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ONTOLOGY REPORT - ANNOTATIONS


Term:chloride channel activity
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Accession:GO:0005254 term browser browse the term
Definition:Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
Synonyms:xref: Reactome:R-HSA-975449 "GABRR pentamers:GABA transports extracellular Cl- to cytosol";   reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region";   reactome:R-HSA-427570 "Group 3 - Selective Cl- transport";   reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol"


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chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCC4 ATP binding cassette subfamily C member 4 JBrowse link 11 64,089,149 64,309,831 RGD:14298760
G ANO1 anoctamin 1 JBrowse link 2 3,202,269 3,373,409 RGD:14298760
G ANO2 anoctamin 2 JBrowse link 5 64,660,047 65,002,453 RGD:14298760
G ANO3 anoctamin 3 JBrowse link 2 33,618,740 34,048,973 RGD:14298760
G ANO4 anoctamin 4 JBrowse link 5 83,052,070 83,489,523 RGD:14298760
G ANO5 anoctamin 5 JBrowse link 2 37,171,402 37,256,204 RGD:14298760
G ANO6 anoctamin 6 JBrowse link 5 76,112,428 76,337,073 RGD:14298760
G ANO9 anoctamin 9 JBrowse link 2 232,761 250,966 RGD:14298760
G BEST1 bestrophin 1 JBrowse link 2 9,538,082 9,550,975 RGD:14298760
RGD:9068941
G BEST2 bestrophin 2 JBrowse link 2 66,242,820 66,248,908 RGD:14298760
RGD:9068941
G BEST3 bestrophin 3 JBrowse link 5 33,909,973 33,957,171 RGD:14298760
G BEST4 bestrophin 4 JBrowse link 6 166,540,767 166,547,149 RGD:14298760
G BSND barttin CLCNK type accessory subunit beta JBrowse link 6 157,424,389 157,432,571 RGD:14298760
RGD:9068941
G CFTR CF transmembrane conductance regulator JBrowse link 18 28,627,717 28,818,209 RGD:14298760
G CLCA2 chloride channel accessory 2 JBrowse link 4 129,670,634 129,704,765 RGD:9068941
G CLCC1 chloride channel CLIC like 1 JBrowse link 4 111,080,648 111,101,007 RGD:14298760
G CLCN3 chloride voltage-gated channel 3 JBrowse link 14 20,037,628 20,127,160 RGD:9068941
G CLCN4 chloride voltage-gated channel 4 JBrowse link X 6,939,637 7,019,745 RGD:9068941
G CLDN17 claudin 17 JBrowse link 13 193,516,598 193,517,462 RGD:14298760
G CLDN4 claudin 4 JBrowse link 3 11,039,711 11,053,930 RGD:9068941
G CLIC1 chloride intracellular channel 1 JBrowse link 7 23,842,829 23,851,162 RGD:14298760
G CLIC1 chloride intracellular channel 1 JBrowse link 6 160,010,109 160,011,707 RGD:14298760
G CLIC2 chloride intracellular channel 2 JBrowse link X 125,546,451 125,560,059 RGD:14298760
G CLIC3 chloride intracellular channel 3 RGD:14298760
G CLIC4 chloride intracellular channel 4 JBrowse link 6 82,401,041 82,483,038 RGD:14298760
G CLIC5 chloride intracellular channel 5 JBrowse link 7 40,683,044 40,808,017 RGD:14298760
G CLIC6 chloride intracellular channel 6 JBrowse link 13 198,250,702 198,303,830 RGD:14298760
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 JBrowse link 16 61,656,583 61,723,428 RGD:14298760
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 JBrowse link 8 36,344,633 36,474,840 RGD:14298760
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 JBrowse link X 123,456,952 123,684,814 RGD:14298760
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 JBrowse link 8 36,875,649 36,943,016 RGD:14298760
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 JBrowse link 1 140,486,107 140,568,204 RGD:14298760
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 16 61,855,698 61,872,503 RGD:14298760
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 8 36,978,014 37,354,950 RGD:14298760
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 JBrowse link 16 61,984,923 62,240,902 RGD:9068941
RGD:14298760
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 JBrowse link 1 140,566,443 140,906,516 RGD:9068941
RGD:14298760
G GABRD gamma-aminobutyric acid type A receptor subunit delta JBrowse link 6 64,049,665 64,059,644 RGD:14298760
G GABRE gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 123,278,459 123,296,070 RGD:14298760
G GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 JBrowse link 8 36,198,056 36,262,492 RGD:14298760
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 JBrowse link 16 61,441,622 61,543,375 RGD:14298760
G GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 JBrowse link 1 139,855,461 140,464,592 RGD:14298760
G GABRQ gamma-aminobutyric acid type A receptor subunit theta JBrowse link X 123,834,884 123,855,187 RGD:14298760
