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ONTOLOGY REPORT - ANNOTATIONS


Term:inhibitory extracellular ligand-gated ion channel activity
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Accession:GO:0005237 term browser browse the term
Definition:Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.


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inhibitory extracellular ligand-gated ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 JBrowse link 4 49,006,981 49,065,205 RGD:13508589
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 JBrowse link 13 42,367,988 42,488,069 RGD:13508589
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 JBrowse link X 120,152,650 120,460,604 RGD:13508589
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 JBrowse link 13 42,889,100 42,958,604 RGD:13508589
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 JBrowse link 3 33,663,414 33,746,120 RGD:13508589
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 4 49,208,691 49,225,754 RGD:13508589
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 JBrowse link 4 49,342,527 49,579,697 RGD:9068941
G GABRE gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 119,913,867 119,937,867 RGD:13508589
G GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 JBrowse link 13 42,194,929 42,276,379 RGD:13508589
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 JBrowse link 4 48,794,770 48,901,859 RGD:13508589
G GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 JBrowse link 3 32,956,061 33,641,971 RGD:13508589
extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLRA1 glycine receptor alpha 1 JBrowse link 4 57,443,094 57,541,494 RGD:9068941
RGD:13508589
G GLRA2 glycine receptor alpha 2 JBrowse link X 10,859,699 11,033,386 RGD:13508589
G GLRA3 glycine receptor alpha 3 JBrowse link 25 25,098,280 25,305,511 RGD:13508589
G GLRA4 glycine receptor alpha 4 (pseudogene) JBrowse link X 77,115,962 77,142,381 RGD:9068941
RGD:13508589
G GLRB glycine receptor beta JBrowse link 15 54,429,131 54,519,844 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16928
    transporter activity 1180
      transmembrane transporter activity 1056
        ion transmembrane transporter activity 867
          ion channel activity 433
            ligand-gated ion channel activity 131
              extracellular ligand-gated ion channel activity 72
                inhibitory extracellular ligand-gated ion channel activity 16
                  extracellularly glycine-gated chloride channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 16928
    transporter activity 1180
      transmembrane transporter activity 1056
        passive transmembrane transporter activity 471
          channel activity 471
            gated channel activity 323
              ligand-gated channel activity 134
                ligand-gated ion channel activity 131
                  extracellular ligand-gated ion channel activity 72
                    inhibitory extracellular ligand-gated ion channel activity 16
                      extracellularly glycine-gated chloride channel activity 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.