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ONTOLOGY REPORT - ANNOTATIONS


Term:ARF guanyl-nucleotide exchange factor activity
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Accession:GO:0005086 term browser browse the term
Definition:Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
Synonyms:xref: reactome:R-HSA-350769 "trans-Golgi Network Coat Activation";   reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4";   reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF";   reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane"


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ARF guanyl-nucleotide exchange factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 JBrowse link 5 8,666,046 8,760,458 RGD:1600115
G Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 JBrowse link 3 163,570,435 163,656,612 RGD:1624291
RGD:1600115
G Arfgef3 ARFGEF family member 3 JBrowse link 1 13,837,861 13,918,277 RGD:1600115
G Cyth1 cytohesin 1 JBrowse link 10 107,197,983 107,281,285 RGD:1624291
RGD:1600115
G Cyth2 cytohesin 2 JBrowse link 1 101,796,349 101,803,407 RGD:1600115
RGD:1624291
G Cyth3 cytohesin 3 JBrowse link 12 12,877,559 12,907,771 RGD:1600115
RGD:1624291
G Cyth4 cytohesin 4 JBrowse link 7 119,820,521 119,845,003 RGD:1624291
G Fbxo8 F-box protein 8 JBrowse link 16 37,131,566 37,177,033 RGD:1600115
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 JBrowse link 1 265,904,616 266,033,107 RGD:1600115
G Iqsec1 IQ motif and Sec7 domain ArfGEF 1 JBrowse link 4 123,400,717 123,454,656 RGD:1600115
G Iqsec2 IQ motif and Sec7 domain ArfGEF 2 JBrowse link X 22,212,137 22,293,810 RGD:1624291
G Iqsec3 IQ motif and Sec7 domain ArfGEF 3 JBrowse link 4 153,948,052 154,044,493 RGD:1600115
G Preb prolactin regulatory element binding JBrowse link 6 26,784,088 26,787,875 RGD:1624291
G Psd pleckstrin and Sec7 domain containing JBrowse link 1 266,059,331 266,074,774 RGD:1624291
RGD:1600115
G Psd2 pleckstrin and Sec7 domain containing 2 JBrowse link 18 28,781,267 28,832,429 RGD:1600115
G Psd3 pleckstrin and Sec7 domain containing 3 JBrowse link 16 23,212,165 23,789,414 RGD:1624291
RGD:13792537
G Psd4 pleckstrin and Sec7 domain containing 4 JBrowse link 3 1,478,432 1,515,094 RGD:1600115
G Sec61b SEC61 translocon subunit beta JBrowse link 5 63,192,322 63,200,532 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20216
    molecular function regulator 3204
      guanyl-nucleotide exchange factor activity 227
        ARF guanyl-nucleotide exchange factor activity 18
Path 2
Term Annotations click to browse term
  molecular_function 20216
    binding 16745
      protein binding 14229
        enzyme binding 2449
          GTPase binding 558
            guanyl-nucleotide exchange factor activity 227
              ARF guanyl-nucleotide exchange factor activity 18
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.