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Term:uroporphyrinogen-III synthase activity
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Accession:GO:0004852 term browser browse the term
Definition:Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III.
Synonyms:related_synonym: URO-synthase activity;   hydroxymethylbilane hydro-lyase (cyclizing) activity;   hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming);   porphobilinogenase activity;   uroporphyrinogen III cosynthase activity;   uroporphyrinogen isomerase activity;   uroporphyrinogen-III cosynthetase activity
 xref: EC:;   KEGG_REACTION:R03165;   MetaCyc:UROGENIIISYN-RXN;   RHEA:18965;   reactome:R-HSA-189488 "UROS transforms HMB to URO3"

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uroporphyrinogen-III synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase IDA in the presence of tetrahydropteroylglutamate RGD PMID:6466301 RGD:2303402 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
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G Uros uroporphyrinogen III synthase contributes_to IDA
(PMID:18004775), (PMID:3174619), (PMID:3805019)
MGI:3620007 (MGI:72967|PMID:7607680)
RGD PMID:3174619, PMID:3805019, PMID:7607680, PMID:18004775, PMID:6604545 MGI:3620006, MGI:72967, RGD:2303403 NCBI chr 1:205,755,766...205,778,170
Ensembl chr 1:205,756,640...205,777,167
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  molecular_function 20471
    catalytic activity 6068
      lyase activity 212
        carbon-oxygen lyase activity 92
          hydro-lyase activity 71
            uroporphyrinogen-III synthase activity 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.