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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CISH cytokine inducible SH2 containing protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:33,086,280...33,090,540
Ensembl chr13:33,084,873...33,090,615
JBrowse link
G LOC100511937 phosphatidylinositol 3-kinase regulatory subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:165,268,260...165,402,668 JBrowse link
G NDRG3 NDRG family member 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:39,905,957...39,987,754 JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:41,829,969...42,024,062
Ensembl chr 2:41,829,916...42,024,362
JBrowse link
G PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:65,073,728...65,154,861
Ensembl chr 9:65,073,738...65,154,538
JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:54,474,623...54,849,520
Ensembl chr 5:54,474,624...54,849,512
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,277,232
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:79,427,033...79,610,840
Ensembl chr13:79,425,812...79,610,840
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:70,026,254...70,086,950
Ensembl chr 6:70,026,373...70,099,244
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:59,637,363...59,652,075 JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:53,979,206...54,046,927
Ensembl chr12:53,979,215...54,055,377
JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:53,910,999...53,971,088
Ensembl chr12:53,906,506...53,971,015
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,969
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:89,581,081...89,587,424
Ensembl chr 5:89,242,169...89,586,239
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012
JBrowse link
G SOCS4 suppressor of cytokine signaling 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:184,379,017...184,398,902
Ensembl chr 1:184,379,086...184,398,902
JBrowse link
G SOCS5 suppressor of cytokine signaling 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:93,777,402...93,925,859
Ensembl chr 3:93,783,964...93,925,865
JBrowse link
G SOCS6 suppressor of cytokine signaling 6 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:152,593,647...152,636,645
Ensembl chr 1:152,593,649...152,636,651
JBrowse link
G SOCS7 suppressor of cytokine signaling 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:23,687,115...23,723,427
Ensembl chr12:23,688,699...23,723,377
JBrowse link
PAS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VAC14 VAC14 component of PIKFYVE complex IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:13,683,800...13,791,246
Ensembl chr 6:13,683,799...13,791,241
JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,277,232
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,277,232
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IDA
IEA
(PMID:12507995) UniProt
InterPro
PMID:12507995 GO_REF:0000002 NCBI chr12:53,979,206...54,046,927
Ensembl chr12:53,979,215...54,055,377
JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr12:53,910,999...53,971,088
Ensembl chr12:53,906,506...53,971,015
JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG14 autophagy related 14 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:184,701,020...184,743,752
Ensembl chr 1:184,686,142...184,743,753
JBrowse link
G BECN1 beclin 1 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G NRBF2 nuclear receptor binding factor 2 colocalizes_with IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr14:66,590,307...66,629,573
Ensembl chr14:66,590,372...66,631,386
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 6:125,890,598...126,038,753
Ensembl chr 6:125,890,708...126,043,161
JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 IEA Ensembl GO_REF:0000107 NCBI chr13:1,730,988...1,815,555
Ensembl chr13:1,731,017...1,815,556
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G BECN2 beclin 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:15,388,712...15,390,250
Ensembl chr10:15,388,605...15,390,226
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:125,890,598...126,038,753
Ensembl chr 6:125,890,708...126,043,161
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G BECN2 beclin 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:15,388,712...15,390,250
Ensembl chr10:15,388,605...15,390,226
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:125,890,598...126,038,753
Ensembl chr 6:125,890,708...126,043,161
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16944
    cellular anatomical entity 16805
      extrinsic component of membrane 320
        phosphatidylinositol 3-kinase complex 28
          phosphatidylinositol 3-kinase complex, class I + 4
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 7
Path 2
Term Annotations click to browse term
  cellular_component 16944
    protein-containing complex 4975
      catalytic complex 1330
        transferase complex 744
          transferase complex, transferring phosphorus-containing groups 243
            phosphatidylinositol 3-kinase complex 28
              phosphatidylinositol 3-kinase complex, class I + 4
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.