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ONTOLOGY REPORT - ANNOTATIONS


Term:non-membrane spanning protein tyrosine kinase activity
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Accession:GO:0004715 term browser browse the term
Definition:Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
Synonyms:exact_synonym: ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity;   non-specific protein-tyrosine kinase activity
 narrow_synonym: Bruton's tyrosine kinase activity;   cytoplasmic protein tyrosine kinase activity;   focal adhesion kinase activity;   janus kinase 1 activity;   janus kinase 2 activity;   janus kinase 3 activity;   p60c-src protein tyrosine kinase activity
 broad_synonym: ATP:protein-tyrosine O-phosphotransferase activity
 xref: EC:2.7.10.2;   MetaCyc:2.7.10.2-RXN;   reactome:R-HSA-1112602 "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor";   reactome:R-HSA-1112703 "PTPN11 is phosphorylated";   reactome:R-HSA-1168423 "JAK2 phosphorylation of IRS-1/2";   reactome:R-HSA-1168459 "Lyn activates ERK";   reactome:R-HSA-1168767 "JAK2 phosphorylates STAT1/STAT3";   reactome:R-HSA-1295519 "IL7R is phosphorylated on Y499";   reactome:R-HSA-1369115 "SHP2 is phosphorylated";   reactome:R-HSA-432148 "Fgr may phosphorylate p38 MAPK";   reactome:R-HSA-437936 "p-Y348-SYK phosphorylates VAV family";   reactome:R-HSA-453200 "SYK autophosphorylates";   reactome:R-HSA-6786095 "JAK1 phosphorylates STAT3,STAT6";   reactome:R-HSA-6786096 "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated";   reactome:R-HSA-6788582 "STAT1,STAT3,STAT6 phosphorylation";   reactome:R-HSA-879910 "JAK2 is phosphorylated, activated";   reactome:R-HSA-8871373 "BMX phosphorylates RUFY1"


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non-membrane spanning protein tyrosine kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
RGD:13792537
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:13792537
G Blk BLK proto-oncogene, Src family tyrosine kinase JBrowse link 15 46,555,552 46,593,778 RGD:1624291
RGD:13792537
G Bmx BMX non-receptor tyrosine kinase JBrowse link X 31,976,231 32,046,326 RGD:1624291
RGD:13792537
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:1600115
RGD:13792537
G Csk C-terminal Src kinase JBrowse link 8 62,405,714 62,424,707 RGD:1600115
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A JBrowse link 11 34,858,339 34,958,733 RGD:1624291
RGD:1600115
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:1600115
G Fer FER tyrosine kinase JBrowse link 9 111,557,804 111,868,583 RGD:1600115
RGD:13792537
RGD:1624291
G Fes FES proto-oncogene, tyrosine kinase JBrowse link 1 142,174,648 142,183,884 RGD:1624291
RGD:13792537
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:1624291
RGD:13792537
G Frk fyn-related Src family tyrosine kinase JBrowse link 20 41,266,408 41,383,731 RGD:13792537
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:1600115
RGD:13792537
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:13792537
G Itk IL2-inducible T-cell kinase JBrowse link 10 31,431,820 31,493,413 RGD:1624291
RGD:13792537
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:1600115
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1600115
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1600115
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:1600115
RGD:13792537
G LOC100909750 tyrosine-protein kinase ABL1-like JBrowse link 3 9,409,199 9,448,254 RGD:13792537
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:13792537
G Matk megakaryocyte-associated tyrosine kinase JBrowse link 7 11,325,246 11,334,311 RGD:13792537
G Melk maternal embryonic leucine zipper kinase JBrowse link 5 59,783,835 59,844,356 RGD:1624291
RGD:13792537
G Peak1 pseudopodium-enriched atypical kinase 1 JBrowse link 8 60,861,742 61,080,128 RGD:1624291
RGD:1600115
G Pkdcc protein kinase domain containing, cytoplasmic JBrowse link 6 6,427,657 6,436,974 RGD:1624291
RGD:1600115
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:1600115
RGD:13792537
RGD:1624291
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1624291
RGD:13792537
RGD:1600115
G Ptk6 protein tyrosine kinase 6 JBrowse link 3 176,698,305 176,706,896 RGD:1624291
RGD:13792537
G Sla src-like adaptor JBrowse link 7 107,585,055 107,604,950 RGD:13792537
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:13792537
G Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites JBrowse link 3 176,709,742 176,716,146 RGD:13792537
G Stk16 serine/threonine kinase 16 JBrowse link 9 82,411,010 82,414,249 RGD:1600115
G Styk1 serine/threonine/tyrosine kinase 1 JBrowse link 4 165,528,027 165,543,365 RGD:13792537
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
G Tec tec protein tyrosine kinase JBrowse link 14 37,918,884 38,027,953 RGD:1624291
RGD:13792537
G Tnk1 tyrosine kinase, non-receptor, 1 JBrowse link 10 56,458,650 56,475,183 RGD:1624291
RGD:13792537
G Tnk2 tyrosine kinase, non-receptor, 2 JBrowse link 11 71,348,726 71,388,520 RGD:13792537
G Txk TXK tyrosine kinase JBrowse link 14 38,029,809 38,085,822 RGD:13792537
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:1600115
G Wee1 WEE1 G2 checkpoint kinase JBrowse link 1 174,765,228 174,790,882 RGD:1600115
G Wee2 WEE1 homolog 2 JBrowse link 4 68,604,770 68,631,341 RGD:1600115
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase JBrowse link 9 121,802,471 121,918,906 RGD:1600115
RGD:13792537
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1600115
histone kinase activity (H3-Y41 specific) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1624291
RGD:1600115
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18265
    catalytic activity 5790
      catalytic activity, acting on a protein 2204
        protein kinase activity 610
          protein tyrosine kinase activity 129
            non-membrane spanning protein tyrosine kinase activity 43
              histone tyrosine kinase activity + 1
Path 2
Term Annotations click to browse term
  molecular_function 18265
    catalytic activity 5790
      transferase activity 2294
        transferase activity, transferring phosphorus-containing groups 960
          kinase activity 810
            protein kinase activity 610
              protein tyrosine kinase activity 129
                non-membrane spanning protein tyrosine kinase activity 43
                  histone tyrosine kinase activity + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.