G GABRR2 gamma-aminobutyric acid type A receptor subunit rho2 JBrowse link 1 57,287,265 57,332,342 RGD:14298760
G GLRA1 glycine receptor alpha 1 JBrowse link 16 71,140,751 71,236,867 RGD:14298760
G GLRA2 glycine receptor alpha 2 JBrowse link X 11,111,655 11,288,496 RGD:14298760
G GLRA3 glycine receptor alpha 3 JBrowse link 14 15,120,091 15,603,509 RGD:14298760
G GLRA4 glycine receptor alpha 4 JBrowse link X 84,584,907 84,612,860 RGD:14298760
G GLRB glycine receptor beta JBrowse link 8 45,912,869 46,034,455 RGD:14298760
G LOC100518860 multidrug resistance-associated protein 4-like RGD:14298760
G SLC1A4 solute carrier family 1 member 4 JBrowse link 3 76,938,102 76,970,519 RGD:14298760
G SLC26A7 solute carrier family 26 member 7 JBrowse link 4 45,410,795 45,637,500 RGD:14298760
G SLC26A8 solute carrier family 26 member 8 JBrowse link 7 31,722,409 31,791,620 RGD:14298760
G SLC26A9 solute carrier family 26 member 9 JBrowse link 9 66,557,560 66,593,322 RGD:14298760
G TTYH1 tweety family member 1 JBrowse link 6 58,870,792 58,891,600 RGD:14298760
G TTYH2 tweety family member 2 JBrowse link 12 6,838,420 6,881,562 RGD:14298760
G TTYH3 tweety family member 3 JBrowse link 3 1,826,284 1,853,522 RGD:9068941
extracellularly glutamate-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SLC17A7 solute carrier family 17 member 7 JBrowse link 6 54,511,121 54,521,616 RGD:9068941
extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLRA1 glycine receptor alpha 1 JBrowse link 16 71,140,751 71,236,867 RGD:9068941
RGD:14298760
G GLRA2 glycine receptor alpha 2 JBrowse link X 11,111,655 11,288,496 RGD:14298760
G GLRA3 glycine receptor alpha 3 JBrowse link 14 15,120,091 15,603,509 RGD:14298760
G GLRA4 glycine receptor alpha 4 JBrowse link X 84,584,907 84,612,860 RGD:9068941
RGD:14298760
G GLRB glycine receptor beta JBrowse link 8 45,912,869 46,034,455 RGD:14298760
GABA-gated chloride ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 JBrowse link 16 61,656,583 61,723,428 RGD:14298760
RGD:9068941
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 JBrowse link 8 36,344,633 36,474,840 RGD:14298760
RGD:9068941
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 JBrowse link X 123,456,952 123,684,814 RGD:14298760
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 JBrowse link 8 36,875,649 36,943,016 RGD:14298760
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 JBrowse link 1 140,486,107 140,568,204 RGD:14298760
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 16 61,855,698 61,872,503 RGD:14298760
RGD:9068941
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 8 36,978,014 37,354,950 RGD:14298760
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 JBrowse link 16 61,984,923 62,240,902 RGD:9068941
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 JBrowse link 1 140,566,443 140,906,516 RGD:14298760
RGD:9068941
G GABRE gamma-aminobutyric acid type A receptor subunit epsilon JBrowse link X 123,278,459 123,296,070 RGD:14298760
G GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 JBrowse link 8 36,198,056 36,262,492 RGD:14298760
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 JBrowse link 16 61,441,622 61,543,375 RGD:14298760
RGD:9068941
G GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 JBrowse link 1 139,855,461 140,464,592 RGD:14298760
glycine-gated chloride ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLRA2 glycine receptor alpha 2 JBrowse link X 11,111,655 11,288,496 RGD:14298760
G GLRA3 glycine receptor alpha 3 JBrowse link 14 15,120,091 15,603,509 RGD:14298760
intracellular calcium activated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANO1 anoctamin 1 JBrowse link 2 3,202,269 3,373,409 RGD:14298760
G ANO10 anoctamin 10 JBrowse link 13 26,734,098 27,006,163 RGD:14298760
RGD:9068941
G ANO2 anoctamin 2 JBrowse link 5 64,660,047 65,002,453 RGD:14298760
G ANO3 anoctamin 3 JBrowse link 2 33,618,740 34,048,973 RGD:9068941
RGD:14298760
G ANO4 anoctamin 4 JBrowse link 5 83,052,070 83,489,523 RGD:9068941
RGD:14298760
G ANO5 anoctamin 5 JBrowse link 2 37,171,402 37,256,204 RGD:14298760
RGD:9068941
G ANO6 anoctamin 6 JBrowse link 5 76,112,428 76,337,073 RGD:14298760
RGD:9068941
G ANO7 anoctamin 7 JBrowse link 15 139,951,191 139,956,575 RGD:9068941
G ANO8 anoctamin 8 JBrowse link 2 60,357,194 60,367,248 RGD:14298760
RGD:9068941
G ANO9 anoctamin 9 JBrowse link 2 232,761 250,966 RGD:9068941
RGD:14298760
