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ONTOLOGY REPORT - ANNOTATIONS


Term:nuclear lamina
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Accession:GO:0005652 term browser browse the term
Definition:The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.
Synonyms:xref: NIF_Subcellular:sao1455996588;   Wikipedia:Nuclear_lamina


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nuclear lamina term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cask calcium/calmodulin dependent serine protein kinase JBrowse link X 9,815,652 10,156,155 RGD:1624291
G Hlcs holocarboxylase synthetase JBrowse link 11 34,357,372 34,537,798 RGD:1624291
G Lmnb1 lamin B1 JBrowse link 18 51,785,111 51,822,264 RGD:10044252
G Nup35 nucleoporin 35 JBrowse link 3 67,866,784 67,896,828 RGD:7327145
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:1624291
G Stx1b syntaxin 1B JBrowse link 1 199,251,842 199,270,465 RGD:1624291
lamin filament term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif6 eukaryotic translation initiation factor 6 JBrowse link 3 151,356,867 151,363,201 RGD:1624291
RGD:1600115
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:1624291
RGD:1600115
G Lmnb1 lamin B1 JBrowse link 18 51,785,111 51,822,264 RGD:1624291
RGD:1600115
G Lmnb2 lamin B2 JBrowse link 7 11,657,870 11,676,936 RGD:1624291
G Narf nuclear prelamin A recognition factor JBrowse link 10 110,445,765 110,463,735 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19809
    cellular anatomical entity 19424
      nuclear lamina 10
        lamin filament 5
Path 2
Term Annotations click to browse term
  cellular_component 19809
    cellular anatomical entity 19424
      organelle 12542
        intracellular organelle 12015
          intracellular membrane-bounded organelle 9969
            nucleus 6778
              nuclear lumen 3989
                nuclear periphery 122
                  nuclear lamina 10
                    lamin filament 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.