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ONTOLOGY REPORT - ANNOTATIONS


Term:chloride channel activity
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Accession:GO:0005254 term browser browse the term
Definition:Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
Synonyms:xref: Reactome:R-HSA-975449 "GABRR pentamers:GABA transports extracellular Cl- to cytosol";   reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region";   reactome:R-HSA-427570 "Group 3 - Selective Cl- transport";   reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol"


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chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANO1 anoctamin 1 JBrowse link 18 48,108,310 48,249,021 RGD:13508589
G ANO3 anoctamin 3 JBrowse link 21 47,046,020 47,416,360 RGD:13508589
G ANO4 anoctamin 4 JBrowse link 15 39,740,496 40,149,039 RGD:13508589
G ANO5 anoctamin 5 JBrowse link 21 43,903,422 43,986,778 RGD:13508589
G ANO6 anoctamin 6 JBrowse link 27 8,882,691 9,067,057 RGD:13508589
G ANO7 anoctamin 7 JBrowse link 25 51,209,628 51,226,581 RGD:13508589
G ANO9 anoctamin 9 JBrowse link 18 25,556,356 25,570,242 RGD:13508589
G BEST1 bestrophin 1 JBrowse link 18 54,468,844 54,483,565 RGD:13508589
RGD:9068941
G BEST2 bestrophin 2 JBrowse link 20 49,384,595 49,388,758 RGD:13508589
RGD:9068941
G BEST3 bestrophin 3 JBrowse link 10 11,598,331 11,637,516 RGD:13508589
G BEST4 bestrophin 4 JBrowse link 15 15,535,179 15,539,047 RGD:13508589
G BSND barttin CLCNK type accessory subunit beta JBrowse link 5 54,225,393 54,239,305 RGD:13508589
RGD:9068941
G CFTR CF transmembrane conductance regulator JBrowse link 14 56,290,417 56,452,919 RGD:13508589
G CLCA2 chloride channel accessory 2 JBrowse link 6 61,665,120 61,705,760 RGD:9068941
G CLCC1 chloride channel CLIC like 1 JBrowse link 6 42,807,432 42,829,317 RGD:13508589
G CLCN3 chloride voltage-gated channel 3 JBrowse link 25 20,528,708 20,616,687 RGD:9068941
G CLCN4 chloride voltage-gated channel 4 JBrowse link X 6,853,184 6,921,478 RGD:9068941
G CLCNKA chloride voltage-gated channel Ka JBrowse link 2 81,612,382 81,627,742 RGD:9068941
G CLDN4 claudin 4 JBrowse link 6 6,492,706 6,506,750 RGD:13508589
G CLIC1 chloride intracellular channel 1 JBrowse link 12 1,209,777 1,215,229 RGD:13508589
G CLIC2 chloride intracellular channel 2 JBrowse link X 123,268,867 123,291,467 RGD:13508589
G CLIC3 chloride intracellular channel 3 JBrowse link 9 48,634,061 48,637,083 RGD:13508589
G CLIC4 chloride intracellular channel 4 JBrowse link 2 74,903,653 74,974,103 RGD:13508589
G CLIC5 chloride intracellular channel 5 JBrowse link 12 14,160,524 14,318,174 RGD:13508589
G CLIC6 chloride intracellular channel 6 JBrowse link 31 30,003,448 30,102,939 RGD:13508589
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 JBrowse link 4 49,006,981 49,065,205 RGD:13508589
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 JBrowse link 13 42,367,988 42,488,069 RGD:13508589
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 JBrowse link X 120,152,650 120,460,604 RGD:13508589
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 JBrowse link 13 42,889,100 42,958,604 RGD:13508589
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 JBrowse link 3 33,663,414 33,746,120 RGD:13508589
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 4 49,208,691 49,225,754 RGD:13508589
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 13 43,011,491 43,349,876 RGD:13508589
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 JBrowse link 4 49,342,527 49,579,697 RGD:9068941
RGD:13508589
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 JBrowse link 3 33,878,948 34,101,987 RGD:9068941
RGD:13508589
G GABRD gamma-aminobutyric acid type A receptor subunit delta JBrowse link 5 56,984,786 56,994,790 RGD:13508589
G GABRE gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 119,913,867 119,937,867 RGD:13508589
G GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 JBrowse link 13 42,194,929 42,276,379 RGD:13508589
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 JBrowse link 4 48,794,770 48,901,859 RGD:13508589
G GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 JBrowse link 3 32,956,061 33,641,971 RGD:13508589
G GABRP gamma-aminobutyric acid type A receptor subunit pi JBrowse link 4 41,164,725 41,186,716 RGD:13508589
G GABRQ gamma-aminobutyric acid type A receptor subunit theta JBrowse link X 120,607,815 120,630,251 RGD:13508589
G GABRR1 gamma-aminobutyric acid type A receptor subunit rho1 JBrowse link 12 48,431,273 48,465,426 RGD:13508589
