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ONTOLOGY REPORT - ANNOTATIONS


Term:tryptophan 2,3-dioxygenase activity
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Accession:GO:0004833 term browser browse the term
Definition:Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
Synonyms:exact_synonym: L-tryptophan 2,3-dioxygenase activity;   L-tryptophan pyrrolase activity;   L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing);   indoleamine-pyrrole 2,3-dioxygenase activity;   tryptamin 2,3-dioxygenase activity;   tryptamine 2,3-dioxygenase activity
 broad_synonym: indolamine 2,3-dioxygenase activity;   tryptophan oxygenase activity;   tryptophan peroxidase activity;   tryptophan pyrrolase activity
 related_synonym: TDO
 alt_id: GO:0004426
 xref: EC:1.13.11.11;   MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN;   RHEA:24536;   reactome:R-HSA-198563 "IDO1 dioxygenates L-Trp to NFK";   reactome:R-HSA-71188 "TDO tetramer dioxygenates L-Trp to NFK";   reactome:R-HSA-888614 "IDO2 dioxygenates L-Trp to NFK"


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tryptophan 2,3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ido1 indoleamine 2,3-dioxygenase 1 JBrowse link 16 72,216,326 72,228,098 RGD:1624291
RGD:13792537
RGD:1600115
G Ido2 indoleamine 2,3-dioxygenase 2 JBrowse link 16 72,232,852 72,291,227 RGD:13792537
G Tdo2 tryptophan 2,3-dioxygenase JBrowse link 2 180,897,059 180,914,919 RGD:2290190
RGD:13792537
RGD:1624291
RGD:2290313
RGD:2291804
RGD:2303721

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  molecular_function 19528
    catalytic activity 6039
      oxidoreductase activity 845
        dioxygenase activity 79
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 27
            tryptophan 2,3-dioxygenase activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.