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ONTOLOGY REPORT - ANNOTATIONS


Term:chloride channel activity
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Accession:GO:0005254 term browser browse the term
Definition:Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
Synonyms:xref: Reactome:R-HSA-975449 "GABRR pentamers:GABA transports extracellular Cl- to cytosol";   reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region";   reactome:R-HSA-427570 "Group 3 - Selective Cl- transport";   reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol"


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chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC094348.3 RGD:13792537
G Ano1 anoctamin 1 JBrowse link 1 217,754,349 217,902,540 RGD:1624291
RGD:13792537
G Ano2 anoctamin 2 JBrowse link 4 158,222,650 158,577,595 RGD:13792537
G Ano3 anoctamin 3 JBrowse link 3 101,843,516 102,203,368 RGD:13792537
G Ano4 anoctamin 4 JBrowse link 7 29,492,017 30,025,587 RGD:13792537
G Ano5 anoctamin 5 JBrowse link 1 106,873,580 106,971,769 RGD:13792537
G Ano6 anoctamin 6 JBrowse link 7 137,142,063 137,335,208 RGD:13792537
G Ano7 anoctamin 7 JBrowse link 9 100,511,610 100,551,798 RGD:13792537
G Ano9 anoctamin 9 JBrowse link 1 213,908,389 213,929,291 RGD:13792537
G Best1 bestrophin 1 JBrowse link 1 226,033,146 226,049,893 RGD:1624291
G Best2 bestrophin 2 JBrowse link 19 26,122,869 26,129,619 RGD:1624291
G Best3 bestrophin 3 JBrowse link 7 59,971,084 60,057,162 RGD:1624291
G Best4 bestrophin 4 JBrowse link 5 136,013,978 136,017,742 RGD:1600115
G Bsnd barttin CLCNK type accessory subunit beta JBrowse link 5 126,071,849 126,080,647 RGD:1624291
RGD:1600115
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:1600115
RGD:1624291
G Clca2 chloride channel accessory 2 JBrowse link 2 250,954,423 250,981,544 RGD:1624291
G Clcc1 chloride channel CLIC-like 1 JBrowse link 2 211,450,426 211,479,885 RGD:1299391
RGD:13792537
G Clcn3 chloride voltage-gated channel 3 JBrowse link 16 32,448,821 32,520,649 RGD:628537
RGD:1624291
G Clcn4 chloride voltage-gated channel 4 JBrowse link X 25,016,177 25,082,563 RGD:1624291
G Clcnka chloride voltage-gated channel Ka JBrowse link 5 159,931,497 159,946,483 RGD:68767
G Clcnkb chloride voltage-gated channel Kb JBrowse link 5 159,950,384 159,973,576 RGD:1600680
G Cldn4 claudin 4 JBrowse link 12 24,761,210 24,763,008 RGD:1624291
G Clic1 chloride intracellular channel 1 JBrowse link 20 5,040,314 5,049,166 RGD:1624291
RGD:13792537
G Clic2 chloride intracellular channel 2 JBrowse link 20 295,338 310,363 RGD:13792537
G Clic3 chloride intracellular channel 3 JBrowse link 3 2,675,732 2,678,248 RGD:1624291
RGD:13792537
G Clic4 chloride intracellular channel 4 JBrowse link 5 153,568,937 153,625,669 RGD:632350
RGD:1600115
RGD:13792537
G Clic5 chloride intracellular channel 5 JBrowse link 9 19,121,676 19,372,673 RGD:727234
RGD:13792537
G Clic6 chloride intracellular channel 6 JBrowse link 11 32,655,653 32,698,004 RGD:1600115
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 JBrowse link 10 27,310,718 27,371,802 RGD:13792537
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 JBrowse link 14 39,662,411 39,801,082 RGD:13792537
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 JBrowse link X 152,414,332 152,642,607 RGD:13792537
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 JBrowse link 14 39,154,072 39,230,994 RGD:13792537
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 JBrowse link 1 112,833,941 112,947,482 RGD:61593
RGD:13792537
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 10 27,847,447 27,862,896 RGD:61594
