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ONTOLOGY REPORT - ANNOTATIONS


Term:acetyl-CoA metabolic process
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Accession:GO:0006084 term browser browse the term
Definition:The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms:exact_synonym: acetyl coenzyme A metabolic process;   acetyl coenzyme A metabolism;   acetyl-CoA metabolism


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acetyl-CoA metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:2317620
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:1600115
RGD:1624291
G Acacb acetyl-CoA carboxylase beta JBrowse link 12 48,127,149 48,238,969 RGD:1624291
G Acly ATP citrate lyase JBrowse link 10 88,392,248 88,442,845 RGD:2317315
G Acot12 acyl-CoA thioesterase 12 JBrowse link 2 20,857,056 20,901,656 RGD:1624291
RGD:1600115
G Cs citrate synthase JBrowse link 7 2,752,680 2,778,963 RGD:2306824
RGD:2306828
RGD:2306825
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:2317315
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:13792537
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 2 200,452,623 200,480,785 RGD:13792537
acetyl-CoA biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acat1 acetyl-CoA acetyltransferase 1 JBrowse link 8 58,166,990 58,195,884 RGD:1624291
G Acly ATP citrate lyase JBrowse link 10 88,392,248 88,442,845 RGD:631761
RGD:13792537
RGD:1600115
RGD:1624291
G Acss1 acyl-CoA synthetase short-chain family member 1 JBrowse link 3 146,420,346 146,470,293 RGD:1624291
G Acss2 acyl-CoA synthetase short-chain family member 2 JBrowse link 3 151,032,925 151,075,856 RGD:1624291
G Mlycd malonyl-CoA decarboxylase JBrowse link 19 52,032,950 52,048,773 RGD:1600790
RGD:13792537
RGD:1624291
RGD:1600115
G Ppcs phosphopantothenoylcysteine synthetase JBrowse link 5 138,466,298 138,470,108 RGD:1624291
acetyl-CoA biosynthetic process from acetate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acss1 acyl-CoA synthetase short-chain family member 1 JBrowse link 3 146,420,346 146,470,293 RGD:1600115
acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dlat dihydrolipoamide S-acetyltransferase JBrowse link 8 55,062,549 55,087,832 RGD:1599112
G Dld dihydrolipoamide dehydrogenase JBrowse link 6 50,597,677 50,618,694 RGD:1599112
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:1599112
RGD:13792537
RGD:1624291
RGD:1600115
G Pdha1l1 pyruvate dehydrogenase (lipoamide) alpha 1-like 1 JBrowse link 16 88,344,440 88,347,335 RGD:1600115
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 JBrowse link 2 246,736,449 246,737,997 RGD:1599112
RGD:13792537
G Pdhb pyruvate dehydrogenase E1 subunit beta JBrowse link 15 18,540,826 18,546,855 RGD:1599112
RGD:13792537
RGD:1624291
RGD:1600115
G Pdhx pyruvate dehydrogenase complex, component X JBrowse link 3 92,910,300 92,933,725 RGD:1600115
G Pdk4 pyruvate dehydrogenase kinase 4 JBrowse link 4 30,546,772 30,556,774 RGD:729541
acetyl-CoA catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acat1 acetyl-CoA acetyltransferase 1 JBrowse link 8 58,166,990 58,195,884 RGD:1624291
G Nudt7 nudix hydrolase 7 JBrowse link 19 46,455,745 46,470,070 RGD:1624291
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mvd mevalonate diphosphate decarboxylase JBrowse link 19 55,258,910 55,268,933 RGD:2316852
RGD:13792537
RGD:1600115
G Mvk mevalonate kinase JBrowse link 12 47,904,266 47,920,457 RGD:2316852
RGD:13792537
RGD:1600115
G Pmvk phosphomevalonate kinase JBrowse link 2 188,784,329 188,793,890 RGD:2316852
RGD:13792537
RGD:1600115
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pipox pipecolic acid and sarcosine oxidase JBrowse link 10 64,951,986 64,964,865 RGD:1624291
RGD:13792537
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aadat aminoadipate aminotransferase JBrowse link 16 32,832,001 32,868,680 RGD:1600115
G Aass aminoadipate-semialdehyde synthase JBrowse link 4 50,152,005 50,208,935 RGD:1600115
G Dlst dihydrolipoamide S-succinyltransferase JBrowse link 6 108,936,534 108,961,322 RGD:1600115
mitochondrial acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpc1 mitochondrial pyruvate carrier 1 JBrowse link 1 53,026,608 53,038,229 RGD:1624291
G Mpc2 mitochondrial pyruvate carrier 2 JBrowse link 13 83,680,527 83,700,491 RGD:1624291
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:1624291
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:1600115
RGD:1624291
G Pdk2 pyruvate dehydrogenase kinase 2 JBrowse link 10 82,838,270 82,852,758 RGD:1600115
RGD:1624291
G Pdk3 pyruvate dehydrogenase kinase 3 JBrowse link X 62,836,131 62,904,114 RGD:1624291
G Pdk4 pyruvate dehydrogenase kinase 4 JBrowse link 4 30,546,772 30,556,774 RGD:1600115
RGD:1624291
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kynu kynureninase JBrowse link 3 28,416,926 28,566,939 RGD:2303721
G Tdo2 tryptophan 2,3-dioxygenase JBrowse link 2 180,897,059 180,914,919 RGD:2303721
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    metabolic process 11555
      organic substance metabolic process 10949
        thioester metabolic process 88
          acyl-CoA metabolic process 88
            acetyl-CoA metabolic process 37
              L-lysine catabolic process to acetyl-CoA + 4
              L-threonine catabolic process to acetyl-CoA 0
              acetyl-CoA biosynthetic process + 19
              acetyl-CoA catabolic process + 2
              butyryl-CoA biosynthetic process from acetyl-CoA + 0
              isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
              tryptophan catabolic process to acetyl-CoA 2
Path 2
Term Annotations click to browse term
  biological_process 19336
    metabolic process 11555
      cellular metabolic process 10567
        cellular aromatic compound metabolic process 5482
          nucleobase-containing compound metabolic process 5256
            nucleobase-containing small molecule metabolic process 575
              nucleoside phosphate metabolic process 496
                nucleotide metabolic process 489
                  purine nucleotide metabolic process 402
                    purine ribonucleotide metabolic process 377
                      acyl-CoA metabolic process 88
                        acetyl-CoA metabolic process 37
                          L-lysine catabolic process to acetyl-CoA + 4
                          L-threonine catabolic process to acetyl-CoA 0
                          acetyl-CoA biosynthetic process + 19
                          acetyl-CoA catabolic process + 2
                          butyryl-CoA biosynthetic process from acetyl-CoA + 0
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway + 3
                          tryptophan catabolic process to acetyl-CoA 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.