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ONTOLOGY REPORT - ANNOTATIONS


Term:nuclear cap binding complex
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Accession:GO:0005846 term browser browse the term
Definition:A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
Comment:Note that this complex can be found in the cytoplasm as well as the nucleus.
Synonyms:narrow_synonym: NCBP-NIP1 complex;   mRNA cap binding complex;   snRNA cap binding complex
 related_synonym: CBC


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nuclear cap binding complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ncbp1 nuclear cap binding protein subunit 1 JBrowse link 5 61,734,118 61,767,098 RGD:9684949
RGD:13792537
G Ncbp2 nuclear cap binding protein subunit 2 JBrowse link 11 72,071,838 72,103,087 RGD:9684949
RGD:13792537
G Snupn snurportin 1 JBrowse link 8 61,614,798 61,654,809 RGD:1331354

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  cellular_component 19843
    intracellular 13807
      nuclear cap binding complex 3
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  cellular_component 19843
    protein-containing complex 5779
      RNA cap binding complex 11
        nuclear cap binding complex 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.