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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin receptor complex
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Accession:GO:0005899 term browser browse the term
Definition:A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.


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insulin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IGF1R insulin like growth factor 1 receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387
JBrowse link
G INSR insulin receptor IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr20:52,017,261...52,136,061
Ensembl chr20:52,021,887...52,136,046
JBrowse link
G INSRR insulin receptor related receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:41,161,036...41,176,739
Ensembl chr 7:41,161,333...41,175,940
JBrowse link
G IRS1 insulin receptor substrate 1 ISO PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr25:39,624,554...39,687,991 JBrowse link
G SORBS1 sorbin and SH3 domain containing 1 ISO RGD PMID:14525909 RGD:11038810 NCBI chr28:8,834,530...9,063,739
Ensembl chr28:8,837,338...9,063,777
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16513
    protein-containing complex 5136
      receptor complex 394
        plasma membrane signaling receptor complex 181
          insulin receptor complex 5
Path 2
Term Annotations click to browse term
  cellular_component 16513
    cellular anatomical entity 16417
      cell periphery 4809
        plasma membrane 4665
          plasma membrane protein complex 538
            plasma membrane signaling receptor complex 181
              insulin receptor complex 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.