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ONTOLOGY REPORT - ANNOTATIONS


Term:inhibitory extracellular ligand-gated ion channel activity
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Accession:GO:0005237 term browser browse the term
Definition:Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.


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inhibitory extracellular ligand-gated ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 JBrowse link 10 27,310,718 27,371,802 RGD:728715
RGD:13792537
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 JBrowse link 14 39,662,411 39,801,082 RGD:13792537
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 JBrowse link X 152,414,332 152,642,607 RGD:13792537
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 JBrowse link 14 39,154,072 39,230,994 RGD:13792537
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 JBrowse link 1 112,833,941 112,947,482 RGD:13792537
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 10 27,847,447 27,862,896 RGD:1626493
RGD:13792537
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 JBrowse link 10 27,973,694 28,193,072 RGD:727351
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 152,220,180 152,237,347 RGD:13792537
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 JBrowse link 14 39,964,502 40,051,306 RGD:13792537
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 JBrowse link 10 27,090,913 27,179,786 RGD:728419
RGD:13792537
G Gabrg3 gamma-aminobutyric acid type A receptor subunit gamma 3 JBrowse link 1 112,158,525 112,812,267 RGD:13792537
G Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 JBrowse link 5 48,303,366 48,341,571 RGD:728465
extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Glra1 glycine receptor, alpha 1 JBrowse link 10 40,851,955 40,954,364 RGD:625689
RGD:13792537
RGD:1624291
RGD:8553668
G Glra2 glycine receptor, alpha 2 JBrowse link X 30,612,894 30,832,078 RGD:728718
RGD:13792537
RGD:1600115
RGD:1624291
G Glra3 glycine receptor, alpha 3 JBrowse link 16 37,676,959 37,908,221 RGD:728440
RGD:1600115
RGD:11035333
RGD:1624291
G Glra4 glycine receptor, alpha 4 JBrowse link X 107,416,019 107,447,253 RGD:1624291
RGD:13792537
G Glrb glycine receptor, beta JBrowse link 2 179,768,040 179,842,612 RGD:1624291
RGD:13792537
RGD:8554374

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20377
    transporter activity 1242
      transmembrane transporter activity 1106
        ion transmembrane transporter activity 893
          ion channel activity 442
            ligand-gated ion channel activity 134
              extracellular ligand-gated ion channel activity 70
                inhibitory extracellular ligand-gated ion channel activity 17
                  extracellularly glycine-gated chloride channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 20377
    transporter activity 1242
      transmembrane transporter activity 1106
        passive transmembrane transporter activity 491
          channel activity 491
            gated channel activity 340
              ligand-gated channel activity 137
                ligand-gated ion channel activity 134
                  extracellular ligand-gated ion channel activity 70
                    inhibitory extracellular ligand-gated ion channel activity 17
                      extracellularly glycine-gated chloride channel activity 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.