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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO (MGI:84168|PMID:7542745) RGD
MGI
PMID:7542745, PMID:12882977 MGI:84168, RGD:4144086 NCBI chrNW_004936566:3,924,013...3,951,052 JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO RGD PMID:12882977 RGD:4144086 NCBI chrNW_004936540:907,118...1,041,814 JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:12882977 RGD:4144086 NCBI chrNW_004936479:17,084,006...17,112,264 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO RGD PMID:12882977, PMID:20236230 RGD:4107732, RGD:4144086 NCBI chrNW_004936480:1,188,408...1,273,210 JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO (MGI:84168|PMID:7542745) MGI PMID:7542745 MGI:84168 NCBI chrNW_004936474:27,095,125...27,171,416 JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 ISO RGD PMID:12882977 RGD:4144086 NCBI chrNW_004936595:2,029,074...2,053,954 JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO (PMID:22402981) UniProtKB PMID:22402981 NCBI chrNW_004936566:3,924,013...3,951,052 JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO (PMID:12507995) UniProtKB PMID:12507995 NCBI chrNW_004936479:17,084,006...17,112,264 JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 ISO (PMID:12507995) UniProt PMID:12507995 NCBI chrNW_004936595:2,029,074...2,053,954 JBrowse link
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 6 ISO (MGI:3574247|PMID:15797027) UniProt PMID:15797027 MGI:3574247 NCBI chrNW_004936595:1,953,372...1,983,765 JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chrNW_004936495:155,709...195,860 JBrowse link
G Becn1 beclin 1 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chrNW_004936490:17,518,100...17,531,126 JBrowse link
G Nrbf2 nuclear receptor binding factor 2 colocalizes_with ISO (PMID:24785657)
(MGI:5634877|PMID:24849286)
UniProtKB
UniProt
PMID:24785657, PMID:24849286 MGI:5634877 NCBI chrNW_004936753:1,653,394...1,671,996 JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chrNW_004936517:4,009,938...4,145,518 JBrowse link
G Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 ISO (MGI:5619439|PMID:23332761) UniProt PMID:23332761 MGI:5619439 NCBI chrNW_004936529:4,162,276...4,232,471 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12106
    cellular anatomical entity 11959
      extrinsic component of membrane 219
        phosphatidylinositol 3-kinase complex 12
          phosphatidylinositol 3-kinase complex, class I + 4
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 5
Path 2
Term Annotations click to browse term
  cellular_component 12106
    protein-containing complex 3865
      catalytic complex 1064
        transferase complex 600
          transferase complex, transferring phosphorus-containing groups 190
            phosphatidylinositol 3-kinase complex 12
              phosphatidylinositol 3-kinase complex, class I + 4
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.