G CLCA1 chloride channel accessory 1 JBrowse link 4 129,621,259 129,655,385 RGD:14298760
G CLCA2 chloride channel accessory 2 JBrowse link 4 129,670,634 129,704,765 RGD:14298760
G CLCA4 calcium-activated chloride channel regulator 4 JBrowse link 4 129,562,573 129,593,123 RGD:14298760
G CLNS1A chloride nucleotide-sensitive channel 1A JBrowse link 9 12,092,990 12,113,668 RGD:9068941
G LOC100512780 calcium-activated chloride channel regulator 4-like JBrowse link 4 129,491,593 129,537,399 RGD:14298760
G NMUR2 neuromedin U receptor 2 JBrowse link 16 70,659,732 70,672,346 RGD:14298760
G TTYH1 tweety family member 1 JBrowse link 6 58,870,792 58,891,600 RGD:14298760
G TTYH2 tweety family member 2 JBrowse link 12 6,838,420 6,881,562 RGD:14298760
G TTYH3 tweety family member 3 JBrowse link 3 1,826,284 1,853,522 RGD:14298760
intracellularly ATP-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CFTR CF transmembrane conductance regulator JBrowse link 18 28,627,717 28,818,209 RGD:14298760
pH-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PACC1 proton activated chloride channel 1 JBrowse link 9 130,968,208 131,001,491 RGD:14298760
voltage-gated chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANO1 anoctamin 1 JBrowse link 2 3,202,269 3,373,409 RGD:9068941
G ANO6 anoctamin 6 JBrowse link 5 76,112,428 76,337,073 RGD:14298760
G CLCN1 chloride voltage-gated channel 1 JBrowse link 18 6,902,540 6,941,530 RGD:14298760
G CLCN2 chloride voltage-gated channel 2 JBrowse link 13 122,234,731 122,249,889 RGD:14298760
G CLCN3 chloride voltage-gated channel 3 JBrowse link 14 20,037,628 20,127,160 RGD:14298760
G CLCN4 chloride voltage-gated channel 4 JBrowse link X 6,939,637 7,019,745 RGD:14298760
G CLCN5 chloride voltage-gated channel 5 JBrowse link X 43,779,016 43,809,472 RGD:14298760
G CLCN6 chloride voltage-gated channel 6 JBrowse link 6 71,881,912 71,915,016 RGD:14298760
G CLCN7 chloride voltage-gated channel 7 JBrowse link 3 40,397,807 40,420,960 RGD:14298760
G CLCNKA chloride channel protein ClC-Ka JBrowse link 6 75,178,914 75,192,670 RGD:14298760
volume-sensitive chloride channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLCN3 chloride voltage-gated channel 3 JBrowse link 14 20,037,628 20,127,160 RGD:14298760
RGD:9068941
G TTYH1 tweety family member 1 JBrowse link 6 58,870,792 58,891,600 RGD:14298760
G TTYH2 tweety family member 2 JBrowse link 12 6,838,420 6,881,562 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17331
    transporter activity 1170
      transmembrane transporter activity 1041
        ion transmembrane transporter activity 845
          ion channel activity 428
            anion channel activity 82
              chloride channel activity 72
                GABA-gated chloride ion channel activity 13
                extracellularly glutamate-gated chloride channel activity 1
                extracellularly glycine-gated chloride channel activity 5
                glycine-gated chloride ion channel activity 2
                histamine-gated chloride channel activity 0
                intracellular chloride channel activity + 19
                intracellularly ATP-gated chloride channel activity 1
                pH-gated chloride channel activity 1
                voltage-gated chloride channel activity + 10
                volume-sensitive chloride channel activity 3
Path 2
Term Annotations click to browse term
  molecular_function 17331
    transporter activity 1170
      transmembrane transporter activity 1041
        ion transmembrane transporter activity 845
          anion transmembrane transporter activity 347
            inorganic anion transmembrane transporter activity 137
              anion channel activity 82
                chloride channel activity 72
                  GABA-gated chloride ion channel activity 13
                  extracellularly glutamate-gated chloride channel activity 1
                  extracellularly glycine-gated chloride channel activity 5
                  glycine-gated chloride ion channel activity 2
                  histamine-gated chloride channel activity 0
                  intracellular chloride channel activity + 19
                  intracellularly ATP-gated chloride channel activity 1
                  pH-gated chloride channel activity 1
                  voltage-gated chloride channel activity + 10
                  volume-sensitive chloride channel activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.