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ONTOLOGY REPORT - ANNOTATIONS


Term:extracellularly ATP-gated cation channel activity
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Accession:GO:0004931 term browser browse the term
Definition:Enables the transmembrane transfer of a cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Comment:Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'.
Synonyms:broad_synonym: purinoceptor;   purinoreceptor
 related_synonym: P2X receptor
 xref: reactome:R-HSA-877187 "P2X7 mediates loss of intracellular K+"


show annotations for term's descendants       view all columns           Sort by:
 
extracellularly ATP-gated cation channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G P2rx1 purinergic receptor P2X 1 JBrowse link 10 59,566,268 59,581,328 RGD:1642659
RGD:13792537
RGD:1600115
RGD:727431
G P2rx2 purinergic receptor P2X 2 JBrowse link 12 52,397,666 52,401,005 RGD:1642653
RGD:1600115
RGD:13792537
RGD:1624291
RGD:1642666
RGD:1642665
RGD:1642661
RGD:1642659
G P2rx3 purinergic receptor P2X 3 JBrowse link 3 72,403,992 72,447,801 RGD:1642659
RGD:1600115
RGD:13792537
RGD:1624291
RGD:729168
RGD:1642675
G P2rx4 purinergic receptor P2X 4 JBrowse link 12 39,308,022 39,325,673 RGD:1642659
RGD:13792537
RGD:61682
RGD:1624291
RGD:1642695
RGD:1642691
G P2rx5 purinergic receptor P2X 5 JBrowse link 10 59,725,438 59,737,126 RGD:729229
RGD:727431
RGD:1624291
RGD:13792537
RGD:1600115
G P2rx6 purinergic receptor P2X 6 JBrowse link 11 87,434,929 87,445,221 RGD:729425
RGD:13792537
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:628349
RGD:1600115
RGD:13792537
RGD:1624291
RGD:69918
RGD:1642698

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18245
    transporter activity 1178
      transmembrane transporter activity 1047
        ion transmembrane transporter activity 863
          ion gated channel activity 332
            ATP-gated ion channel activity 8
              extracellularly ATP-gated cation channel activity 7
Path 2
Term Annotations click to browse term
  molecular_function 18245
    transporter activity 1178
      transmembrane transporter activity 1047
        passive transmembrane transporter activity 461
          channel activity 461
            gated channel activity 344
              ion gated channel activity 332
                ligand-gated ion channel activity 135
                  extracellular ligand-gated ion channel activity 70
                    excitatory extracellular ligand-gated ion channel activity 35
                      extracellularly ATP-gated cation channel activity 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.