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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin receptor complex
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Accession:GO:0005899 term browser browse the term
Definition:A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.


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insulin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1r insulin-like growth factor I receptor IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Insr insulin receptor ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Insrr insulin receptor-related receptor IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:87,796,908...87,816,101
Ensembl chr 3:87,796,951...87,816,101
JBrowse link
G Irs1 insulin receptor substrate 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr19:40,292,040...40,513,955
Ensembl chr19:40,294,753...40,513,779
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 23188
    protein-containing complex 5475
      receptor complex 412
        plasma membrane signaling receptor complex 188
          insulin receptor complex 5
Path 2
Term Annotations click to browse term
  cellular_component 23188
    cellular anatomical entity 19110
      cell periphery 5458
        plasma membrane 5324
          plasma membrane protein complex 563
            plasma membrane signaling receptor complex 188
              insulin receptor complex 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.