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Term:transmembrane signaling receptor activity
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Accession:GO:0004888 term browser browse the term
Definition:Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Comment:This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
Synonyms:exact_synonym: transmembrane signalling receptor activity
 broad_synonym: transmembrane receptor activity
 alt_id: GO:0004926;   GO:0099600
 xref: reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex"

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  molecular_function 138873
    molecular transducer activity 11740
      signaling receptor activity 11740
        transmembrane signaling receptor activity 10579
          G protein-coupled receptor activity + 6804
          GABA receptor activity + 161
          ICAM-3 receptor activity 17
          MHC class I receptor activity + 33
          MHC class II receptor activity 13
          MHC class Ib receptor activity + 16
          Wnt-activated receptor activity 125
          acetylcholine receptor activity + 139
          apolipoprotein A-I receptor activity 16
          axon guidance receptor activity 70
          collagen receptor activity + 50
          complement receptor activity + 62
          cytokine receptor activity + 675
          cytokinin receptor activity + 0
          death receptor activity + 62
          glutamate receptor activity + 207
          hedgehog receptor activity 19
          immunoglobulin receptor activity + 64
          latrotoxin receptor activity 9
          netrin receptor activity + 42
          neuregulin receptor activity 16
          neurotensin receptor activity, non-G protein-coupled 8
          non-tyrosine kinase fibroblast growth factor receptor activity 1
          nucleotide receptor activity + 137
          olfactory receptor activity + 4787
          opsonin receptor activity + 27
          osmosensor activity + 39
          reelin receptor activity 16
          semaphorin receptor activity 92
          serotonin receptor activity + 216
          sulfonylurea receptor activity 14
          taste receptor activity + 200
          tiggrin receptor activity 0
          transmembrane receptor protein kinase activity + 565
          transmembrane receptor protein phosphatase activity + 51
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.