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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin receptor complex
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Accession:GO:0005899 term browser browse the term
Definition:A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.


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insulin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO (PMID:1898103)
(PMID:15069075)
nucleic acid dot/slot blot assay��(MMO:0000646)
UniProt
BHF-UCL
RGD
PMID:1280238, PMID:1898103, PMID:15069075 RGD:15036814 NCBI chrNW_004936588:4,345,306...4,453,380 JBrowse link
G Irs1 insulin receptor substrate 1 ISO PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chrNW_004936525:9,064,442...9,125,972 JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISO RGD PMID:14525909 RGD:11038810 NCBI chrNW_004936636:3,834,887...4,066,293 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12068
    protein-containing complex 3849
      receptor complex 290
        plasma membrane signaling receptor complex 153
          insulin receptor complex 3
Path 2
Term Annotations click to browse term
  cellular_component 12068
    cellular anatomical entity 11978
      cell periphery 3316
        plasma membrane 3192
          plasma membrane protein complex 405
            plasma membrane signaling receptor complex 153
              insulin receptor complex 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.