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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CISH cytokine inducible SH2 containing protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:38,762,239...38,767,701
Ensembl chr20:38,762,378...38,766,620
JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr21:39,693,211...39,868,603
Ensembl chr21:39,695,520...39,784,639
JBrowse link
G PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr38:974,248...1,016,226
Ensembl chr38:975,749...1,027,679
JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr27:28,446,629...28,818,198
Ensembl chr27:28,424,899...28,796,902
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr23:34,832,661...34,955,410
Ensembl chr23:34,836,540...34,993,939
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:62,884,596...62,936,882
Ensembl chr 5:62,909,009...62,935,971
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970
JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:44,826,037...44,838,449
Ensembl chr20:44,826,339...44,836,558
JBrowse link
G PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:14,222,059...14,357,200 JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:33,538,354...33,604,984
Ensembl chr 5:33,532,708...33,604,984
JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:33,472,240...33,528,369
Ensembl chr 5:33,472,771...33,528,400
JBrowse link
G SLA2 Src like adaptor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr24:25,396,187...25,426,789
Ensembl chr24:25,396,900...25,422,467
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:33,761,434...33,788,973
Ensembl chr15:33,785,545...33,877,869
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:2,859,267...2,859,944 JBrowse link
G SOCS4 suppressor of cytokine signaling 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:30,892,663...30,898,896 JBrowse link
G SOCS5 suppressor of cytokine signaling 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:48,916,446...48,977,183
Ensembl chr10:48,972,842...48,974,452
JBrowse link
G SOCS6 suppressor of cytokine signaling 6 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:8,078,500...8,117,651
Ensembl chr 1:8,082,389...8,083,996
JBrowse link
G SOCS7 suppressor of cytokine signaling 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:23,775,349...23,809,325
Ensembl chr 9:23,776,827...23,803,994
JBrowse link
PAS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VAC14 VAC14 component of PIKFYVE complex IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:76,635,931...76,737,414
Ensembl chr 5:76,636,355...76,737,353
JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IEA InterPro GO_REF:0000002 NCBI chr 5:33,538,354...33,604,984
Ensembl chr 5:33,532,708...33,604,984
JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 IEA Ensembl GO_REF:0000107 NCBI chr 5:33,472,240...33,528,369
Ensembl chr 5:33,472,771...33,528,400
JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG14 autophagy related 14 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:31,199,097...31,234,200
Ensembl chr 8:31,201,709...31,234,217
JBrowse link
G BECN1 beclin 1 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chr 9:20,204,203...20,215,081
Ensembl chr 9:20,204,220...20,214,236
JBrowse link
G NRBF2 nuclear receptor binding factor 2 colocalizes_with IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:14,958,142...14,991,146
Ensembl chr 4:14,958,226...14,990,325
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chr 7:48,663,381...48,800,350
Ensembl chr 7:48,663,381...48,800,437
JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chr23:27,902,500...27,973,609
Ensembl chr23:27,902,840...27,971,892
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN2 beclin 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:33,318,124...33,356,388
Ensembl chr 7:33,317,730...33,350,325
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:48,663,381...48,800,350
Ensembl chr 7:48,663,381...48,800,437
JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr23:27,902,500...27,973,609
Ensembl chr23:27,902,840...27,971,892
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN2 beclin 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:33,318,124...33,356,388
Ensembl chr 7:33,317,730...33,350,325
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:48,663,381...48,800,350
Ensembl chr 7:48,663,381...48,800,437
JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr23:27,902,500...27,973,609
Ensembl chr23:27,902,840...27,971,892
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16531
    cellular anatomical entity 16390
      extrinsic component of membrane 320
        phosphatidylinositol 3-kinase complex 28
          phosphatidylinositol 3-kinase complex, class I + 4
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 7
Path 2
Term Annotations click to browse term
  cellular_component 16531
    protein-containing complex 5149
      catalytic complex 1363
        transferase complex 767
          transferase complex, transferring phosphorus-containing groups 240
            phosphatidylinositol 3-kinase complex 28
              phosphatidylinositol 3-kinase complex, class I + 4
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.