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Term:transmembrane signaling receptor activity
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Accession:GO:0004888 term browser browse the term
Definition:Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Comment:This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
Synonyms:exact_synonym: transmembrane signalling receptor activity
 broad_synonym: transmembrane receptor activity
 alt_id: GO:0004926;   GO:0099600
 xref: reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex"

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  molecular_function 20377
    molecular transducer activity 2669
      signaling receptor activity 2669
        transmembrane signaling receptor activity 2499
          G protein-coupled receptor activity + 2026
          GABA receptor activity + 22
          ICAM-3 receptor activity 2
          MHC class I receptor activity + 4
          MHC class II receptor activity 1
          MHC class Ib receptor activity + 2
          Wnt-activated receptor activity 17
          acetylcholine receptor activity + 18
          apolipoprotein A-I receptor activity 2
          axon guidance receptor activity 9
          collagen receptor activity + 7
          complement receptor activity + 12
          cytokine receptor activity + 97
          cytokinin receptor activity + 0
          death receptor activity + 8
          glutamate receptor activity + 31
          hedgehog receptor activity 4
          immunoglobulin receptor activity + 10
          latrotoxin receptor activity 1
          netrin receptor activity + 6
          neuregulin receptor activity 2
          neurotensin receptor activity, non-G protein-coupled 1
          non-tyrosine kinase fibroblast growth factor receptor activity 0
          nucleotide receptor activity + 21
          olfactory receptor activity + 1482
          opsonin receptor activity + 3
          osmosensor activity + 5
          reelin receptor activity 2
          semaphorin receptor activity 13
          serotonin receptor activity + 42
          sulfonylurea receptor activity 4
          taste receptor activity + 41
          tiggrin receptor activity 0
          transmembrane receptor protein kinase activity + 83
          transmembrane receptor protein phosphatase activity + 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.