RGD:13792537
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 14 38,631,192 39,112,598 RGD:13792537
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 JBrowse link 10 27,973,694 28,193,072 RGD:8693370
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 JBrowse link 1 113,034,251 113,265,364 RGD:727440
G Gabrd gamma-aminobutyric acid type A receptor subunit delta JBrowse link 5 172,797,478 172,809,374 RGD:13792537
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 152,220,180 152,237,347 RGD:13792537
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 JBrowse link 14 39,964,502 40,051,306 RGD:13792537
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 JBrowse link 10 27,090,913 27,179,786 RGD:61596
RGD:13792537
RGD:1624291
G Gabrg3 gamma-aminobutyric acid type A receptor subunit gamma 3 JBrowse link 1 112,158,525 112,812,267 RGD:727524
RGD:13792537
G Gabrp gamma-aminobutyric acid type A receptor subunit pi JBrowse link 10 18,484,257 18,510,604 RGD:13792537
G Gabrq gamma-aminobutyric acid type A receptor subunit theta JBrowse link X 152,852,230 152,869,012 RGD:13792537
G Gabrr1 gamma-aminobutyric acid type A receptor subunit rho 1 JBrowse link 5 48,374,048 48,411,170 RGD:13792537
G Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 JBrowse link 5 48,303,366 48,341,571 RGD:728465
RGD:13792537
G Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 JBrowse link 11 43,046,987 43,099,754 RGD:13792537
G Glra1 glycine receptor, alpha 1 JBrowse link 10 40,851,955 40,954,364 RGD:13792537
G Glra2 glycine receptor, alpha 2 JBrowse link X 30,612,894 30,832,078 RGD:13792537
G Glra3 glycine receptor, alpha 3 JBrowse link 16 37,676,959 37,908,221 RGD:13792537
G Glra4 glycine receptor, alpha 4 JBrowse link X 107,416,019 107,447,253 RGD:13792537
G Glrb glycine receptor, beta JBrowse link 2 179,768,040 179,842,612 RGD:13792537
G Slc1a4 solute carrier family 1 member 4 JBrowse link 14 104,582,884 104,612,417 RGD:1624291
G Slc26a7 solute carrier family 26 member 7 JBrowse link 5 27,986,656 28,131,294 RGD:1624291
G Slc26a8 solute carrier family 26 member 8 JBrowse link 20 5,870,714 5,933,151 RGD:1624291
G Slc26a9 solute carrier family 26 member 9 JBrowse link 13 48,512,415 48,539,467 RGD:1624291
G Ttyh3 tweety family member 3 JBrowse link 12 16,084,078 16,112,672 RGD:1624291
extracellularly glutamate-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc17a7 solute carrier family 17 member 7 JBrowse link 1 101,161,265 101,172,292 RGD:1624291
extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Glra1 glycine receptor, alpha 1 JBrowse link 10 40,851,955 40,954,364 RGD:625689
RGD:13792537
RGD:1624291
RGD:8553668
G Glra2 glycine receptor, alpha 2 JBrowse link X 30,612,894 30,832,078 RGD:728718
RGD:13792537
RGD:1600115
RGD:1624291
G Glra3 glycine receptor, alpha 3 JBrowse link 16 37,676,959 37,908,221 RGD:728440
RGD:1624291
RGD:1600115
RGD:11035333
G Glra4 glycine receptor, alpha 4 JBrowse link X 107,416,019 107,447,253 RGD:1624291
RGD:13792537
G Glrb glycine receptor, beta JBrowse link 2 179,768,040 179,842,612 RGD:1624291
RGD:13792537
RGD:8554374
GABA-gated chloride ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 JBrowse link 10 27,310,718 27,371,802 RGD:1624291
RGD:13792537
RGD:1600115
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 JBrowse link 14 39,662,411 39,801,082 RGD:1624291
RGD:13792537
RGD:1600115
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 JBrowse link X 152,414,332 152,642,607 RGD:13792537
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 JBrowse link 14 39,154,072 39,230,994 RGD:13792537
