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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cish cytokine inducible SH2-containing protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G LOC100910021 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:106,862,181...106,871,375
Ensembl chr 8:106,863,494...106,870,994
JBrowse link
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:23,243,126...23,254,011
Ensembl chr  X:23,243,470...23,246,719
JBrowse link
G P3r3urf PIK3R3 upstream reading frame IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:135,029,480...135,046,282
Ensembl chr 5:135,029,955...135,030,801
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:49,848,939...49,909,404
Ensembl chr13:49,850,189...49,911,202
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:173,732,196...174,102,502
Ensembl chr 4:173,732,248...174,102,496
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IDA
ISO
IBA
PR:Q64143 (MGI:84168|PMID:7542745)
PMID:21873635
RGD PMID:7542745, PMID:12882977, PMID:21873635 MGI:84168, RGD:4144086, RGD:13792537 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:12882977, PMID:21873635 RGD:4144086, RGD:13792537 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:12882977, PMID:21873635 RGD:4144086, RGD:13792537 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 TAS
IBA
IDA
PMID:21873635 RGD
GO_Central
PMID:8621382, PMID:21873635, PMID:20236230, PMID:12882977 RGD:68289, RGD:13792537, RGD:4107732, RGD:4144086 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IBA
ISO
PMID:21873635
PR:P42337 (MGI:84168|PMID:7542745)
RGD PMID:7542745, PMID:21873635 MGI:84168, RGD:13792537 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:12882977, PMID:21873635 RGD:4144086, RGD:13792537 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:55,085,269...55,135,069
Ensembl chr10:55,085,259...55,135,092
JBrowse link
G Sla2 Src-like-adaptor 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:152,942,838...153,004,047
Ensembl chr 3:152,944,452...153,001,309
JBrowse link
G Socs1 suppressor of cytokine signaling 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs2 suppressor of cytokine signaling 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Socs3 suppressor of cytokine signaling 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Socs4 suppressor of cytokine signaling 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:24,056,383...24,070,868
Ensembl chr15:24,056,383...24,070,857
JBrowse link
G Socs5 suppressor of cytokine signaling 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:10,671,311...10,705,610
Ensembl chr 6:10,674,371...10,704,977
JBrowse link
G Socs6 suppressor of cytokine signaling 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:85,962,729...85,981,125
Ensembl chr18:85,962,729...85,980,833
JBrowse link
G Socs7 suppressor of cytokine signaling 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:85,301,797...85,337,971
Ensembl chr10:85,301,875...85,330,397
JBrowse link
PAS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vac14 VAC14 component of PIKFYVE complex IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:40,927,007...41,029,206
Ensembl chr19:40,927,007...41,029,206
JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:23,243,126...23,254,011
Ensembl chr  X:23,243,470...23,246,719
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IBA
(PMID:22402981)
PMID:21873635
RGD PMID:22402981, PMID:21873635 RGD:13792537 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:23,243,126...23,254,011
Ensembl chr  X:23,243,470...23,246,719
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO
IBA
(PMID:12507995)
PMID:21873635
RGD PMID:12507995, PMID:21873635 RGD:13792537 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA
ISO
GO_REF:0000002
(PMID:12507995)
InterPro
RGD
PMID:12507995 GO_REF:0000002 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 ISO (MGI:3574247|PMID:15797027) RGD PMID:15797027 MGI:3574247 NCBI chr10:55,085,269...55,135,069
Ensembl chr10:55,085,259...55,135,092
JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 ISS
ISO
IBA
GO_REF:0000024
(MGI:5619439|PMID:23332761)
PMID:21873635
UniProt
RGD
PMID:23332761, PMID:21873635 GO_REF:0000024, MGI:5619439, RGD:13792537 NCBI chr15:24,343,418...24,374,776
Ensembl chr15:24,343,314...24,374,753
JBrowse link
G Becn1 beclin 1 ISS
ISO
GO_REF:0000024
(MGI:5619439|PMID:23332761)
UniProt
RGD
PMID:23332761 GO_REF:0000024, MGI:5619439 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 colocalizes_with IEA
ISO
IBA
GO_REF:0000107
(MGI:5634877|PMID:24849286)
PMID:21873635
(PMID:24785657)
Ensembl
RGD
PMID:24785657, PMID:24849286, PMID:21873635 GO_REF:0000107, MGI:5634877, RGD:13792537 NCBI chr20:22,728,145...22,746,477
Ensembl chr20:22,728,208...22,746,474
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 ISS
ISO
GO_REF:0000024
(MGI:5619439|PMID:23332761)
UniProt
RGD
PMID:23332761 GO_REF:0000024, MGI:5619439 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 ISS
ISO
GO_REF:0000024
(MGI:5619439|PMID:23332761)
UniProt
RGD
PMID:23332761 GO_REF:0000024, MGI:5619439 NCBI chr 8:114,300,248...114,350,686
Ensembl chr 8:114,300,257...114,350,681
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Becn2 beclin 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:93,971,720...93,974,467
Ensembl chr13:93,972,426...93,974,410
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:114,300,248...114,350,686
Ensembl chr 8:114,300,257...114,350,681
JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Becn2 beclin 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:93,971,720...93,974,467
Ensembl chr13:93,972,426...93,974,410
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:114,300,248...114,350,686
Ensembl chr 8:114,300,257...114,350,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      extrinsic component of membrane 337
        phosphatidylinositol 3-kinase complex 31
          phosphatidylinositol 3-kinase complex, class I + 6
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 7
Path 2
Term Annotations click to browse term
  cellular_component 20602
    protein-containing complex 6103
      catalytic complex 1496
        transferase complex 821
          transferase complex, transferring phosphorus-containing groups 266
            phosphatidylinositol 3-kinase complex 31
              phosphatidylinositol 3-kinase complex, class I + 6
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.