RGD:1624291
RGD:13792537
RGD:1600115
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
RGD:13792537
G Ephb3 Eph receptor B3 JBrowse link 11 83,527,960 83,546,742 RGD:13792537
G Ephb4 EPH receptor B4 JBrowse link 12 22,393,338 22,418,332 RGD:13792537
G Ephb6 Eph receptor B6 JBrowse link 4 70,903,253 70,918,514 RGD:13792537
vascular endothelial growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:1626621
RGD:13792537
RGD:1624291
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:727326
RGD:13792537
RGD:1624291
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:729081
RGD:1600115
RGD:13792537
RGD:1624291
RGD:1626621
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:1624291
RGD:1600115
G Nrp2 neuropilin 2 JBrowse link 9 69,496,875 69,609,802 RGD:1600115
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:1624291
RGD:1600115
VEGF-A-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:1600115
RGD:1624291
VEGF-B-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:1600115
RGD:1624291
VEGF-C-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18247
    catalytic activity 5761
      catalytic activity, acting on a protein 2193
        protein kinase activity 609
          protein tyrosine kinase activity 124
            non-membrane spanning protein tyrosine kinase activity + 43
            transmembrane receptor protein tyrosine kinase activity + 63
Path 2
Term Annotations click to browse term
  molecular_function 18247
    catalytic activity 5761
      transferase activity 2274
        transferase activity, transferring phosphorus-containing groups 956
          kinase activity 807
            protein kinase activity 609
              protein tyrosine kinase activity 124
                non-membrane spanning protein tyrosine kinase activity + 43
                transmembrane receptor protein tyrosine kinase activity + 63
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.