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ONTOLOGY REPORT - ANNOTATIONS


Term:sodium channel activity
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Accession:GO:0005272 term browser browse the term
Definition:Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
Synonyms:xref: reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports cytosolic Na+ to extracellular region";   reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol"


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sodium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asic4 acid sensing ion channel subunit family member 4 JBrowse link 9 82,647,071 82,668,920 RGD:1600115
G Asic5 acid sensing ion channel subunit family member 5 JBrowse link 2 180,935,392 180,964,365 RGD:1624291
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 JBrowse link 2 50,099,576 50,499,799 RGD:1600115
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 JBrowse link 7 12,851,730 12,870,087 RGD:1600115
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 JBrowse link 8 63,599,907 63,637,327 RGD:1600115
G Kcnk1 potassium two pore domain channel subfamily K member 1 JBrowse link 19 58,823,836 58,862,926 RGD:1624291
RGD:1600115
G Nalcn sodium leak channel, non-selective JBrowse link 15 109,734,092 110,046,729 RGD:1600115
G Pkd2l1 polycystin 2 like 1, transient receptor potential cation channel JBrowse link 1 263,922,201 263,959,318 RGD:1624291
RGD:13792537
G Scn7a sodium voltage-gated channel alpha subunit 7 JBrowse link 3 52,775,779 52,877,365 RGD:634044
RGD:1624291
G Scnn1a sodium channel epithelial 1 alpha subunit JBrowse link 4 157,834,339 157,860,472 RGD:1624291
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:1624291
G Scnn1g sodium channel epithelial 1 gamma subunit JBrowse link 1 191,704,397 191,738,271 RGD:1624291
G Slc4a11 solute carrier family 4 member 11 JBrowse link 3 123,224,242 123,236,535 RGD:1624291
RGD:1600115
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 JBrowse link 20 11,434,062 11,482,880 RGD:1600115
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 JBrowse link 1 216,256,653 216,281,504 RGD:1624291
RGD:1600115
acid-sensing ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asic1 acid sensing ion channel subunit 1 JBrowse link 7 141,324,714 141,354,937 RGD:1624291
RGD:1600115
kainate selective glutamate receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:8553303
G Grik1 glutamate ionotropic receptor kainate type subunit 1 JBrowse link 11 27,811,954 28,213,940 RGD:1642466
RGD:13792537
RGD:1624291
G Grik2 glutamate ionotropic receptor kainate type subunit 2 JBrowse link 20 53,791,428 54,517,691 RGD:69852
RGD:13792537
RGD:1624291
G Grik3 glutamate ionotropic receptor kainate type subunit 3 JBrowse link 5 143,500,441 143,715,546 RGD:1600115
RGD:13792537
RGD:1624291
G Grik4 glutamate ionotropic receptor kainate type subunit 4 JBrowse link 8 46,804,134 47,237,546 RGD:734533
RGD:13792537
G Grik5 glutamate ionotropic receptor kainate type subunit 5 JBrowse link 1 81,885,516 81,946,731 RGD:625595
RGD:13792537
RGD:1624291
ligand-gated sodium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asic1 acid sensing ion channel subunit 1 JBrowse link 7 141,324,714 141,354,937 RGD:1600115
G Asic2 acid sensing ion channel subunit 2 JBrowse link 10 68,247,800 69,347,223 RGD:1600115
RGD:1624291
G Asic3 acid sensing ion channel subunit 3 JBrowse link 4 7,287,868 7,293,295 RGD:1299543
G Asic5 acid sensing ion channel subunit family member 5 JBrowse link 2 180,935,392 180,964,365 RGD:631861
RGD:1624291
G Scnn1a sodium channel epithelial 1 alpha subunit JBrowse link 4 157,834,339 157,860,472 RGD:1624119
RGD:1624291
RGD:1600115
RGD:1624121
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:729911
RGD:1624291
RGD:1600115
RGD:1624140
RGD:1624121
G Scnn1g sodium channel epithelial 1 gamma subunit JBrowse link 1 191,704,397 191,738,271 RGD:729911
RGD:1624291
RGD:1600115
RGD:1624121
RGD:1624119
G Tpcn1 two pore segment channel 1 JBrowse link 12 41,507,784 41,566,847 RGD:1624291
voltage-gated sodium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asic2 acid sensing ion channel subunit 2 JBrowse link 10 68,247,800 69,347,223 RGD:1298619
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:13792537
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:13792537
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:13792537
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 JBrowse link 2 50,099,576 50,499,799 RGD:1600115
RGD:1624291
