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ONTOLOGY REPORT - ANNOTATIONS


Term:tubulin-tyrosine ligase activity
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Accession:GO:0004835 term browser browse the term
Definition:Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
Synonyms:exact_synonym: TTL activity;   alpha-tubulin:L-tyrosine ligase (ADP-forming);   tubulinyl-tyrosine ligase activity
 xref: EC:6.3.2.25;   MetaCyc:6.3.2.25-RXN;   RHEA:17605;   reactome:R-HSA-8955706 "TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin"


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tubulin-tyrosine ligase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ttl tubulin tyrosine ligase JBrowse link 3 121,596,773 121,626,581 RGD:634442
RGD:1624291
RGD:1600115
G Ttll12 tubulin tyrosine ligase like 12 JBrowse link 7 124,472,758 124,491,004 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20377
    catalytic activity 6065
      catalytic activity, acting on a protein 2291
        tubulin-tyrosine ligase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 20377
    catalytic activity 6065
      ligase activity 182
        ligase activity, forming carbon-nitrogen bonds 53
          acid-amino acid ligase activity 25
            tubulin-tyrosine ligase activity 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.