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Term:tryptophan 2,3-dioxygenase activity
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Accession:GO:0004833 term browser browse the term
Definition:Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
Synonyms:exact_synonym: L-tryptophan 2,3-dioxygenase activity;   L-tryptophan pyrrolase activity;   L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing);   indoleamine-pyrrole 2,3-dioxygenase activity;   tryptamin 2,3-dioxygenase activity;   tryptamine 2,3-dioxygenase activity
 broad_synonym: indolamine 2,3-dioxygenase activity;   tryptophan oxygenase activity;   tryptophan peroxidase activity;   tryptophan pyrrolase activity
 related_synonym: TDO
 alt_id: GO:0004426
 xref: EC:;   MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN;   RHEA:24536;   reactome:R-HSA-198563 "IDO1 dioxygenates L-Trp to NFK";   reactome:R-HSA-71188 "TDO tetramer dioxygenates L-Trp to NFK";   reactome:R-HSA-888614 "IDO2 dioxygenates L-Trp to NFK"

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tryptophan 2,3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IDO1 indoleamine 2,3-dioxygenase 1 JBrowse link 8 36,606,721 36,632,371 RGD:9068941
G IDO2 indoleamine 2,3-dioxygenase 2 JBrowse link 8 36,657,311 36,717,606 RGD:9068941
G TDO2 tryptophan 2,3-dioxygenase JBrowse link 4 160,085,840 160,102,266 RGD:9068941

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  molecular_function 15784
    catalytic activity 5429
      oxidoreductase activity 692
        dioxygenase activity 88
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 26
            tryptophan 2,3-dioxygenase activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.