G GABRR2 gamma-aminobutyric acid type A receptor subunit rho2 JBrowse link 12 48,492,607 48,537,961 RGD:13508589
G GLRA1 glycine receptor alpha 1 JBrowse link 4 57,443,094 57,541,494 RGD:13508589
G GLRA2 glycine receptor alpha 2 JBrowse link X 10,859,699 11,033,386 RGD:13508589
G GLRA3 glycine receptor alpha 3 JBrowse link 25 25,098,280 25,305,511 RGD:13508589
G GLRA4 glycine receptor alpha 4 (pseudogene) JBrowse link X 77,115,962 77,142,381 RGD:13508589
G GLRB glycine receptor beta JBrowse link 15 54,429,131 54,519,844 RGD:13508589
G LOC100685953 chloride intracellular channel protein 1 pseudogene JBrowse link 16 31,230,263 31,231,112 RGD:13508589
G LOC474947 chloride intracellular channel 1 pseudogene JBrowse link 12 23,712,494 23,713,462 RGD:13508589
G LOC477430 protein phosphatase 1 regulatory subunit 7-like RGD:13508589
G LOC610493 chloride intracellular channel 1 pseudogene JBrowse link 12 46,833,909 46,834,715 RGD:13508589
G SLC1A4 solute carrier family 1 member 4 JBrowse link 10 64,482,840 64,508,288 RGD:13508589
G SLC26A7 solute carrier family 26 member 7 JBrowse link 29 36,616,054 36,729,705 RGD:13508589
G SLC26A8 solute carrier family 26 member 8 JBrowse link 12 5,059,267 5,145,387 RGD:13508589
G SLC26A9 solute carrier family 26 member 9 JBrowse link 38 2,267,404 2,303,997 RGD:13508589
G TTYH1 tweety family member 1 JBrowse link 1 102,860,633 102,876,065 RGD:13508589
G TTYH3 tweety family member 3 JBrowse link 6 14,595,357 14,625,417 RGD:13508589
extracellularly glutamate-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SLC17A7 solute carrier family 17 member 7 JBrowse link 1 107,054,242 107,064,444 RGD:13508589
extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLRA1 glycine receptor alpha 1 JBrowse link 4 57,443,094 57,541,494 RGD:9068941
RGD:13508589
G GLRA2 glycine receptor alpha 2 JBrowse link X 10,859,699 11,033,386 RGD:13508589
G GLRA3 glycine receptor alpha 3 JBrowse link 25 25,098,280 25,305,511 RGD:13508589
G GLRA4 glycine receptor alpha 4 (pseudogene) JBrowse link X 77,115,962 77,142,381 RGD:9068941
RGD:13508589
G GLRB glycine receptor beta JBrowse link 15 54,429,131 54,519,844 RGD:13508589
GABA-gated chloride ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 JBrowse link 4 49,006,981 49,065,205 RGD:13508589
RGD:9068941
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 JBrowse link 13 42,367,988 42,488,069 RGD:13508589
RGD:9068941
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 JBrowse link X 120,152,650 120,460,604 RGD:13508589
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 JBrowse link 13 42,889,100 42,958,604 RGD:13508589
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 JBrowse link 3 33,663,414 33,746,120 RGD:13508589
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 4 49,208,691 49,225,754 RGD:13508589
RGD:9068941
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 13 43,011,491 43,349,876 RGD:9068941
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 JBrowse link 4 49,342,527 49,579,697 RGD:9068941
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 JBrowse link 3 33,878,948 34,101,987 RGD:13508589
RGD:9068941
G GABRE gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 119,913,867 119,937,867 RGD:13508589
G GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 JBrowse link 13 42,194,929 42,276,379 RGD:13508589
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 JBrowse link 4 48,794,770 48,901,859 RGD:13508589
RGD:9068941
G GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 JBrowse link 3 32,956,061 33,641,971 RGD:13508589
glycine-gated chloride ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLRA2 glycine receptor alpha 2 JBrowse link X 10,859,699 11,033,386 RGD:13508589
G GLRA3 glycine receptor alpha 3 JBrowse link 25 25,098,280 25,305,511 RGD:13508589
intracellular calcium activated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANO1 anoctamin 1 JBrowse link 18 48,108,310 48,249,021 RGD:13508589
G ANO10 anoctamin 10 JBrowse link 23 2,678,659 2,900,490 RGD:13508589
RGD:9068941
G ANO2 anoctamin 2 JBrowse link 27 38,976,761 39,320,764 RGD:9068941
G ANO3 anoctamin 3 JBrowse link 21 47,046,020 47,416,360 RGD:9068941
RGD:13508589
G ANO4 anoctamin 4 JBrowse link 15 39,740,496 40,149,039 RGD:9068941
RGD:13508589
G ANO5 anoctamin 5 JBrowse link 21 43,903,422 43,986,778 RGD:13508589
RGD:9068941
G ANO6 anoctamin 6 JBrowse link 27 8,882,691 9,067,057 RGD:9068941
G ANO7 anoctamin 7 JBrowse link 25 51,209,628 51,226,581 RGD:13508589
RGD:9068941
