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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingomyelin phosphodiesterase activity
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Accession:GO:0004767 term browser browse the term
Definition:Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+).
Synonyms:exact_synonym: sphingomyelin cholinephosphohydrolase activity;   sphingomyelinase activity
 alt_id: GO:0030230;   GO:0030231
 xref: EC:3.1.4.12;   KEGG_REACTION:R02541;   MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN;   RHEA:19253;   reactome:R-HSA-1605797 "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)";   reactome:R-HSA-1606273 "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)";   reactome:R-HSA-1606288 "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)";   reactome:R-HSA-1640164 "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin";   reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets"


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sphingomyelin phosphodiesterase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 JBrowse link 10 108,095,131 108,099,483 RGD:1600115
RGD:1624291
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:13792537
G Smpd2 sphingomyelin phosphodiesterase 2 JBrowse link 20 46,212,070 46,215,183 RGD:634108
RGD:13792537
RGD:1624291
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1624291
RGD:13792537
G Smpd5 sphingomyelin phosphodiesterase 5 JBrowse link 7 117,351,694 117,354,241 RGD:1624291
RGD:13792537
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A JBrowse link 20 40,779,022 40,800,842 RGD:1624291
RGD:1600115
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B JBrowse link 5 150,925,150 150,946,994 RGD:1600115
acid sphingomyelin phosphodiesterase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:1624291
RGD:13792537
neutral sphingomyelin phosphodiesterase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:1600115
RGD:1624291

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Term Annotations click to browse term
  molecular_function 19527
    catalytic activity 6039
      hydrolase activity 2608
        hydrolase activity, acting on ester bonds 781
          phosphoric ester hydrolase activity 369
            phosphoric diester hydrolase activity 92
              sphingomyelin phosphodiesterase activity 7
                acid sphingomyelin phosphodiesterase activity 1
                neutral sphingomyelin phosphodiesterase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.