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ONTOLOGY REPORT - ANNOTATIONS


Term:heterotrimeric G-protein complex
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Accession:GO:0005834 term browser browse the term
Definition:Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
Comment:See also the molecular function term 'G protein-coupled receptor activity ; GO:0004930'.
Synonyms:narrow_synonym: heterotrimeric G-protein GTPase, alpha-subunit;   heterotrimeric G-protein GTPase, beta-subunit;   heterotrimeric G-protein GTPase, gamma-subunit
 related_synonym: heterotrimeric G-protein GTPase activity


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heterotrimeric G-protein complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07033987.1 RGD:13792537
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:13792537
RGD:10448949
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:730287
RGD:13792537
G Gna13 G protein subunit alpha 13 JBrowse link 10 97,647,196 97,680,030 RGD:13792537
G Gna14 G protein subunit alpha 14 JBrowse link 1 235,165,775 235,347,986 RGD:13792537
G Gna15 G protein subunit alpha 15 JBrowse link 7 11,054,249 11,075,152 RGD:13792537
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:625670
RGD:13792537
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:13792537
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:13792537
G Gnal G protein subunit alpha L JBrowse link 18 62,805,406 62,946,133 RGD:13792537
G Gnao1 G protein subunit alpha o1 JBrowse link 19 11,513,201 11,669,578 RGD:13792537
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1299289
RGD:10448949
RGD:13792537
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:1580407
RGD:13792537
RGD:8553387
G Gnat1 G protein subunit alpha transducin 1 JBrowse link 8 116,433,302 116,438,038 RGD:1599009
RGD:13792537
G Gnat2 G protein subunit alpha transducin 2 JBrowse link 2 210,880,754 210,890,765 RGD:13792537
G Gnat3 G protein subunit alpha transducin 3 JBrowse link 4 13,827,764 13,878,126 RGD:1624291
RGD:13792537
G Gnaz G protein subunit alpha z JBrowse link 20 14,593,072 14,644,020 RGD:1578519
RGD:13792537
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:632972
RGD:13792537
RGD:10448949
RGD:1624291
RGD:1599009
G Gnb2 G protein subunit beta 2 JBrowse link 12 22,229,079 22,234,096 RGD:13792537
G Gnb3 G protein subunit beta 3 JBrowse link 4 157,352,558 157,359,237 RGD:13792537
G Gnb4 G protein subunit beta 4 JBrowse link 2 118,978,965 119,007,877 RGD:13792537
G Gnb5 G protein subunit beta 5 JBrowse link 8 82,248,951 82,286,493 RGD:632972
RGD:13792537
G Gng10 G protein subunit gamma 10 JBrowse link 5 76,182,100 76,189,014 RGD:632972
RGD:13792537
G Gng11 G protein subunit gamma 11 JBrowse link 4 28,989,170 28,994,610 RGD:13792537
G Gng12 G protein subunit gamma 12 JBrowse link 4 97,634,925 97,763,478 RGD:13792537
G Gng13 G protein subunit gamma 13 JBrowse link 10 15,088,935 15,090,839 RGD:1624291
G Gng14 G protein subunit gamma 14 JBrowse link 19 26,180,749 26,182,197 RGD:13792537
G Gng2 G protein subunit gamma 2 JBrowse link 15 4,748,242 4,853,555 RGD:632972
RGD:13792537
G Gng3 G protein subunit gamma 3 JBrowse link 1 225,033,921 225,035,687 RGD:13792537
G Gng4 G protein subunit gamma 4 JBrowse link 17 90,266,571 90,316,278 RGD:13792537
G Gng5 G protein subunit gamma 5 JBrowse link 2 252,359,976 252,368,473 RGD:13792537
G Gng7 G protein subunit gamma 7 JBrowse link 7 11,565,740 11,629,519 RGD:61610
RGD:13792537
RGD:1600115
G Gng8 G protein subunit gamma 8 JBrowse link 1 78,818,360 78,822,224 RGD:728592
RGD:13792537
G Gngt1 G protein subunit gamma transducin 1 JBrowse link 4 28,972,339 28,975,419 RGD:1599009
RGD:13792537
G Gngt2 G protein subunit gamma transducin 2 JBrowse link 10 83,654,321 83,658,601 RGD:1624291
RGD:13792537
G LOC100912034 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like JBrowse link 4 31,387,262 31,392,791 RGD:13792537
G LOC108349548 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 JBrowse link 1 78,545,963 78,546,461 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19949
    intracellular 13934
      extrinsic component of cytoplasmic side of plasma membrane 103
        heterotrimeric G-protein complex 37
Path 2
Term Annotations click to browse term
  cellular_component 19949
    cellular anatomical entity 19598
      membrane 9984
        side of membrane 728
          cytoplasmic side of membrane 209
            cytoplasmic side of plasma membrane 170
              extrinsic component of cytoplasmic side of plasma membrane 103
                heterotrimeric G-protein complex 37
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.