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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CISH cytokine inducible SH2 containing protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:50,606,454...50,611,774
Ensembl chr 3:50,606,489...50,611,774
Ensembl chr 3:50,606,489...50,611,774
JBrowse link
G P3R3URF PIK3R3 upstream reading frame IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:46,175,486...46,176,488
Ensembl chr 1:46,175,486...46,176,478
Ensembl chr 1:46,175,486...46,176,478
JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:17,086,575...17,207,986
Ensembl chr11:17,077,730...17,207,983
JBrowse link
G PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:204,422,633...204,494,815
Ensembl chr 1:204,422,628...204,494,724
JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:18,242,946...18,716,861
Ensembl chr12:18,242,961...18,648,416
Ensembl chr12:18,242,961...18,648,416
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISS
IBA
(PMID:21873635) BHF-UCL
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta NAS
IBA
(PMID:9113989), (PMID:9235916)
(PMID:21873635)
UniProtKB
GO_Central
PMID:9113989, PMID:9235916, PMID:21873635 NCBI chr 1:9,629,889...9,729,114
Ensembl chr 1:9,651,731...9,729,114
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISS
IBA
(PMID:21873635) BHF-UCL
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:18,153,163...18,170,532
Ensembl chr19:18,153,163...18,170,532
JBrowse link
G PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:46,040,140...46,174,901
Ensembl chr 1:46,040,140...46,133,036
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712
JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:8,802,722...8,870,003
Ensembl chr17:8,802,722...8,867,677
Ensembl chr17:8,802,722...8,867,677
JBrowse link
G SLA2 Src like adaptor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:36,612,318...36,646,207
Ensembl chr20:36,612,318...36,646,196
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,408...11,256,204
Ensembl chr16:11,254,408...11,256,204
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:93,569,849...93,626,236
Ensembl chr12:93,569,814...93,583,487
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOCS4 suppressor of cytokine signaling 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:55,027,131...55,049,489
Ensembl chr14:55,027,230...55,049,489
JBrowse link
G SOCS5 suppressor of cytokine signaling 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:46,698,937...46,763,129
Ensembl chr 2:46,698,952...46,780,245
JBrowse link
G SOCS6 suppressor of cytokine signaling 6 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr18:70,289,045...70,330,199
Ensembl chr18:70,289,045...70,330,199
JBrowse link
G SOCS7 suppressor of cytokine signaling 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:38,351,844...38,405,593
Ensembl chr17:38,351,844...38,405,593
JBrowse link
PAS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VAC14 VAC14 component of PIKFYVE complex IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr16:70,687,439...70,801,158
Ensembl chr16:70,687,439...70,801,160
JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IDA
IBA
(PMID:22402981)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:22402981 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISS UniProtKB GO_REF:0000024 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IDA
IBA
(PMID:12507995)
(PMID:21873635)
UniProtKB
GO_Central
PMID:12507995, PMID:21873635 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IEA
ISS
InterPro
UniProtKB
GO_REF:0000002, GO_REF:0000024 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712
JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 ISS
IEA
UniProtKB
InterPro
GO_REF:0000002, GO_REF:0000024 NCBI chr17:8,802,722...8,870,003
Ensembl chr17:8,802,722...8,867,677
Ensembl chr17:8,802,722...8,867,677
JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG14 autophagy related 14 ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr14:55,366,391...55,411,830
Ensembl chr14:55,366,391...55,411,830
Ensembl chr14:55,366,391...55,411,830
JBrowse link
G BECN1 beclin 1 ISS UniProtKB GO_REF:0000024 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G NRBF2 nuclear receptor binding factor 2 colocalizes_with IDA
IBA
(PMID:24785657)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:24785657 NCBI chr10:63,133,325...63,155,029
Ensembl chr10:63,133,247...63,155,031
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 ISS UniProtKB GO_REF:0000024 NCBI chr18:41,955,226...42,087,830
Ensembl chr18:41,955,234...42,087,830
JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 ISS UniProtKB GO_REF:0000024 NCBI chr 3:130,678,934...130,746,829
Ensembl chr 3:130,678,934...130,746,829
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BECN2 beclin 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:241,957,767...241,959,062
Ensembl chr 1:241,957,767...241,959,062
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:41,955,226...42,087,830
Ensembl chr18:41,955,234...42,087,830
JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:130,678,934...130,746,829
Ensembl chr 3:130,678,934...130,746,829
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BECN2 beclin 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:241,957,767...241,959,062
Ensembl chr 1:241,957,767...241,959,062
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:41,955,226...42,087,830
Ensembl chr18:41,955,234...42,087,830
JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:130,678,934...130,746,829
Ensembl chr 3:130,678,934...130,746,829
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19337
    cellular anatomical entity 19101
      extrinsic component of membrane 351
        phosphatidylinositol 3-kinase complex 29
          phosphatidylinositol 3-kinase complex, class I + 5
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 7
Path 2
Term Annotations click to browse term
  cellular_component 19337
    protein-containing complex 5896
      catalytic complex 1452
        transferase complex 820
          transferase complex, transferring phosphorus-containing groups 269
            phosphatidylinositol 3-kinase complex 29
              phosphatidylinositol 3-kinase complex, class I + 5
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.