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ONTOLOGY REPORT - ANNOTATIONS


Term:protein serine/threonine phosphatase activity
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Accession:GO:0004722 term browser browse the term
Definition:Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
Synonyms:exact_synonym: serine/threonine specific protein phosphatase activity
 narrow_synonym: 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase;   Aspergillus awamori acid protein phosphatase;   BCKDH phosphatase;   HMG-CoA reductase phosphatase;   branched-chain alpha-keto acid dehydrogenase phosphatase;   calcineurin;   casein phosphatase;   phosphatase 2A;   phosphatase 2B;   phosphatase C-II;   phosphatase H-II;   phosphatase I;   phosphatase IB;   phosphatase II;   phosphatase III;   phosphatase IV;   phosphatase SP;   phosphopyruvate dehydrogenase phosphatase;   phosphospectrin phosphatase;   polycation modulated (PCM-) phosphatase;   protein D phosphatase;   protein phosphatase X;   protein phosphatase type 1 activity;   protein phosphatase type 1, intrinsic catalyst activity;   protein phosphatase type 2A activity;   protein phosphatase type 2A, intrinsic catalyst activity;   protein phosphatase type 2B activity;   protein phosphatase type 2B, intrinsic catalyst activity;   protein phosphatase type 2C activity;   protein phosphatase type 4 activity;   protein phosphatase type 4, intrinsic catalyst activity
 alt_id: GO:0000158;   GO:0000163;   GO:0008598;   GO:0008600;   GO:0015071;   GO:0030357;   GO:0030358;   GO:0030360;   GO:0030361
 xref: reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2";   reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate";   reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin";   reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT";   reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A";   reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34";   reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A";   reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3";   reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3";   reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1";   reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1";   reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex";   reactome:R-HSA-380949 "AMPK is dephosphorylated";   reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1";   reactome:R-HSA-429730 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate";   reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN";   reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1";   reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs";   reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1";   reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338";   reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P";   reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1";   reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2";   reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6";   reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH";   reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24";   reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2";   reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma";   reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine";   reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO";   reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5";   reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4";   reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII";   reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1"


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protein serine/threonine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc14a cell division cycle 14A JBrowse link 2 219,302,577 219,458,345 RGD:13792537
G Cdc14b cell division cycle 14B JBrowse link 17 1,709,703 1,797,732 RGD:1624291
RGD:13792537
G Cdkn3 cyclin-dependent kinase inhibitor 3 JBrowse link 15 23,553,171 23,564,538 RGD:1624291
RGD:1600115
G Ctdnep1 CTD nuclear envelope phosphatase 1 JBrowse link 10 56,590,822 56,600,235 RGD:1624291
RGD:1600115
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:1600115
RGD:1624291
G Epm2a EPM2A glucan phosphatase, laforin JBrowse link 1 5,448,958 5,571,512 RGD:1624291
RGD:1600115
G Ilkap ILK associated serine/threonine phosphatase JBrowse link 9 98,514,599 98,536,586 RGD:632254
RGD:13792537
RGD:1600115
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:1624291
RGD:1600115
G LOC103694903 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform RGD:13464259
G Mtmr3 myotubularin related protein 3 JBrowse link 14 84,701,559 84,820,487 RGD:1600115
RGD:1624291
G Mtmr4 myotubularin related protein 4 JBrowse link 10 74,886,600 74,909,532 RGD:1600115
G Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 JBrowse link 5 25,577,593 25,584,325 RGD:1642641
RGD:13792537
RGD:1624291
RGD:1600115
G Pdp2 pyruvate dehyrogenase phosphatase catalytic subunit 2 JBrowse link 19 597,427 601,556 RGD:7794756
RGD:13792537
RGD:1600115
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase JBrowse link 12 52,467,417 52,474,533 RGD:1600115
RGD:1624291
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:5131540
RGD:13792537
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 JBrowse link 19 41,731,845 41,798,451 RGD:5131540
G Pp2d1 protein phosphatase 2C-like domain containing 1 JBrowse link 14 72,948,241 72,970,335 RGD:13792537
G Ppa2 inorganic pyrophosphatase 2 JBrowse link 2 238,528,978 238,606,903 RGD:1624291
RGD:1600115
G Ppef1 protein phosphatase with EF-hand domain 1 JBrowse link X 35,822,687 35,947,690 RGD:13792537
G Ppef2 protein phosphatase with EF-hand domain 2 JBrowse link 14 17,306,825 17,333,588 RGD:13792537
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:1624291
RGD:13792537
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:1600115
RGD:13792537
RGD:1624291
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:1624291
RGD:13792537
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E JBrowse link 10 74,548,270 74,679,858 RGD:1299619
RGD:13792537
RGD:1600115
RGD:1624291
RGD:8553885
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F JBrowse link 11 88,313,709 88,343,726 RGD:7241145
RGD:13792537
RGD:1600115
RGD:1624291
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G JBrowse link 6 26,517,840 26,537,292 RGD:1600115
RGD:13792537
RGD:1624291
G Ppm1h protein phosphatase, Mg2+/Mn2+ dependent, 1H JBrowse link 7 66,845,692 67,116,979 RGD:1600115
RGD:13792537
G Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J JBrowse link 2 207,263,307 207,268,601 RGD:1624291
RGD:13792537
RGD:1600115
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K JBrowse link 4 88,694,395 88,721,374 RGD:13792537
G Ppm1l protein phosphatase, Mg2+/Mn2+ dependent, 1L JBrowse link 2 165,932,240 166,218,774 RGD:1624291
RGD:13792537
G Ppm1m protein phosphatase, Mg2+/Mn2+ dependent, 1M JBrowse link 8 114,887,894 114,893,773 RGD:13792537
G Ppm1n protein phosphatase, Mg2+/Mn2+ dependent 1N JBrowse link 1 80,190,293 80,193,002 RGD:13792537
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:1624291
RGD:13792537
G Ppp1cb protein phosphatase 1 catalytic subunit beta JBrowse link 6 23,548,507 23,581,136 RGD:1624291
RGD:13792537
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:1600115
RGD:13792537
RGD:1624291
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:729444
RGD:1624291
RGD:13464259
RGD:8693423
RGD:1582610
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:729591
RGD:13464259
RGD:1582610
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:1624291
RGD:13792537
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta JBrowse link 8 55,279,278 55,311,768 RGD:13792537
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:13792537
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta JBrowse link 18 36,985,709 37,421,383 RGD:13792537
G Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma JBrowse link 14 78,679,214 78,763,175 RGD:13792537
G Ppp2r2d protein phosphatase 2, regulatory subunit B, delta JBrowse link 1 211,205,903 211,240,216 RGD:13792537
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:729536
RGD:1624291
RGD:1600115
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1600115
RGD:1624291
G Ppp4c protein phosphatase 4, catalytic subunit JBrowse link 1 198,219,012 198,225,775 RGD:1600115
RGD:1624291
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 JBrowse link 9 113,515,312 113,573,308 RGD:13792537
G Ppp5c protein phosphatase 5, catalytic subunit JBrowse link 1 78,944,054 78,968,361 RGD:13507298
RGD:13792537
G Ppp6c protein phosphatase 6, catalytic subunit JBrowse link 3 23,478,123 23,510,959 RGD:68293
RGD:1624291
G Pptc7 protein phosphatase targeting COQ7 JBrowse link 12 39,731,107 39,769,480 RGD:1600115
RGD:1624291
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
RGD:1600115
G Rpap2 RNA polymerase II associated protein 2 JBrowse link 14 3,125,595 3,204,590 RGD:1624291
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:13792537
G Timm50 translocase of inner mitochondrial membrane 50 JBrowse link 1 85,470,810 85,480,813 RGD:1624291
RGD:1600115
G Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 JBrowse link 10 30,103,607 30,118,945 RGD:1624291
RGD:13792537
RGD:1600115
calcium-dependent protein serine/threonine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppp2r3b protein phosphatase 2, regulatory subunit B'', beta JBrowse link 14 1,469,748 1,476,353 RGD:1624291
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:729536
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:729536
