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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin receptor complex
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Accession:GO:0005899 term browser browse the term
Definition:A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.


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insulin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1r insulin-like growth factor 1 receptor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Insr insulin receptor IEA
ISO
IEP
IBA
GO_REF:0000107
(PMID:15069075), (PMID:1898103)
nucleic acid dot/slot blot assay��(MMO:0000646)
PMID:21873635
Ensembl
RGD
PMID:1898103, PMID:15069075, PMID:1280238, PMID:21873635 GO_REF:0000107, RGD:15036814, RGD:13792537 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Insrr insulin receptor-related receptor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:187,161,817...187,181,400
Ensembl chr 2:187,162,017...187,181,395
JBrowse link
G Irs1 insulin receptor substrate 1 IMP PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 IDA RGD PMID:14525909 RGD:11038810 NCBI chr 1:259,373,921...259,502,108
Ensembl chr 1:259,376,933...259,484,569
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      receptor complex 413
        plasma membrane signaling receptor complex 187
          insulin receptor complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      cell periphery 6462
        plasma membrane 6307
          plasma membrane protein complex 567
            plasma membrane signaling receptor complex 187
              insulin receptor complex 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.