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Term:mitochondrial pyruvate dehydrogenase complex
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Accession:GO:0005967 term browser browse the term
Definition:Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
Comment:Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
Synonyms:broad_synonym: pyruvate dehydrogenase complex (lipoamide)

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mitochondrial pyruvate dehydrogenase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:729480
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 JBrowse link 2 246,736,449 246,737,997 RGD:13792537
G Pdhb pyruvate dehydrogenase E1 subunit beta JBrowse link 15 18,540,826 18,546,855 RGD:13792537
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:1600115
G Pdk2 pyruvate dehydrogenase kinase 2 JBrowse link 10 82,838,270 82,852,758 RGD:1600115

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  cellular_component 19733
    protein-containing complex 5748
      mitochondrial protein complex 289
        mitochondrial pyruvate dehydrogenase complex 5
Path 2
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  cellular_component 19733
    cellular anatomical entity 19350
      organelle 12456
        intracellular organelle 11935
          intracellular membrane-bounded organelle 9923
            mitochondrion 1610
              mitochondrial matrix 318
                mitochondrial pyruvate dehydrogenase complex 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.