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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700042G07Rik RIKEN cDNA 1700042G07 gene IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 4:116,173,372...116,174,297
Ensembl chr 4:116,173,372...116,174,290
JBrowse link
G Cish cytokine inducible SH2-containing protein IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 9:107,296,659...107,302,784
Ensembl chr 9:107,296,026...107,302,784
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:116,337,265...116,443,465
Ensembl chr 7:116,337,265...116,443,449
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 1:133,045,672...133,108,691
Ensembl chr 1:133,045,667...133,108,687
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 6:139,614,072...139,969,284
Ensembl chr 6:139,587,221...139,969,284
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO
IBA
IPI
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:84168|PMID:7542745)
RGD
GO_Central
MGI
PMID:7542745, PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:6201960, MGI:MGI:84168 NCBI chr 3:32,397,065...32,466,112
Ensembl chr 3:32,397,671...32,468,486
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO
IBA
(MGI:MGI:6201960|PMID:21873635) RGD
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:6201960 NCBI chr 9:99,038,402...99,140,235
Ensembl chr 9:99,036,654...99,140,621
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 4:149,649,168...149,702,566
Ensembl chr 4:149,649,168...149,702,571
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO
IBA
(MGI:MGI:6201960|PMID:21873635) RGD
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:6201960 NCBI chr12:32,173,397...32,208,677
Ensembl chr12:32,173,473...32,208,659
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 TAS
IBA
ISO
(MGI:MGI:1329776|PMID:9988280)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
RGD
PMID:9988280, PMID:21873635 GO_REF:0000096, MGI:MGI:1329776, MGI:MGI:4417868, MGI:MGI:6201960 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 8:70,768,176...70,776,712
Ensembl chr 8:70,768,176...70,776,713
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IPI
IBA
(MGI:MGI:84168|PMID:7542745)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:7542745, PMID:21873635 MGI:MGI:6201960, MGI:MGI:84168 NCBI chr 4:116,221,400...116,303,056
Ensembl chr 4:116,221,618...116,303,056
Ensembl chr 4:116,221,618...116,303,056
JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) RGD
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:6201960 NCBI chr11:68,432,125...68,497,849
Ensembl chr11:68,432,121...68,497,849
JBrowse link
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr11:68,503,019...68,552,698
Ensembl chr11:68,503,019...68,552,698
JBrowse link
G Sla2 Src-like-adaptor 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 2:156,874,151...156,887,250
Ensembl chr 2:156,872,457...156,887,192
JBrowse link
G Socs1 suppressor of cytokine signaling 1 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr16:10,783,808...10,785,536
Ensembl chr16:10,782,240...10,785,536
JBrowse link
G Socs2 suppressor of cytokine signaling 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr10:95,383,903...95,417,321
Ensembl chr10:95,385,362...95,417,180
JBrowse link
G Socs3 suppressor of cytokine signaling 3 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Socs4 suppressor of cytokine signaling 4 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr14:47,276,920...47,296,102
Ensembl chr14:47,276,931...47,296,102
JBrowse link
G Socs5 suppressor of cytokine signaling 5 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr17:87,107,278...87,137,647
Ensembl chr17:87,107,679...87,137,839
JBrowse link
G Socs6 suppressor of cytokine signaling 6 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr18:88,865,169...88,894,364
Ensembl chr18:88,665,224...88,927,481
JBrowse link
G Socs7 suppressor of cytokine signaling 7 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr11:97,362,292...97,398,542
Ensembl chr11:97,362,435...97,398,542
JBrowse link
PAS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vac14 Vac14 homolog (S. cerevisiae) IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 8:110,618,529...110,720,398
Ensembl chr 8:110,618,585...110,720,398
JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 3:32,397,065...32,466,112
Ensembl chr 3:32,397,671...32,468,486
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr12:32,173,397...32,208,677
Ensembl chr12:32,173,473...32,208,659
JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:32,397,065...32,466,112
Ensembl chr 3:32,397,671...32,468,486
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr12:32,173,397...32,208,677
Ensembl chr12:32,173,473...32,208,659
JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 IEA UniProtKB GO_REF:0000002, MGI:MGI:2152098 NCBI chr11:68,432,125...68,497,849
Ensembl chr11:68,432,121...68,497,849
JBrowse link
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 IDA (MGI:MGI:3574247|PMID:15797027) UniProtKB PMID:15797027 MGI:MGI:3574247 NCBI chr11:68,503,019...68,552,698
Ensembl chr11:68,503,019...68,552,698
JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 IDA
IBA
(MGI:MGI:5619439|PMID:23332761)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:23332761 MGI:MGI:5619439, MGI:MGI:6201960 NCBI chr14:47,540,893...47,568,434
Ensembl chr14:47,540,893...47,570,649
JBrowse link
G Becn1 beclin 1, autophagy related IDA (MGI:MGI:5619439|PMID:23332761) UniProtKB PMID:23332761 MGI:MGI:5619439 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 colocalizes_with IDA
IBA
ISO
(MGI:MGI:5634877|PMID:24849286)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
GO_Central
MGI
PMID:21873635, PMID:24849286 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:5634877, MGI:MGI:6201960 NCBI chr10:67,266,689...67,285,343
Ensembl chr10:67,266,689...67,285,305
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 IDA (MGI:MGI:5619439|PMID:23332761) UniProtKB PMID:23332761 MGI:MGI:5619439 NCBI chr18:30,265,615...30,348,126
Ensembl chr18:30,272,747...30,348,126
JBrowse link
G Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 IDA (MGI:MGI:5619439|PMID:23332761) UniProtKB PMID:23332761 MGI:MGI:5619439 NCBI chr 9:105,642,995...105,687,655
Ensembl chr 9:105,642,978...105,687,657
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1, autophagy related IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Becn2 beclin 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 1:175,920,329...175,922,225
Ensembl chr 1:175,920,329...175,922,225
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr18:30,265,615...30,348,126
Ensembl chr18:30,272,747...30,348,126
JBrowse link
G Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 9:105,642,995...105,687,655
Ensembl chr 9:105,642,978...105,687,657
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1, autophagy related IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Becn2 beclin 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 1:175,920,329...175,922,225
Ensembl chr 1:175,920,329...175,922,225
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr18:30,265,615...30,348,126
Ensembl chr18:30,272,747...30,348,126
JBrowse link
G Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 9:105,642,995...105,687,655
Ensembl chr 9:105,642,978...105,687,657
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 23185
    cellular anatomical entity 19098
      extrinsic component of membrane 328
        phosphatidylinositol 3-kinase complex 29
          phosphatidylinositol 3-kinase complex, class I + 4
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 7
Path 2
Term Annotations click to browse term
  cellular_component 23185
    protein-containing complex 5493
      catalytic complex 1388
        transferase complex 770
          transferase complex, transferring phosphorus-containing groups 244
            phosphatidylinositol 3-kinase complex 29
              phosphatidylinositol 3-kinase complex, class I + 4
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.