G ANO8 anoctamin 8 JBrowse link 20 45,428,532 45,437,897 RGD:9068941
G ANO9 anoctamin 9 JBrowse link 18 25,556,356 25,570,242 RGD:9068941
RGD:13508589
G CLCA1 chloride channel accessory 1 JBrowse link 6 61,620,755 61,650,111 RGD:13508589
G CLCA2 chloride channel accessory 2 JBrowse link 6 61,665,120 61,705,760 RGD:13508589
G CLCA4 chloride channel accessory 4 JBrowse link 6 61,559,472 61,584,601 RGD:13508589
G CLNS1A chloride nucleotide-sensitive channel 1A JBrowse link 21 21,136,913 21,177,678 RGD:13508589
G NMUR2 neuromedin U receptor 2 JBrowse link 4 56,994,731 57,018,429 RGD:13508589
G TTYH1 tweety family member 1 JBrowse link 1 102,860,633 102,876,065 RGD:13508589
G TTYH2 tweety family member 2 JBrowse link 9 6,120,586 6,156,956 RGD:13508589
G TTYH3 tweety family member 3 JBrowse link 6 14,595,357 14,625,417 RGD:13508589
intracellularly ATP-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CFTR CF transmembrane conductance regulator JBrowse link 14 56,290,417 56,452,919 RGD:13508589
pH-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PACC1 proton activated chloride channel 1 JBrowse link 7 10,568,030 10,606,672 RGD:9068941
voltage-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANO1 anoctamin 1 JBrowse link 18 48,108,310 48,249,021 RGD:9068941
G ANO6 anoctamin 6 JBrowse link 27 8,882,691 9,067,057 RGD:9068941
G CLCN1 chloride voltage-gated channel 1 JBrowse link 16 6,342,772 6,373,580 RGD:13508589
G CLCN2 chloride voltage-gated channel 2 JBrowse link 34 17,224,136 17,238,755 RGD:13508589
G CLCN3 chloride voltage-gated channel 3 JBrowse link 25 20,528,708 20,616,687 RGD:13508589
G CLCN4 chloride voltage-gated channel 4 JBrowse link X 6,853,184 6,921,478 RGD:13508589
G CLCN5 chloride voltage-gated channel 5 JBrowse link X 42,705,789 42,860,701 RGD:13508589
G CLCN6 chloride voltage-gated channel 6 JBrowse link 2 84,410,740 84,443,874 RGD:13508589
G CLCN7 chloride voltage-gated channel 7 JBrowse link 6 39,331,100 39,356,477 RGD:13508589
G CLCNKA chloride voltage-gated channel Ka JBrowse link 2 81,612,382 81,627,742 RGD:13508589
volume-sensitive chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLCN3 chloride voltage-gated channel 3 JBrowse link 25 20,528,708 20,616,687 RGD:9068941
G TTYH1 tweety family member 1 JBrowse link 1 102,860,633 102,876,065 RGD:13508589
G TTYH2 tweety family member 2 JBrowse link 9 6,120,586 6,156,956 RGD:13508589
G TTYH3 tweety family member 3 JBrowse link 6 14,595,357 14,625,417 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16927
    transporter activity 1180
      transmembrane transporter activity 1056
        ion transmembrane transporter activity 867
          ion channel activity 433
            anion channel activity 84
              chloride channel activity 73
                GABA-gated chloride ion channel activity 13
                extracellularly glutamate-gated chloride channel activity 1
                extracellularly glycine-gated chloride channel activity 5
                glycine-gated chloride ion channel activity 2
                histamine-gated chloride channel activity 0
                intracellular chloride channel activity + 18
                intracellularly ATP-gated chloride channel activity 1
                pH-gated chloride channel activity 1
                voltage-gated chloride channel activity + 10
                volume-sensitive chloride channel activity 4
Path 2
Term Annotations click to browse term
  molecular_function 16927
    transporter activity 1180
      transmembrane transporter activity 1056
        ion transmembrane transporter activity 867
          anion transmembrane transporter activity 345
            inorganic anion transmembrane transporter activity 142
              anion channel activity 84
                chloride channel activity 73
                  GABA-gated chloride ion channel activity 13
                  extracellularly glutamate-gated chloride channel activity 1
                  extracellularly glycine-gated chloride channel activity 5
                  glycine-gated chloride ion channel activity 2
                  histamine-gated chloride channel activity 0
                  intracellular chloride channel activity + 18
                  intracellularly ATP-gated chloride channel activity 1
                  pH-gated chloride channel activity 1
                  voltage-gated chloride channel activity + 10
                  volume-sensitive chloride channel activity 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.