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ONTOLOGY REPORT - ANNOTATIONS


Term:ARF guanyl-nucleotide exchange factor activity
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Accession:GO:0005086 term browser browse the term
Definition:Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
Synonyms:xref: reactome:R-HSA-350769 "trans-Golgi Network Coat Activation";   reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4";   reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF";   reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane"


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ARF guanyl-nucleotide exchange factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARFGEF1 ADP ribosylation factor guanine nucleotide exchange factor 1 JBrowse link 4 67,465,517 67,613,611 RGD:14298760
G ARFGEF2 ADP ribosylation factor guanine nucleotide exchange factor 2 JBrowse link 17 50,631,844 50,732,253 RGD:14298760
G ARFGEF3 ARFGEF family member 3 JBrowse link 1 26,069,337 26,256,871 RGD:14298760
G CYTH1 cytohesin 1 JBrowse link 12 3,356,265 3,432,644 RGD:14298760
G CYTH2 cytohesin 2 JBrowse link 6 53,869,475 53,878,856 RGD:14298760
G CYTH3 cytohesin 3 JBrowse link 3 4,900,575 5,002,201 RGD:14298760
G CYTH4 cytohesin 4 JBrowse link 5 10,491,202 10,521,583 RGD:14298760
G FBXO8 F-box protein 8 JBrowse link 14 15,896,006 15,933,154 RGD:14298760
G GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 JBrowse link 14 113,245,486 113,379,472 RGD:14298760
G IQSEC1 IQ motif and Sec7 domain ArfGEF 1 JBrowse link 13 71,203,967 71,366,685 RGD:14298760
G IQSEC2 IQ motif and Sec7 domain ArfGEF 2 JBrowse link X 46,011,386 46,094,978 RGD:14298760
G IQSEC3 IQ motif and Sec7 domain ArfGEF 3 JBrowse link 5 67,445,839 67,540,488 RGD:14298760
G PREB prolactin regulatory element binding JBrowse link 3 111,992,364 111,996,194 RGD:9068941
G PSD pleckstrin and Sec7 domain containing JBrowse link 14 113,414,697 113,430,093 RGD:14298760
G PSD2 pleckstrin and Sec7 domain containing 2 JBrowse link 2 141,591,724 141,658,711 RGD:14298760
G PSD3 pleckstrin and Sec7 domain containing 3 JBrowse link 17 12,645,743 13,267,176 RGD:14298760
G SEC61B SEC61 translocon subunit beta JBrowse link 1 240,985,173 240,991,820 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17331
    molecular function regulator 2939
      guanyl-nucleotide exchange factor activity 202
        ARF guanyl-nucleotide exchange factor activity 17
Path 2
Term Annotations click to browse term
  molecular_function 17331
    binding 15093
      protein binding 13537
        enzyme binding 2319
          GTPase binding 518
            guanyl-nucleotide exchange factor activity 202
              ARF guanyl-nucleotide exchange factor activity 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.