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 JBrowse link 1 112,833,941 112,947,482 RGD:13792537
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 10 27,847,447 27,862,896 RGD:1626515
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 14 38,631,192 39,112,598 RGD:1600115
RGD:1624291
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 JBrowse link 10 27,973,694 28,193,072 RGD:1600115
RGD:1624291
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 JBrowse link 1 113,034,251 113,265,364 RGD:1600115
RGD:1624291
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 152,220,180 152,237,347 RGD:1624291
RGD:13792537
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 JBrowse link 14 39,964,502 40,051,306 RGD:13792537
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 JBrowse link 10 27,090,913 27,179,786 RGD:1600115
RGD:13792537
RGD:1624291
G Gabrg3 gamma-aminobutyric acid type A receptor subunit gamma 3 JBrowse link 1 112,158,525 112,812,267 RGD:13792537
glycine-gated chloride ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Glra2 glycine receptor, alpha 2 JBrowse link X 30,612,894 30,832,078 RGD:1624291
RGD:1600115
G Glra3 glycine receptor, alpha 3 JBrowse link 16 37,676,959 37,908,221 RGD:1600115
RGD:1624291
intracellular calcium activated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ano1 anoctamin 1 JBrowse link 1 217,754,349 217,902,540 RGD:9684846
RGD:13792537
RGD:1624291
RGD:10047211
RGD:9684847
G Ano10 anoctamin 10 JBrowse link 8 130,812,941 130,931,021 RGD:1624291
G Ano2 anoctamin 2 JBrowse link 4 158,222,650 158,577,595 RGD:9684847
RGD:13792537
RGD:1624291
G Ano3 anoctamin 3 JBrowse link 3 101,843,516 102,203,368 RGD:1624291
RGD:13792537
G Ano4 anoctamin 4 JBrowse link 7 29,492,017 30,025,587 RGD:1624291
RGD:13792537
G Ano5 anoctamin 5 JBrowse link 1 106,873,580 106,971,769 RGD:1624291
RGD:1600115
G Ano6 anoctamin 6 JBrowse link 7 137,142,063 137,335,208 RGD:1624291
G Ano7 anoctamin 7 JBrowse link 9 100,511,610 100,551,798 RGD:1624291
G Ano8 anoctamin 8 JBrowse link 16 19,884,661 19,894,608 RGD:1624291
G Ano9 anoctamin 9 JBrowse link 1 213,908,389 213,929,291 RGD:1624291
RGD:13792537
G Clca1 chloride channel accessory 1 JBrowse link 2 250,897,980 250,923,711 RGD:13792537
G Clca2 chloride channel accessory 2 JBrowse link 2 250,954,423 250,981,544 RGD:13792537
G Clca4 chloride channel accessory 4 JBrowse link 2 250,842,939 250,864,060 RGD:13792537
G Clca4l chloride channel calcium activated 4-like JBrowse link 2 250,785,534 250,805,445 RGD:13792537
G Clca5 chloride channel accessory 5 JBrowse link 2 250,755,976 250,778,269 RGD:13792537
G Clns1a chloride nucleotide-sensitive channel 1A JBrowse link 1 162,676,246 162,696,549 RGD:1624291
G Nmur2 neuromedin U receptor 2 JBrowse link 10 41,392,663 41,408,518 RGD:1624291
G Ttyh1 tweety family member 1 JBrowse link 1 73,734,614 73,753,157 RGD:13792537
G Ttyh2 tweety family member 2 JBrowse link 10 103,206,085 103,248,911 RGD:13792537
G Ttyh3 tweety family member 3 JBrowse link 12 16,084,078 16,112,672 RGD:1624291
RGD:13792537
intracellularly ATP-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:1624291
RGD:1600115
pH-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pacc1 proton activated chloride channel 1 JBrowse link 13 110,006,975 110,032,790 RGD:1600115
RGD:1624291
voltage-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ano1 anoctamin 1 JBrowse link 1 217,754,349 217,902,540 RGD:1624291
G Ano6 anoctamin 6 JBrowse link 7 137,142,063 137,335,208 RGD:1624291
G Clcn1 chloride voltage-gated channel 1 JBrowse link 4 71,674,218 71,704,318 RGD:727583
