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ONTOLOGY REPORT - ANNOTATIONS


Term:triglyceride lipase activity
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Accession:GO:0004806 term browser browse the term
Definition:Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
Synonyms:exact_synonym: TAG activity;   butyrinase activity;   cacordase activity;   glycerol ester hydrolase activity;   triacetinase activity;   triacylglycerol acylhydrolase activity;   triacylglycerol ester hydrolase activity;   triacylglycerol lipase activity;   tributyrin esterase activity;   tributyrinase activity;   triglyceridase activity;   triglyceride hydrolase activity;   triolein hydrolase activity;   tween hydrolase activity;   tween-hydrolyzing esterase activity;   tweenase activity;   tweenesterase activity
 narrow_synonym: heparin releasable hepatic lipase;   hepatic lipase;   hepatic monoacylglycerol acyltransferase;   liver lipase;   post-heparin plasma protamine-resistant lipase;   salt-resistant post-heparin lipase
 related_synonym: GA 56;   GEH;   PPL;   amano AP;   amano B;   amano CE;   amano CES;   amano P;   amno N-AP;   capalase L;   lipazin;   meito MY 30;   meito sangyo OF lipase;   steapsin;   takedo 1969-4-9;   tributyrase activity
 xref: EC:3.1.1.3;   MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN;   RHEA:12044;   reactome:R-HSA-1482777 "TAG is hydrolyzed to DAG by PNPLA2/3";   reactome:R-HSA-163551 "triacylglycerol + H2O -> diacylglycerol + fatty acid";   reactome:R-HSA-5694109 "LIPC dimer hydrolyses TAG to DAG and FA";   reactome:R-HSA-8848338 "PNPLA4 hydrolyzes TAG";   reactome:R-HSA-8848339 "PNPLA5 hydrolyzes TAG"


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triglyceride lipase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aadac arylacetamide deacetylase JBrowse link 2 150,146,234 150,157,480 RGD:1600115
RGD:13792537
RGD:1624291
G Abhd5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase JBrowse link 8 130,973,222 131,001,448 RGD:1624291
RGD:1600115
G Cel carboxyl ester lipase JBrowse link 3 7,134,021 7,141,522 RGD:2313555
RGD:13792537
G Ces1a carboxylesterase 1A JBrowse link 19 15,339,152 15,366,079 RGD:13792537
G Ces1c carboxylesterase 1C JBrowse link 19 15,294,524 15,335,005 RGD:13792537
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:1600115
RGD:13792537
RGD:1624291
G Ces1e carboxylesterase 1E RGD:13792537
G Ces1f carboxylesterase 1F JBrowse link 19 15,081,117 15,126,629 RGD:13792537
G Ces4a carboxylesterase 4A JBrowse link 19 37,090,018 37,111,448 RGD:13792537
G Ces5a carboxylesterase 5A JBrowse link 19 12,097,529 12,136,579 RGD:13792537
G Cesl1 carboxylesterase-like 1 RGD:13792537
G Ddhd2 DDHD domain containing 2 JBrowse link 16 71,090,096 71,120,713 RGD:1624291
RGD:13792537
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:1580511
RGD:1624291
RGD:1600115
RGD:1600640
RGD:1600649
G Lipe lipase E, hormone sensitive type JBrowse link 1 82,248,031 82,266,727 RGD:1624291
G Lipf lipase F, gastric type JBrowse link 1 252,284,464 252,302,811 RGD:1600115
G LOC100911615 patatin-like phospholipase domain-containing protein 2-like JBrowse link 1 213,997,721 214,002,811 RGD:1600115
RGD:13792537
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:1624291
G Pnlip pancreatic lipase JBrowse link 1 279,798,187 279,811,372 RGD:2303166
RGD:13792537
RGD:1624291
RGD:1600115
G Pnliprp1 pancreatic lipase-related protein 1 JBrowse link 1 279,867,034 279,882,663 RGD:1600115
G Pnliprp2 pancreatic lipase related protein 2 JBrowse link 1 279,896,973 279,927,600 RGD:2303166
RGD:13792537
RGD:1624291
RGD:1600115
G Pnpla1 patatin-like phospholipase domain containing 1 JBrowse link 20 6,101,061 6,143,762 RGD:13792537
G Pnpla2 patatin-like phospholipase domain containing 2 JBrowse link 1 214,434,638 214,439,720 RGD:1624291
RGD:13792537
RGD:1600115
G Pnpla3 patatin-like phospholipase domain containing 3 JBrowse link 7 125,034,760 125,056,165 RGD:1624291
RGD:13792537
G Pnpla4 patatin like phospholipase domain containing 4 JBrowse link X 45,519,406 45,522,988 RGD:1624291
RGD:13792537
G Pnpla5 patatin-like phospholipase domain containing 5 JBrowse link 7 124,988,524 124,999,137 RGD:1624291
RGD:13792537
lipoprotein lipase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lipg lipase G, endothelial type JBrowse link 18 70,903,528 70,924,434 RGD:1600115
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:70246
RGD:1624291
RGD:10047183
RGD:1580532

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  molecular_function 19527
    catalytic activity 6039
      hydrolase activity 2608
        hydrolase activity, acting on ester bonds 781
          carboxylic ester hydrolase activity 156
            triglyceride lipase activity 26
              lipoprotein lipase activity 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.