calmodulin-dependent protein phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:1600115
RGD:1624291
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F JBrowse link 11 88,313,709 88,343,726 RGD:1600115
RGD:1624291
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:1600115
RGD:13792537
RGD:1624291
RGD:13507300
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1600115
RGD:13792537
RGD:1624291
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:1624291
RGD:13792537
magnesium-dependent protein serine/threonine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ilkap ILK associated serine/threonine phosphatase JBrowse link 9 98,514,599 98,536,586 RGD:13792537
G Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 JBrowse link 5 25,577,593 25,584,325 RGD:1582364
RGD:13792537
RGD:729524
G Pdp2 pyruvate dehyrogenase phosphatase catalytic subunit 2 JBrowse link 19 597,427 601,556 RGD:1582364
RGD:13792537
RGD:729524
G Pp2d1 protein phosphatase 2C-like domain containing 1 JBrowse link 14 72,948,241 72,970,335 RGD:13792537
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:13792537
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:13792537
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:13792537
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E JBrowse link 10 74,548,270 74,679,858 RGD:13792537
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F JBrowse link 11 88,313,709 88,343,726 RGD:13792537
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G JBrowse link 6 26,517,840 26,537,292 RGD:13792537
G Ppm1h protein phosphatase, Mg2+/Mn2+ dependent, 1H JBrowse link 7 66,845,692 67,116,979 RGD:13792537
G Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J JBrowse link 2 207,263,307 207,268,601 RGD:13792537
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K JBrowse link 4 88,694,395 88,721,374 RGD:13792537
G Ppm1l protein phosphatase, Mg2+/Mn2+ dependent, 1L JBrowse link 2 165,932,240 166,218,774 RGD:13792537
G Ppm1m protein phosphatase, Mg2+/Mn2+ dependent, 1M JBrowse link 8 114,887,894 114,893,773 RGD:13792537
G Ppm1n protein phosphatase, Mg2+/Mn2+ dependent 1N JBrowse link 1 80,190,293 80,193,002 RGD:13792537
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:13792537
MAP kinase serine/threonine phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:1600115
RGD:1624291
G Pp2d1 protein phosphatase 2C-like domain containing 1 JBrowse link 14 72,948,241 72,970,335 RGD:13792537
myosin phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppp1cb protein phosphatase 1 catalytic subunit beta JBrowse link 6 23,548,507 23,581,136 RGD:1600115
RNA polymerase II CTD heptapeptide repeat phosphatase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctdp1 CTD phosphatase subunit 1 JBrowse link 18 76,922,913 76,985,095 RGD:1624291
RGD:13792537
G Ctdsp1 CTD small phosphatase 1 JBrowse link 9 81,672,613 81,677,979 RGD:1624291
RGD:13792537
G Ctdsp2 CTD small phosphatase 2 JBrowse link 7 70,283,683 70,291,795 RGD:1624291
RGD:1600115
G Ctdspl CTD small phosphatase like JBrowse link 8 127,065,292 127,726,248 RGD:13792537
G Ctdspl2 CTD small phosphatase like 2 JBrowse link 3 113,906,803 113,957,289 RGD:1600115
RGD:1624291
G Rpap2 RNA polymerase II associated protein 2 JBrowse link 14 3,125,595 3,204,590 RGD:1624291
RGD:13792537
RGD:1600115
G Ssu72 SSU72 homolog, RNA polymerase II CTD phosphatase JBrowse link 5 173,152,964 173,182,720 RGD:1624291
RGD:13792537
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19490
    catalytic activity 6049
      catalytic activity, acting on a protein 2288
        phosphoprotein phosphatase activity 177
          protein serine/threonine phosphatase activity 64
            MAP kinase serine/threonine phosphatase activity 2
            RNA polymerase II CTD heptapeptide repeat phosphatase activity 7
            calcium-dependent protein serine/threonine phosphatase activity + 6
            magnesium-dependent protein serine/threonine phosphatase activity 17
            myosin phosphatase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 19490
    catalytic activity 6049
      hydrolase activity 2605
        hydrolase activity, acting on ester bonds 782
          phosphoric ester hydrolase activity 375
            phosphatase activity 279
              phosphoprotein phosphatase activity 177
                protein serine/threonine phosphatase activity 64
                  MAP kinase serine/threonine phosphatase activity 2
                  RNA polymerase II CTD heptapeptide repeat phosphatase activity 7
                  calcium-dependent protein serine/threonine phosphatase activity + 6
                  magnesium-dependent protein serine/threonine phosphatase activity 17
                  myosin phosphatase activity 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.