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 JBrowse link 7 12,851,730 12,870,087 RGD:1600115
RGD:1624291
G Hcn3 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 JBrowse link 2 188,458,851 188,471,916 RGD:1624291
RGD:1600115
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 JBrowse link 8 63,599,907 63,637,327 RGD:1600115
RGD:1624291
G Pkd2 polycystin 2, transient receptor potential cation channel JBrowse link 14 6,602,004 6,645,257 RGD:1624291
RGD:13792537
G Scn10a sodium voltage-gated channel alpha subunit 10 JBrowse link 8 128,298,593 128,416,896 RGD:69979
RGD:13792537
RGD:1624291
G Scn11a sodium voltage-gated channel alpha subunit 11 JBrowse link 8 128,450,793 128,527,510 RGD:1624291
RGD:13792537
RGD:1600115
G Scn1a sodium voltage-gated channel alpha subunit 1 JBrowse link 3 52,388,811 52,533,365 RGD:68844
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2289022
RGD:2289019
RGD:1599536
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:1624291
G Scn2a sodium voltage-gated channel alpha subunit 2 JBrowse link 3 51,687,910 51,822,008 RGD:1299025
RGD:13792537
RGD:14390052
RGD:1624291
RGD:1600115
RGD:8554774
RGD:2289019
RGD:1599536
G Scn2b sodium voltage-gated channel beta subunit 2 JBrowse link 8 49,419,003 49,431,110 RGD:729729
G Scn3a sodium voltage-gated channel alpha subunit 3 JBrowse link 3 51,530,897 51,643,140 RGD:734493
RGD:13792537
RGD:1600115
RGD:1599536
G Scn4a sodium voltage-gated channel alpha subunit 4 JBrowse link 10 94,505,026 94,557,803 RGD:634040
RGD:13792537
RGD:1624291
RGD:1600115
G Scn4b sodium voltage-gated channel beta subunit 4 JBrowse link 8 49,441,106 49,456,279 RGD:1624291
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1600115
RGD:13792537
RGD:1624291
G Scn7a sodium voltage-gated channel alpha subunit 7 JBrowse link 3 52,775,779 52,877,365 RGD:13792537
G Scn8a sodium voltage-gated channel alpha subunit 8 JBrowse link 7 142,575,629 142,683,659 RGD:69984
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2289022
RGD:2289019
RGD:1599536
G Scn9a sodium voltage-gated channel alpha subunit 9 JBrowse link 3 52,583,953 52,664,209 RGD:1599536
RGD:13792537
RGD:1600115
RGD:1624291
G Tpcn1 two pore segment channel 1 JBrowse link 12 41,507,784 41,566,847 RGD:1624291
voltage-gated sodium channel activity involved in AV node cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115
voltage-gated sodium channel activity involved in bundle of His cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115
voltage-gated sodium channel activity involved in cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:1624291
G Scn2b sodium voltage-gated channel beta subunit 2 JBrowse link 8 49,419,003 49,431,110 RGD:1624291
RGD:1600115
G Scn3b sodium voltage-gated channel beta subunit 3 JBrowse link 8 44,136,413 44,159,011 RGD:1624291
RGD:1600115
G Scn4b sodium voltage-gated channel beta subunit 4 JBrowse link 8 49,441,106 49,456,279 RGD:1624291
RGD:1600115
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1600115
RGD:1624291
voltage-gated sodium channel activity involved in Purkinje myocyte action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:1624291
RGD:1600115
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115
voltage-gated sodium channel activity involved in SA node cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18471
    transporter activity 1187
      transmembrane transporter activity 1058
        ion transmembrane transporter activity 866
          ion channel activity 438
            cation channel activity 345
              sodium channel activity 43
                kainate selective glutamate receptor activity 6
                ligand-gated sodium channel activity + 8
                voltage-gated sodium channel activity + 24
Path 2
Term Annotations click to browse term
  molecular_function 18471
    transporter activity 1187
      transmembrane transporter activity 1058
        ion transmembrane transporter activity 866
          cation transmembrane transporter activity 645
            inorganic cation transmembrane transporter activity 596
              metal ion transmembrane transporter activity 444
                sodium ion transmembrane transporter activity 153
                  sodium channel activity 43
                    kainate selective glutamate receptor activity 6
                    ligand-gated sodium channel activity + 8
                    voltage-gated sodium channel activity + 24
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.