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Term:tryptophan 2,3-dioxygenase activity
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Accession:GO:0004833 term browser browse the term
Definition:Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
Synonyms:exact_synonym: L-tryptophan 2,3-dioxygenase activity;   L-tryptophan pyrrolase activity;   L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing);   indoleamine-pyrrole 2,3-dioxygenase activity;   tryptamin 2,3-dioxygenase activity;   tryptamine 2,3-dioxygenase activity
 broad_synonym: indolamine 2,3-dioxygenase activity;   tryptophan oxygenase activity;   tryptophan peroxidase activity;   tryptophan pyrrolase activity
 related_synonym: TDO
 alt_id: GO:0004426
 xref: EC:;   MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN;   RHEA:24536;   reactome:R-HSA-198563 "IDO1 dioxygenates L-Trp to NFK";   reactome:R-HSA-71188 "TDO tetramer dioxygenates L-Trp to NFK";   reactome:R-HSA-888614 "IDO2 dioxygenates L-Trp to NFK"

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tryptophan 2,3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ido1 indoleamine 2,3-dioxygenase 1 JBrowse link NW_004955536 2,944,770 2,955,829 RGD:9068941
G Ido2 indoleamine 2,3-dioxygenase 2 JBrowse link NW_004955536 2,894,410 2,938,862 RGD:9068941
G Tdo2 tryptophan 2,3-dioxygenase JBrowse link NW_004955471 11,229,795 11,245,255 RGD:9068941

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  molecular_function 14651
    catalytic activity 5205
      oxidoreductase activity 641
        dioxygenase activity 88
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 26
            tryptophan 2,3-dioxygenase activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.