RGD:13792537
RGD:1624291
RGD:1600115
G Clcn2 chloride voltage-gated channel 2 JBrowse link 11 82,862,664 82,876,165 RGD:69809
RGD:13792537
RGD:1624291
G Clcn3 chloride voltage-gated channel 3 JBrowse link 16 32,448,821 32,520,649 RGD:628537
RGD:13792537
RGD:1600115
G Clcn4 chloride voltage-gated channel 4 JBrowse link X 25,016,177 25,082,563 RGD:1600115
RGD:13792537
G Clcn5 chloride voltage-gated channel 5 JBrowse link X 16,170,585 16,196,691 RGD:727659
RGD:13792537
RGD:1600115
G Clcn6 chloride voltage-gated channel 6 JBrowse link 5 164,811,815 164,844,554 RGD:1600115
G Clcn7 chloride voltage-gated channel 7 JBrowse link 10 14,492,844 14,518,167 RGD:1600115
G Clcnka chloride voltage-gated channel Ka JBrowse link 5 159,931,497 159,946,483 RGD:1600115
RGD:13792537
G Clcnkb chloride voltage-gated channel Kb JBrowse link 5 159,950,384 159,973,576 RGD:1600115
RGD:13792537
G Clic1 chloride intracellular channel 1 JBrowse link 20 5,040,314 5,049,166 RGD:1304001
G LOC108348101 chloride channel protein 2 JBrowse link 11 83,883,428 83,897,396 RGD:1600115
RGD:13792537
volume-sensitive chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcn3 chloride voltage-gated channel 3 JBrowse link 16 32,448,821 32,520,649 RGD:1624291
RGD:1600115
G Ttyh1 tweety family member 1 JBrowse link 1 73,734,614 73,753,157 RGD:1624291
RGD:13792537
G Ttyh2 tweety family member 2 JBrowse link 10 103,206,085 103,248,911 RGD:13792537
G Ttyh3 tweety family member 3 JBrowse link 12 16,084,078 16,112,672 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20377
    transporter activity 1242
      transmembrane transporter activity 1106
        ion transmembrane transporter activity 893
          ion channel activity 442
            anion channel activity 86
              chloride channel activity 75
                GABA-gated chloride ion channel activity 13
                extracellularly glutamate-gated chloride channel activity 1
                extracellularly glycine-gated chloride channel activity 5
                glycine-gated chloride ion channel activity 2
                histamine-gated chloride channel activity 0
                intracellular chloride channel activity + 20
                intracellularly ATP-gated chloride channel activity 1
                pH-gated chloride channel activity 1
                voltage-gated chloride channel activity + 13
                volume-sensitive chloride channel activity 4
Path 2
Term Annotations click to browse term
  molecular_function 20377
    transporter activity 1242
      transmembrane transporter activity 1106
        ion transmembrane transporter activity 893
          anion transmembrane transporter activity 360
            inorganic anion transmembrane transporter activity 141
              anion channel activity 86
                chloride channel activity 75
                  GABA-gated chloride ion channel activity 13
                  extracellularly glutamate-gated chloride channel activity 1
                  extracellularly glycine-gated chloride channel activity 5
                  glycine-gated chloride ion channel activity 2
                  histamine-gated chloride channel activity 0
                  intracellular chloride channel activity + 20
                  intracellularly ATP-gated chloride channel activity 1
                  pH-gated chloride channel activity 1
                  voltage-gated chloride channel activity + 13
                  volume-sensitive chloride channel activity 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.