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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO (MGI:84168|PMID:7542745) RGD
MGI
PMID:7542745, PMID:12882977 MGI:84168, RGD:4144086 NCBI chrNW_004955420:8,355,415...8,427,024
Ensembl chrNW_004955420:8,356,353...8,427,024
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO RGD PMID:12882977 RGD:4144086 NCBI chrNW_004955501:251,829...381,255
Ensembl chrNW_004955501:259,645...379,909
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:12882977 RGD:4144086 NCBI chrNW_004955410:11,402,476...11,433,335
Ensembl chrNW_004955410:11,402,520...11,437,422
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO RGD PMID:12882977, PMID:20236230 RGD:4107732, RGD:4144086 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820
JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 ISO RGD PMID:12882977 RGD:4144086 NCBI chrNW_004955467:8,025,231...8,091,406
Ensembl chrNW_004955467:8,065,857...8,091,486
JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO (PMID:22402981) UniProtKB PMID:22402981 NCBI chrNW_004955420:8,355,415...8,427,024
Ensembl chrNW_004955420:8,356,353...8,427,024
JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO (PMID:12507995) UniProtKB PMID:12507995 NCBI chrNW_004955410:11,402,476...11,433,335
Ensembl chrNW_004955410:11,402,520...11,437,422
JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 ISO (PMID:12507995) UniProt PMID:12507995 NCBI chrNW_004955467:8,025,231...8,091,406
Ensembl chrNW_004955467:8,065,857...8,091,486
JBrowse link
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 6 ISO (MGI:3574247|PMID:15797027) UniProt PMID:15797027 MGI:3574247 NCBI chrNW_004955467:8,104,242...8,157,637
Ensembl chrNW_004955467:8,104,906...8,157,144
JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chrNW_004955466:13,898,311...13,972,506
Ensembl chrNW_004955466:13,898,298...13,972,506
JBrowse link
G Becn1 beclin 1 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chrNW_004955451:16,616,595...16,625,731 JBrowse link
G Nrbf2 nuclear receptor binding factor 2 colocalizes_with ISO (PMID:24785657)
(MGI:5634877|PMID:24849286)
UniProtKB
UniProt
PMID:24785657, PMID:24849286 MGI:5634877 NCBI chrNW_004955425:16,330,115...16,336,798
Ensembl chrNW_004955425:16,330,114...16,340,621
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chrNW_004955402:28,081,150...28,195,305
Ensembl chrNW_004955402:28,081,098...28,196,252
JBrowse link
G Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chrNW_004955501:7,604,934...7,681,947
Ensembl chrNW_004955501:7,604,501...7,681,947
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12030
    cellular anatomical entity 11885
      extrinsic component of membrane 215
        phosphatidylinositol 3-kinase complex 11
          phosphatidylinositol 3-kinase complex, class I + 4
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 5
Path 2
Term Annotations click to browse term
  cellular_component 12030
    protein-containing complex 3822
      catalytic complex 1055
        transferase complex 591
          transferase complex, transferring phosphorus-containing groups 187
            phosphatidylinositol 3-kinase complex 11
              phosphatidylinositol 3-kinase complex, class I + 4
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.