Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:insulin receptor complex
go back to main search page
Accession:GO:0005899 term browser browse the term
Definition:A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.


show annotations for term's descendants           Sort by:
 
insulin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IGF1R insulin like growth factor 1 receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G INSR insulin receptor IMP
IDA
IBA
(PMID:15069075)
(PMID:1898103)
(PMID:21873635)
BHF-UCL
UniProt
GO_Central
PMID:1898103, PMID:15069075, PMID:21873635 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G INSRR insulin receptor related receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:156,840,063...156,859,117
Ensembl chr 1:156,840,063...156,859,117
JBrowse link
G IRS1 insulin receptor substrate 1 ISS BHF-UCL GO_REF:0000024 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,317...226,799,759
JBrowse link
G SORBS1 sorbin and SH3 domain containing 1 ISO RGD PMID:14525909 RGD:11038810 NCBI chr10:95,311,773...95,561,439
Ensembl chr10:95,311,771...95,561,414
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19299
    protein-containing complex 5869
      receptor complex 543
        plasma membrane signaling receptor complex 322
          insulin receptor complex 5
Path 2
Term Annotations click to browse term
  cellular_component 19299
    cellular anatomical entity 19094
      cell periphery 6057
        plasma membrane 5923
          plasma membrane protein complex 726
            plasma membrane signaling receptor complex 322
              insulin receptor complex 5
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.