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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin receptor complex
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Accession:GO:0005899 term browser browse the term
Definition:A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.


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insulin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO (PMID:15069075)
nucleic acid dot/slot blot assay��(MMO:0000646)
(PMID:1898103)
BHF-UCL
RGD
UniProt
PMID:1280238, PMID:1898103, PMID:15069075 RGD:15036814 NCBI chrNW_004955563:1,867,400...2,011,845 JBrowse link
G Irs1 insulin receptor substrate 1 ISO PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chrNW_004955453:7,685,715...7,742,262 JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISO RGD PMID:14525909 RGD:11038810 NCBI chrNW_004955507:1,622,567...1,849,047 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 11994
    protein-containing complex 3809
      receptor complex 294
        plasma membrane signaling receptor complex 156
          insulin receptor complex 3
Path 2
Term Annotations click to browse term
  cellular_component 11994
    cellular anatomical entity 11905
      cell periphery 3293
        plasma membrane 3174
          plasma membrane protein complex 402
            plasma membrane signaling receptor complex 156
              insulin receptor complex 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.